STRINGSTRING
TPBG TPBG SOX17 SOX17 PTPRU PTPRU LZTS2 LZTS2 MCC MCC TAX1BP3 TAX1BP3 SHISA6 SHISA6 FGF9 FGF9 TLE5 TLE5 LOC100980541 LOC100980541 NOG NOG WNT11 WNT11 AMER1 AMER1 APC2 APC2 SLC9A3R1 SLC9A3R1 APCDD1 APCDD1 TRABD2B TRABD2B SNAI2 SNAI2 RNF213 RNF213 NKD1 NKD1 FERMT1 FERMT1 CSNK1A1L CSNK1A1L GRB10 GRB10 MDK MDK LIMD1 LIMD1 TSKU TSKU NFATC4 NFATC4 NPHP4 NPHP4 MLLT3 MLLT3 TLE3 TLE3 WNT5A WNT5A ENSPPAP00000008445 ENSPPAP00000008445 EMD EMD STK4 STK4 CTNNBIP1 CTNNBIP1 G3BP1 G3BP1 JADE1 JADE1 CYLD CYLD HMGXB4 HMGXB4 SIAH2 SIAH2 DKKL1 DKKL1 SHISA3 SHISA3 UBAC2 UBAC2 SOX10 SOX10 CTHRC1 CTHRC1 ANKRD6 ANKRD6 TBX18 TBX18 ENSPPAP00000011186 ENSPPAP00000011186 INVS INVS DAB2 DAB2 LOC100981302 LOC100981302 SOX13 SOX13 LRP1 LRP1 TLE6 TLE6 EGR1 EGR1 TCF7L2 TCF7L2 MESP1 MESP1 WIF1 WIF1 BMP2 BMP2 KREMEN1 KREMEN1 FOXO1 FOXO1 NLK NLK NFATC1 NFATC1 HECW1 HECW1 NKX2-5 NKX2-5 AXIN1 AXIN1 CBY1 CBY1 SFRP5 SFRP5 RBX1 RBX1 FRZB FRZB ENSPPAP00000017361 ENSPPAP00000017361 CCDC88C CCDC88C SHISA2 SHISA2 SCYL2 SCYL2 HDAC1 HDAC1 APC APC TMEM64 TMEM64 ENSPPAP00000019393 ENSPPAP00000019393 AMER2 AMER2 SHH SHH DKK4 DKK4 SFRP4 SFRP4 TSC2 TSC2 TMEM170B TMEM170B AXIN2 AXIN2 ISL1 ISL1 DDIT3 DDIT3 SFRP1 SFRP1 DKK1 DKK1 RNF43 RNF43 SOSTDC1 SOSTDC1 NKD2 NKD2 DACT1 DACT1 ENSPPAP00000022866 ENSPPAP00000022866 LOC100975570 LOC100975570 PRKN PRKN BICC1 BICC1 FZD6 FZD6 CTNNB1 CTNNB1 RACK1 RACK1 DRAXIN DRAXIN MAD2L2 MAD2L2 TMEM88 TMEM88 VGLL4 VGLL4 ENSPPAP00000025550 ENSPPAP00000025550 TMEM131L TMEM131L PTPRO PTPRO APCDD1L APCDD1L LATS1 LATS1 FRMD8 FRMD8 NOTUM NOTUM RBMS3 RBMS3 GSK3A GSK3A CAV1 CAV1 TLE1 TLE1 PFDN5 PFDN5 CITED1 CITED1 CDH2 CDH2 NPPA NPPA ENSPPAP00000029665 ENSPPAP00000029665 MDFI MDFI WWOX WWOX DKK2 DKK2 RUVBL2 RUVBL2 TLE2 TLE2 SOST SOST WWTR1 WWTR1 DAB2IP DAB2IP PPP2R3A PPP2R3A ENSPPAP00000033311 ENSPPAP00000033311 NOTCH1 NOTCH1 TNN TNN TRABD2A TRABD2A FZD4 FZD4 ENSPPAP00000034340 ENSPPAP00000034340 CHD8 CHD8 IGFBP1 IGFBP1 TLE4 TLE4 NXN NXN GSC GSC STK3 STK3 GSK3B GSK3B LATS2 LATS2 SOX2 SOX2 DACT3 DACT3 AMFR AMFR CSNK1A1 CSNK1A1 TLE7 TLE7 IFT80 IFT80 DKK3 DKK3 MAPK14 MAPK14 FUZ FUZ CTNND1 CTNND1 PRICKLE1 PRICKLE1 SOX30 SOX30 GLI3 GLI3 OTUD5 OTUD5 GLI1 GLI1 LMBR1L LMBR1L LRP4 LRP4 C12orf43 C12orf43 STK11 STK11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TPBGTrophoblast glycoprotein. (419 aa)
SOX17SRY-box transcription factor 17. (428 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1296 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
MCCMCC regulator of WNT signaling pathway. (910 aa)
TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
SHISA6Shisa family member 6. (461 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TLE5TLE family member 5, transcriptional modulator. (264 aa)
LOC100980541Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (507 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
AMER1APC membrane recruitment protein 1. (1136 aa)
APC2Uncharacterized protein. (1779 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
APCDD1APC down-regulated 1. (513 aa)
TRABD2BTraB domain containing 2B. (483 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
RNF213Ring finger protein 213. (5256 aa)
NKD1EF-hand domain-containing protein. (634 aa)
FERMT1Fermitin family member 1. (677 aa)
CSNK1A1LCasein kinase 1 alpha 1 like; Belongs to the protein kinase superfamily. (337 aa)
GRB10Growth factor receptor bound protein 10. (594 aa)
MDKMidkine. (143 aa)
LIMD1LIM domains containing 1. (676 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
NFATC4Nuclear factor of activated T cells 4. (963 aa)
NPHP4Nephrocystin 4. (1426 aa)
MLLT3MLLT3 super elongation complex subunit. (566 aa)
TLE3TLE family member 3, transcriptional corepressor. (774 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
ENSPPAP00000008445TLE_N domain-containing protein. (90 aa)
EMDEmerin. (254 aa)
STK4Serine/threonine kinase 4. (487 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
G3BP1G3BP stress granule assembly factor 1. (466 aa)
JADE1Jade family PHD finger 1. (857 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
HMGXB4HMG-box containing 4. (600 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (271 aa)
DKKL1Dickkopf like acrosomal protein 1. (242 aa)
SHISA3Shisa family member 3. (238 aa)
UBAC2UBA domain containing 2. (344 aa)
SOX10SRY-box transcription factor 10. (466 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
ANKRD6Ankyrin repeat domain 6. (727 aa)
TBX18T-box transcription factor 18. (607 aa)
ENSPPAP00000011186Homeobox domain-containing protein. (218 aa)
INVSInversin. (1029 aa)
DAB2DAB adaptor protein 2. (752 aa)
LOC100981302FERM domain-containing protein. (452 aa)
SOX13SRY-box transcription factor 13. (622 aa)
LRP1LDL receptor related protein 1. (4544 aa)
TLE6TLE family member 6, subcortical maternal complex member. (538 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
