(25 nodes) Regulation of complement activation network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	LOC100968163	Uncharacterized protein. (579 aa)
	ENSPPAP00000042813	Prohibitin. (250 aa)
	CD5L	CD5 molecule like. (347 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	CR1	Uncharacterized protein. (582 aa)
	CSMD3	CUB and Sushi multiple domains 3. (3707 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	C4BPA	Complement component 4 binding protein alpha. (597 aa)
	SERPING1	Serpin family G member 1; Belongs to the serpin family. (496 aa)
	ENSPPAP00000030479	Prohibitin. (194 aa)
	CD59	UPAR/Ly6 domain-containing protein. (152 aa)
	MASP1	Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (728 aa)
	C3	Complement C3. (1614 aa)
	SUSD4	Sushi domain containing 4. (489 aa)
	C4BPB	Complement component 4 binding protein beta. (252 aa)
	VSIG4	V-set and immunoglobulin domain containing 4. (399 aa)
	LOC100992972	Uncharacterized protein. (1435 aa)
	ENSPPAP00000017085	Prohibitin. (177 aa)
	CFH	Complement factor H. (1065 aa)
	C1QBP	Complement C1q binding protein. (282 aa)
	LOC100989808	Prohibitin. (258 aa)
	A2M	Alpha-2-macroglobulin. (1474 aa)
	PHB	Prohibitin. (272 aa)
	CR2	Complement C3d receptor 2. (969 aa)
	CR1L	Complement C3b/C4b receptor 1 like. (569 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A2M	C4BPA	ENSPPAP00000008547	ENSPPAP00000034407	Alpha-2-macroglobulin.	Complement component 4 binding protein alpha.	0.460
A2M	CFH	ENSPPAP00000008547	ENSPPAP00000014351	Alpha-2-macroglobulin.	Complement factor H.	0.610
A2M	IL1B	ENSPPAP00000008547	ENSPPAP00000034853	Alpha-2-macroglobulin.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.817
A2M	SERPING1	ENSPPAP00000008547	ENSPPAP00000033295	Alpha-2-macroglobulin.	Serpin family G member 1; Belongs to the serpin family.	0.730
C1QBP	C3	ENSPPAP00000013966	ENSPPAP00000025770	Complement C1q binding protein.	Complement C3.	0.485
C1QBP	ENSPPAP00000017085	ENSPPAP00000013966	ENSPPAP00000017085	Complement C1q binding protein.	Prohibitin.	0.665
C1QBP	ENSPPAP00000030479	ENSPPAP00000013966	ENSPPAP00000030479	Complement C1q binding protein.	Prohibitin.	0.665
C1QBP	ENSPPAP00000042813	ENSPPAP00000013966	ENSPPAP00000042813	Complement C1q binding protein.	Prohibitin.	0.665
C1QBP	LOC100989808	ENSPPAP00000013966	ENSPPAP00000010684	Complement C1q binding protein.	Prohibitin.	0.665
C1QBP	PHB	ENSPPAP00000013966	ENSPPAP00000007416	Complement C1q binding protein.	Prohibitin.	0.692
C1QBP	SERPING1	ENSPPAP00000013966	ENSPPAP00000033295	Complement C1q binding protein.	Serpin family G member 1; Belongs to the serpin family.	0.688
C3	C1QBP	ENSPPAP00000025770	ENSPPAP00000013966	Complement C3.	Complement C1q binding protein.	0.485
C3	C4BPA	ENSPPAP00000025770	ENSPPAP00000034407	Complement C3.	Complement component 4 binding protein alpha.	0.797
C3	C4BPB	ENSPPAP00000025770	ENSPPAP00000021827	Complement C3.	Complement component 4 binding protein beta.	0.545
C3	CD59	ENSPPAP00000025770	ENSPPAP00000027336	Complement C3.	UPAR/Ly6 domain-containing protein.	0.717
C3	CFH	ENSPPAP00000025770	ENSPPAP00000014351	Complement C3.	Complement factor H.	0.999
C3	CR1	ENSPPAP00000025770	ENSPPAP00000036406	Complement C3.	Uncharacterized protein.	0.956
C3	CR1L	ENSPPAP00000025770	ENSPPAP00000001835	Complement C3.	Complement C3b/C4b receptor 1 like.	0.974
C3	CR2	ENSPPAP00000025770	ENSPPAP00000006788	Complement C3.	Complement C3d receptor 2.	0.994
C3	IL1B	ENSPPAP00000025770	ENSPPAP00000034853	Complement C3.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.528