STRINGSTRING
NODAL NODAL BMP7 BMP7 MSX1 MSX1 CHRDL1 CHRDL1 SMAD3 SMAD3 GDF3 GDF3 ZNF831 ZNF831 SFRP1 SFRP1 SOSTDC1 SOSTDC1 CHRD CHRD SMAD2 SMAD2 GDF9 GDF9 ACVRL1 ACVRL1 GDF6 GDF6 ABL1 ABL1 RUNX2 RUNX2 ACVR1 ACVR1 SMAD5 SMAD5 FAM83G FAM83G BMPER BMPER MAPK3 MAPK3 SPART SPART GDF15 GDF15 ETV2 ETV2 SOST SOST SMPD3 SMPD3 BMPR1A BMPR1A USP9X USP9X HJV HJV COMP COMP PDCD4 PDCD4 DSG4 DSG4 GDF7 GDF7 CCDC142 CCDC142 BMP10 BMP10 HFE HFE DDX5 DDX5 SLC39A5 SLC39A5 LEF1 LEF1 ACVR2B ACVR2B TMPRSS6 TMPRSS6 ACVR2A ACVR2A USP15 USP15 HES1 HES1 BMP6 BMP6 DLX3 DLX3 BMP15 BMP15 BMP5 BMP5 NOG NOG GDF2 GDF2 FKBP8 FKBP8 BMPR2 BMPR2 GDF5 GDF5 RGMB RGMB SCX SCX EXT1 EXT1 BMPR1B BMPR1B ZCCHC12 ZCCHC12 FST FST MEGF8 MEGF8 TGFBR3 TGFBR3 WNT5A WNT5A SMAD1 SMAD1 ATF2 ATF2 SMAD6 SMAD6 SMAD4 SMAD4 ZCCHC18 ZCCHC18 RGMA RGMA TWSG1 TWSG1 BMP4 BMP4 SLC33A1 SLC33A1 PPARG PPARG SMAD9 SMAD9 HIVEP1 HIVEP1 ZNF8 ZNF8 EGR1 EGR1 LEFTY2 LEFTY2 NOTCH2 NOTCH2 BMP2 BMP2 TGFB2 TGFB2 BMP8A BMP8A DLX5 DLX5 ENG ENG SMAD7 SMAD7 TGFB1 TGFB1 LEFTY1 LEFTY1 TGFB3 TGFB3 SMURF1 SMURF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NODALNodal growth differentiation factor. (347 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
MSX1Msh homeobox 1. (249 aa)
CHRDL1Chordin like 1. (458 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
GDF3Growth differentiation factor 3. (364 aa)
ZNF831Zinc finger protein 831. (1676 aa)
SFRP1NTR domain-containing protein. (178 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (942 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
GDF9Growth differentiation factor 9. (367 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
GDF6TGF_BETA_2 domain-containing protein. (370 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
FAM83GFamily with sequence similarity 83 member G. (823 aa)
BMPERBMP binding endothelial regulator. (685 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (311 aa)
SPARTSpartin. (665 aa)
GDF15Growth differentiation factor 15. (308 aa)
ETV2ETS variant 2. (342 aa)
SOSTSclerostin. (213 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (638 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2576 aa)
HJVHemojuvelin BMP co-receptor. (425 aa)
COMPCartilage oligomeric matrix protein. (762 aa)
PDCD4Programmed cell death 4. (469 aa)
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1059 aa)
GDF7TGF_BETA_2 domain-containing protein. (361 aa)
CCDC142Coiled-coil domain containing 142. (743 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
SLC39A5Solute carrier family 39 member 5. (540 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (824 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
BMP6Bone morphogenetic protein 6. (453 aa)
DLX3Distal-less homeobox 3. (287 aa)
BMP15Bone morphogenetic protein 15. (369 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
GDF2Growth differentiation factor 2. (429 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
GDF5Growth differentiation factor 5. (501 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (428 aa)
SCXBHLH domain-containing protein. (111 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZCCHC12Zinc finger CCHC-type containing 12. (402 aa)
FSTUncharacterized protein. (409 aa)
MEGF8Multiple EGF like domains 8. (2845 aa)
TGFBR3Transforming growth factor beta receptor 3. (861 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SMAD6Mothers against decapentaplegic homolog. (495 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ZCCHC18Zinc finger CCHC-type containing 18. (385 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
SLC33A1Solute carrier family 33 member 1. (549 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
HIVEP1Human immunodeficiency virus type I enhancer binding protein 1. (2690 aa)
ZNF8Zinc finger protein 8. (575 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
LEFTY2Left-right determination factor. (366 aa)
NOTCH2Notch receptor 2. (2254 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMP8ATGF_BETA_2 domain-containing protein. (239 aa)
DLX5Distal-less homeobox 5. (289 aa)
ENGEndoglin. (658 aa)
SMAD7MH2 domain-containing protein. (211 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LEFTY1Left-right determination factor 1. (325 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SMURF1E3 ubiquitin-protein ligase. (752 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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