(65 nodes) Cholesterol transport network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOAT2	O-acyltransferase. (526 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (673 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	LIPC	Lipase C, hepatic type. (490 aa)
	SCARB1	Uncharacterized protein; Belongs to the CD36 family. (498 aa)
	APOB	Apolipoprotein B. (4535 aa)
	OSBPL2	Oxysterol-binding protein; Belongs to the OSBP family. (480 aa)
	RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
	APOC3	Apolipoprotein C3. (99 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1277 aa)
	HNF1A	HNF1 homeobox A. (662 aa)
	TSKU	Tsukushi, small leucine rich proteoglycan. (353 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (295 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (646 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (651 aa)
	ABCA5	ATP binding cassette subfamily A member 5. (1631 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family. (267 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2595 aa)
	ABCG1	ABC transporter domain-containing protein. (807 aa)
	LDLR	Low density lipoprotein receptor. (849 aa)
	LOC100984384	COesterase domain-containing protein. (369 aa)
	NPC1L1	NPC1 like intracellular cholesterol transporter 1. (1359 aa)
	LOC100979126	Uncharacterized protein; Belongs to the AAA ATPase family. (462 aa)
	CLU	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
	TPCN2	Two pore segment channel 2. (752 aa)
	LOC100980372	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (517 aa)
	SERAC1	Serine active site containing 1. (654 aa)
	AKR1C1	Aldo-keto reductase family 1 member C1. (295 aa)
	APOM	Apolipoprotein M. (188 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (446 aa)
	CEL	Carboxyl ester lipase. (660 aa)
	APOE	Apolipoprotein E. (317 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	LIPG	Lipase G, endothelial type. (500 aa)
	LOC103783188	Aldo_ket_red domain-containing protein. (205 aa)
	LCAT	Lecithin-cholesterol acyltransferase. (440 aa)
	MSR1	Macrophage scavenger receptor 1. (460 aa)
	APOA4	Apolipoprotein A4. (396 aa)
	OSBP	Oxysterol-binding protein; Belongs to the OSBP family. (757 aa)
	SPG11	SPG11 vesicle trafficking associated, spatacsin. (2443 aa)
	SOAT1	O-acyltransferase. (550 aa)
	LIMA1	LIM domain and actin binding 1. (760 aa)
	ABCA7	ATP binding cassette subfamily A member 7. (2146 aa)
	STARD3NL	STARD3 N-terminal like. (234 aa)
	NPC2	ML domain-containing protein. (221 aa)
	STARD4	StAR related lipid transfer domain containing 4. (209 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (466 aa)
	ABCA8	ATP binding cassette subfamily A member 8. (1621 aa)
	OSBPL5	Oxysterol-binding protein; Belongs to the OSBP family. (879 aa)
	STAR	Steroidogenic acute regulatory protein. (230 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2264 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1480 aa)
	APOA5	Apolipoprotein A5. (366 aa)
	STARD5	StAR related lipid transfer domain containing 5. (213 aa)
	LOC100993746	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (304 aa)
	STX12	Syntaxin 12; Belongs to the syntaxin family. (276 aa)
	ENSPPAP00000037156	Uncharacterized protein. (167 aa)
	SYT7	Uncharacterized protein. (686 aa)
	TSPO2	Translocator protein 2. (170 aa)
	APOC2	Uncharacterized protein. (178 aa)
	SCP2	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
	ARL8B	ADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family. (186 aa)
	ARV1	ARV1 homolog, fatty acid homeostasis modulator. (271 aa)
	STARD3	Uncharacterized protein. (494 aa)
	ENSPPAP00000043045	PIPK domain-containing protein. (255 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	ABCG1	ENSPPAP00000035173	ENSPPAP00000007960	ATP binding cassette subfamily A member 1.	ABC transporter domain-containing protein.	0.439
ABCA1	APOA1	ENSPPAP00000035173	ENSPPAP00000007656	ATP binding cassette subfamily A member 1.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	0.935
ABCA1	APOA5	ENSPPAP00000035173	ENSPPAP00000035458	ATP binding cassette subfamily A member 1.	Apolipoprotein A5.	0.467
ABCA1	APOB	ENSPPAP00000035173	ENSPPAP00000002804	ATP binding cassette subfamily A member 1.	Apolipoprotein B.	0.706
ABCA1	APOC2	ENSPPAP00000035173	ENSPPAP00000039494	ATP binding cassette subfamily A member 1.	Uncharacterized protein.	0.461
ABCA1	APOC3	ENSPPAP00000035173	ENSPPAP00000003943	ATP binding cassette subfamily A member 1.	Apolipoprotein C3.	0.634
ABCA1	APOE	ENSPPAP00000035173	ENSPPAP00000022762	ATP binding cassette subfamily A member 1.	Apolipoprotein E.	0.854
ABCA1	APOM	ENSPPAP00000035173	ENSPPAP00000019117	ATP binding cassette subfamily A member 1.	Apolipoprotein M.	0.409
ABCA1	CD36	ENSPPAP00000035173	ENSPPAP00000001139	ATP binding cassette subfamily A member 1.	CD36 molecule; Belongs to the CD36 family.	0.635
ABCA1	CETP	ENSPPAP00000035173	ENSPPAP00000033549	ATP binding cassette subfamily A member 1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.687
ABCA1	LCAT	ENSPPAP00000035173	ENSPPAP00000024974	ATP binding cassette subfamily A member 1.	Lecithin-cholesterol acyltransferase.	0.805
ABCA1	LIPC	ENSPPAP00000035173	ENSPPAP00000000089	ATP binding cassette subfamily A member 1.	Lipase C, hepatic type.	0.645
ABCA1	LIPG	ENSPPAP00000035173	ENSPPAP00000022858	ATP binding cassette subfamily A member 1.	Lipase G, endothelial type.	0.536
ABCA1	NPC1	ENSPPAP00000035173	ENSPPAP00000004222	ATP binding cassette subfamily A member 1.	NPC intracellular cholesterol transporter 1.	0.674
ABCA1	NPC1L1	ENSPPAP00000035173	ENSPPAP00000012162	ATP binding cassette subfamily A member 1.	NPC1 like intracellular cholesterol transporter 1.	0.624
ABCA1	NPC2	ENSPPAP00000035173	ENSPPAP00000032988	ATP binding cassette subfamily A member 1.	ML domain-containing protein.	0.428
ABCA1	SCARB1	ENSPPAP00000035173	ENSPPAP00000002618	ATP binding cassette subfamily A member 1.	Uncharacterized protein; Belongs to the CD36 family.	0.716
ABCA1	SOAT1	ENSPPAP00000035173	ENSPPAP00000031689	ATP binding cassette subfamily A member 1.	O-acyltransferase.	0.478
ABCA7	APOE	ENSPPAP00000032613	ENSPPAP00000022762	ATP binding cassette subfamily A member 7.	Apolipoprotein E.	0.644
ABCA7	CLU	ENSPPAP00000032613	ENSPPAP00000014461	ATP binding cassette subfamily A member 7.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.708