STRINGSTRING
SALL1 SALL1 LRP4 LRP4 HOXA13 HOXA13 TFAP2A TFAP2A HOXC11 HOXC11 GLI3 GLI3 WDR19 WDR19 LEF1 LEF1 C2CD3 C2CD3 GRHL2 GRHL2 IMPAD1 IMPAD1 RECK RECK ALX3 ALX3 FRAS1 FRAS1 TMEM107 TMEM107 PTCH1 PTCH1 RDH10 RDH10 IFT140 IFT140 FBN2 FBN2 TBC1D32 TBC1D32 BCL2L11 BCL2L11 MED1 MED1 DYNC2H1 DYNC2H1 FGF8 FGF8 BAX BAX PBX2 PBX2 BMPR1A BMPR1A TMEM231 TMEM231 RPGRIP1L RPGRIP1L NOTCH1 NOTCH1 HOXD9 HOXD9 TBX4 TBX4 PSEN1 PSEN1 LMBR1 LMBR1 CREBBP CREBBP RARB RARB NIPBL NIPBL HOXA11 HOXA11 SALL4 SALL4 FLVCR1 FLVCR1 TP63 TP63 WNT3 WNT3 CPLANE1 CPLANE1 RUNX2 RUNX2 SP8 SP8 HOXD10 HOXD10 CTNNB1 CTNNB1 IFT52 IFT52 FZD6 FZD6 HOXC10 HOXC10 ENSPPAP00000024018 ENSPPAP00000024018 ZBTB16 ZBTB16 DKK1 DKK1 IHH IHH ALDH1A2 ALDH1A2 FREM2 FREM2 SHH SHH CHD7 CHD7 GNAS-2 GNAS-2 INTU INTU HDAC2 HDAC2 MSX1 MSX1 WDPCP WDPCP OSR1 OSR1 BMP7 BMP7 OSR2 OSR2 HDAC1 HDAC1 AFF3 AFF3 CYP26B1 CYP26B1 MBNL1 MBNL1 CACNA1C CACNA1C PRRX1 PRRX1 DLX5 DLX5 TBX2 TBX2 TGFB2 TGFB2 SKI SKI DLX6 DLX6 LNPK LNPK WNT7A WNT7A NOTCH2 NOTCH2 CHST11 CHST11 TULP3 TULP3 TBX5 TBX5 RSPO2 RSPO2 RARG RARG MYH3 MYH3 BMP4 BMP4 TBX3 TBX3 ECE1 ECE1 HOXA10 HOXA10 ENSPPAP00000009786 ENSPPAP00000009786 SMAD4 SMAD4 LRP5 LRP5 B9D1 B9D1 WNT5A WNT5A CRABP2 CRABP2 MEGF8 MEGF8 MKS1 MKS1 FBXW4 FBXW4 ACD ACD SHOX2 SHOX2 PITX1 PITX1 ENSPPAP00000004903 ENSPPAP00000004903 HNF1A HNF1A GDF5 GDF5 HOXD12 HOXD12 ZNF358 ZNF358 PBX1 PBX1 HAND2 HAND2 HOXD13 HOXD13 NOG NOG FGF9 FGF9 MAP3K20 MAP3K20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SALL1Spalt like transcription factor 1. (1306 aa)
LRP4LDL receptor related protein 4. (1857 aa)
HOXA13Homeobox domain-containing protein. (209 aa)
TFAP2ATF_AP-2 domain-containing protein. (328 aa)
HOXC11Homeobox C11. (304 aa)
GLI3GLI family zinc finger 3. (1580 aa)
WDR19WD repeat domain 19. (1341 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
C2CD3Uncharacterized protein. (1886 aa)
GRHL2Grainyhead like transcription factor 2. (618 aa)
IMPAD1Inositol monophosphatase domain containing 1. (357 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (970 aa)
ALX3ALX homeobox 3. (295 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4012 aa)
TMEM107Transmembrane protein 107. (146 aa)
PTCH1Patched 1. (1446 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
IFT140Intraflagellar transport 140. (1457 aa)
FBN2Fibrillin 2. (2866 aa)
TBC1D32TBC1 domain family member 32. (1298 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1555 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4314 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
PBX2PBX homeobox 2. (414 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TMEM231Transmembrane protein 231. (345 aa)
RPGRIP1LRPGRIP1 like. (1309 aa)
NOTCH1Notch receptor 1. (2573 aa)
HOXD9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (324 aa)
TBX4T-box transcription factor 4. (545 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (490 aa)
CREBBPCREB binding protein. (2414 aa)
RARBRetinoic acid receptor beta. (448 aa)
NIPBLNipped-B protein. (2804 aa)
HOXA11Homeobox A11. (327 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (569 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3197 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
SP8Uncharacterized protein. (370 aa)
HOXD10Homeobox D10. (410 aa)
CTNNB1Catenin beta 1. (781 aa)
IFT52Intraflagellar transport 52. (437 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
HOXC10Homeobox C10. (342 aa)
ENSPPAP00000024018Uncharacterized protein. (1204 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (289 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (402 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
FREM2FRAS1 related extracellular matrix 2. (3169 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
GNAS-2Uncharacterized protein. (245 aa)
INTUInturned planar cell polarity protein. (931 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (510 aa)
MSX1Msh homeobox 1. (249 aa)
WDPCPWD repeat containing planar cell polarity effector. (746 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
OSR2Odd-skipped related transciption factor 2. (433 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
AFF3AF4/FMR2 family member 3. (1192 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (495 aa)
MBNL1Muscleblind like splicing regulator 1. (400 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
PRRX1Paired related homeobox 1. (245 aa)
DLX5Distal-less homeobox 5. (289 aa)
TBX2T-box transcription factor 2. (622 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SKISKI proto-oncogene. (666 aa)
DLX6Homeobox domain-containing protein. (165 aa)
LNPKLunapark, ER junction formation factor. (459 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
NOTCH2Notch receptor 2. (2254 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
TULP3TUB like protein 3; Belongs to the TUB family. (501 aa)
TBX5T-box transcription factor 5. (518 aa)
RSPO2R-spondin 2. (243 aa)
RARGRetinoic acid receptor gamma. (464 aa)
MYH3Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1942 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
TBX3T-box transcription factor 3. (723 aa)
ECE1Endothelin converting enzyme 1. (770 aa)
HOXA10Homeobox A10. (398 aa)
ENSPPAP00000009786Homeobox domain-containing protein. (168 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LRP5LDL receptor related protein 5. (1839 aa)
B9D1B9 domain containing 1. (204 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
MEGF8Multiple EGF like domains 8. (2845 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
FBXW4F-box and WD repeat domain containing 4. (395 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (458 aa)
SHOX2Short stature homeobox 2. (355 aa)
PITX1Homeobox protein. (297 aa)
ENSPPAP00000004903Uncharacterized protein. (305 aa)
HNF1AHNF1 homeobox A. (662 aa)
GDF5Growth differentiation factor 5. (501 aa)
HOXD12Homeobox D12. (270 aa)
ZNF358Zinc finger protein 358. (553 aa)
PBX1PBX homeobox 1. (462 aa)
HAND2Uncharacterized protein. (66 aa)
HOXD13Homeobox domain-containing protein. (230 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (803 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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