TCF7L2Transcription factor 7 like 2. (555 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
WIF1WNT inhibitory factor 1. (379 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (470 aa)
FOXO1Fork-head domain-containing protein. (527 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
NFATC1Nuclear factor of activated T cells 1. (975 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1602 aa)
NKX2-5NK2 homeobox 5. (325 aa)
AXIN1Axin 1. (862 aa)
CBY1Chibby family member 1, beta catenin antagonist. (169 aa)
SFRP5Secreted frizzled related protein 5. (311 aa)
RBX1Ring-box 1. (108 aa)
FRZBFrizzled related protein. (325 aa)
ENSPPAP00000017361Uncharacterized protein. (81 aa)
CCDC88CCoiled-coil domain containing 88C. (2019 aa)
SHISA2Shisa family member 2. (280 aa)
SCYL2SCY1 like pseudokinase 2. (933 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
TMEM64Transmembrane protein 64. (320 aa)
ENSPPAP00000019393Protein kinase domain-containing protein. (777 aa)
AMER2Uncharacterized protein. (466 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
DKK4Dickkopf WNT signaling pathway inhibitor 4. (224 aa)
SFRP4Secreted frizzled related protein 4. (368 aa)
TSC2TSC complex subunit 2. (1807 aa)
TMEM170BTransmembrane protein 170B. (132 aa)
AXIN2Axin 2. (843 aa)
ISL1ISL LIM homeobox 1. (349 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
SFRP1NTR domain-containing protein. (178 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (289 aa)
RNF43RING-type domain-containing protein. (783 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (416 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (750 aa)
ENSPPAP00000022866Uncharacterized protein. (127 aa)
LOC100975570Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (428 aa)
BICC1BicC family RNA binding protein 1. (959 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
CTNNB1Catenin beta 1. (781 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
TMEM88Transmembrane protein 88. (159 aa)
VGLL4Vestigial like family member 4. (296 aa)
ENSPPAP00000025550CXXC-type domain-containing protein. (173 aa)
TMEM131LTransmembrane 131 like. (1617 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
APCDD1LAPC down-regulated 1 like. (601 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
FRMD8FERM domain containing 8. (464 aa)
NOTUMUncharacterized protein. (252 aa)
RBMS3RNA binding motif single stranded interacting protein 3. (437 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (463 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
TLE1TLE family member 1, transcriptional corepressor. (779 aa)
PFDN5Prefoldin subunit 5. (154 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
NPPANatriuretic peptide A. (153 aa)
ENSPPAP00000029665Uncharacterized protein. (115 aa)
MDFIMyoD family inhibitor. (246 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
TLE2TLE family member 2, transcriptional corepressor. (606 aa)
SOSTSclerostin. (213 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
DAB2IPDAB2 interacting protein. (1155 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
ENSPPAP00000033311Protein kinase domain-containing protein. (305 aa)
NOTCH1Notch receptor 1. (2573 aa)
TNNTenascin N. (1299 aa)
TRABD2ATraB domain containing 2A. (505 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
ENSPPAP00000034340NTF2 domain-containing protein. (394 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2573 aa)
IGFBP1Insulin like growth factor binding protein 1. (275 aa)
TLE4TLE family member 4, transcriptional corepressor. (790 aa)
NXNThioredoxin domain-containing protein. (328 aa)
GSCHomeobox protein goosecoid; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity); Belongs to the paired homeobox family. Bicoid subfamily. (257 aa)
STK3Serine/threonine kinase 3. (467 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
LATS2Non-specific serine/threonine protein kinase. (1088 aa)
SOX2SRY-box transcription factor 2. (299 aa)
DACT3Uncharacterized protein. (180 aa)
AMFRAutocrine motility factor receptor. (564 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (365 aa)
TLE7TLE family member 7. (414 aa)
IFT80Intraflagellar transport 80. (771 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (350 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
CTNND1Catenin delta 1. (975 aa)
PRICKLE1Prickle planar cell polarity protein 1. (831 aa)
SOX30SRY-box transcription factor 30. (753 aa)
GLI3GLI family zinc finger 3. (1580 aa)
OTUD5OTU domain-containing protein. (349 aa)
GLI1GLI family zinc finger 1. (1106 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (489 aa)
LRP4LDL receptor related protein 4. (1857 aa)
C12orf43Chromosome 12 open reading frame 43. (263 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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