STRINGSTRING
HIF1A HIF1A ATP2B1 ATP2B1 ACVR2A ACVR2A LRP4 LRP4 DHRS3 DHRS3 TFAP2A TFAP2A ACVR2B ACVR2B OMD OMD MGP MGP CSF1 CSF1 PHOSPHO1 PHOSPHO1 BGLAP BGLAP RXRA RXRA PKDCC PKDCC RBPJ RBPJ MAPK14 MAPK14 KREMEN2 KREMEN2 GDF10 GDF10 RFLNB RFLNB SGMS2 SGMS2 FBN2 FBN2 ALOX5 ALOX5 COMP COMP CHSY1 CHSY1 SIX2 SIX2 CALCA CALCA FAM20C FAM20C BMPR1A BMPR1A NOTCH1 NOTCH1 MEF2C MEF2C SOST SOST TPH1 TPH1 RXRB RXRB GPM6B GPM6B NIPBL NIPBL PTK2B PTK2B MAPK3 MAPK3 NELL1 NELL1 ENSPPAP00000029143 ENSPPAP00000029143 VDR VDR ACVR1 ACVR1 ESRRA ESRRA ADRB2 ADRB2 LTBP3 LTBP3 ATRAID ATRAID ANO6 ANO6 RUNX2 RUNX2 NOTUM NOTUM EGR2 EGR2 CCN1 CCN1 STATH STATH PTPN11 PTPN11 WNT10B WNT10B ENSPPAP00000024034 ENSPPAP00000024034 ADGRV1 ADGRV1 ZMPSTE24 ZMPSTE24 GATA1 GATA1 ENSPPAP00000022875 ENSPPAP00000022875 ZBTB16 ZBTB16 SCUBE2 SCUBE2 ENSPPAP00000022634 ENSPPAP00000022634 DKK1 DKK1 SFRP1 SFRP1 TXLNG TXLNG IFITM5 IFITM5 FGF23 FGF23 SMAD3 SMAD3 INTU INTU PTN PTN OSR1 OSR1 BMP7 BMP7 OSR2 OSR2 BCL2 BCL2 TGFB3 TGFB3 TRPM4 TRPM4 ECM1 ECM1 TGFB1 TGFB1 ENPP1 ENPP1 SMAD7 SMAD7 CYP27B1 CYP27B1 AHSG AHSG DDR2 DDR2 NBR1 NBR1 KREMEN1 KREMEN1 TGFB2 TGFB2 BMP2 BMP2 ISG15 ISG15 KL KL PTGER4 PTGER4 PTH PTH ANKH ANKH BMP4 BMP4 FZD9 FZD9 TENT5A TENT5A ENSPPAP00000009275 ENSPPAP00000009275 ENSPPAP00000009163 ENSPPAP00000009163 SRGN SRGN SMAD6 SMAD6 TACR1 TACR1 BCOR BCOR WNT5A WNT5A ENSPPAP00000006969 ENSPPAP00000006969 CALCR CALCR CCR1 CCR1 MAPK1 MAPK1 BMP2K BMP2K BMPR1B BMPR1B MDK MDK RFLNA RFLNA LTF LTF PHOSPHO2 PHOSPHO2 ACTN3 ACTN3 P2RX7 P2RX7 BMPR2 BMPR2 ENSPPAP00000003978 ENSPPAP00000003978 S1PR1 S1PR1 PBX1 PBX1 WNT4 WNT4 TMEM119 TMEM119 MATN1 MATN1 BMP6 BMP6 SLC8A1 SLC8A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
LRP4LDL receptor related protein 4. (1857 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
TFAP2ATF_AP-2 domain-containing protein. (328 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
OMDOsteomodulin. (436 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (92 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (549 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (267 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (100 aa)
RXRARetinoid X receptor alpha. (472 aa)
PKDCCProtein kinase domain-containing protein. (475 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (499 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
KREMEN2Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
RFLNBRefilin B. (144 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
FBN2Fibrillin 2. (2866 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
COMPCartilage oligomeric matrix protein. (762 aa)
CHSY1Hexosyltransferase. (772 aa)
SIX2SIX homeobox 2. (291 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
FAM20CFam20C domain-containing protein. (475 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NOTCH1Notch receptor 1. (2573 aa)
MEF2CMyocyte enhancer factor 2C. (482 aa)
SOSTSclerostin. (213 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
RXRBRetinoid X receptor beta. (537 aa)
GPM6BGlycoprotein M6B. (305 aa)
NIPBLNipped-B protein. (2804 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (311 aa)
NELL1Neural EGFL like 1. (838 aa)
ENSPPAP00000029143Uncharacterized protein. (511 aa)
VDRVitamin D receptor. (477 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
ADRB2Adrenoceptor beta 2. (429 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1270 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (284 aa)
ANO6Anoctamin. (906 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
NOTUMUncharacterized protein. (252 aa)
EGR2Early growth response 2. (476 aa)
CCN1Cellular communication network factor 1. (381 aa)
STATHStatherin. (62 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ENSPPAP00000024034Uncharacterized protein. (541 aa)
ADGRV1Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family. (6306 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (484 aa)
GATA1GATA binding protein 1. (413 aa)
ENSPPAP00000022875Uncharacterized protein. (107 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (980 aa)
ENSPPAP00000022634Uncharacterized protein. (396 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (289 aa)
SFRP1NTR domain-containing protein. (178 aa)
TXLNGTaxilin gamma. (502 aa)
IFITM5Interferon induced transmembrane protein 5. (132 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
INTUInturned planar cell polarity protein. (931 aa)
PTNPleiotrophin. (172 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
OSR2Odd-skipped related transciption factor 2. (433 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1138 aa)
ECM1Extracellular matrix protein 1. (540 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (949 aa)
SMAD7MH2 domain-containing protein. (211 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
AHSGAlpha 2-HS glycoprotein. (367 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
NBR1NBR1 autophagy cargo receptor. (988 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (470 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
ISG15ISG15 ubiquitin like modifier. (165 aa)
KLKlotho. (1032 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (475 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (517 aa)
TENT5ATerminal nucleotidyltransferase 5A. (452 aa)
ENSPPAP00000009275Uncharacterized protein. (269 aa)
ENSPPAP00000009163Uncharacterized protein. (232 aa)
SRGNSerglycin. (162 aa)
SMAD6Mothers against decapentaplegic homolog. (495 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
BCORBCL6 corepressor. (1755 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
ENSPPAP00000006969Uncharacterized protein. (584 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
BMP2KBMP2 inducible kinase. (1091 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MDKMidkine. (143 aa)
RFLNARefilin A. (135 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
PHOSPHO2Phosphatase, orphan 2. (241 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (944 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
ENSPPAP00000003978Uncharacterized protein. (126 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
PBX1PBX homeobox 1. (462 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
TMEM119Transmembrane protein 119. (283 aa)
MATN1Matrilin 1. (496 aa)
BMP6Bone morphogenetic protein 6. (453 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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