(25 nodes) Male genitalia development network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (982 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	ASB1	Ankyrin repeat and SOCS box containing 1. (336 aa)
	ENSPPAP00000029857	Uncharacterized protein. (138 aa)
	SRD5A1	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
	AR	Androgen receptor. (882 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	HSD17B3	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
	HOXA13	Homeobox domain-containing protein. (209 aa)
	BMP6	Bone morphogenetic protein 6. (453 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	HOXD13	Homeobox domain-containing protein. (230 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1924 aa)
	TBX3	T-box transcription factor 3. (723 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (935 aa)
	GREB1	Growth regulating estrogen receptor binding 1. (1926 aa)
	SYCP2	Synaptonemal complex protein 2. (1517 aa)
	KLHL10	Kelch like family member 10. (608 aa)
	LHCGR	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (699 aa)
	SRD5A2	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (495 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
	WT1	Uncharacterized protein. (429 aa)
	DHCR24	24-dehydrocholesterol reductase. (516 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CTNNB1	ENSPPAP00000031741	ENSPPAP00000024694	Androgen receptor.	Catenin beta 1.	0.968
AR	HSD17B3	ENSPPAP00000031741	ENSPPAP00000034904	Androgen receptor.	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.468
AR	SRD5A2	ENSPPAP00000031741	ENSPPAP00000018992	Androgen receptor.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.630
BMP5	FGF8	ENSPPAP00000001212	ENSPPAP00000034277	Bone morphogenetic protein 5.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.448
CTNNB1	AR	ENSPPAP00000024694	ENSPPAP00000031741	Catenin beta 1.	Androgen receptor.	0.968
CTNNB1	FGF10	ENSPPAP00000024694	ENSPPAP00000032835	Catenin beta 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.521
CTNNB1	FGF8	ENSPPAP00000024694	ENSPPAP00000034277	Catenin beta 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.639
CTNNB1	LGR4	ENSPPAP00000024694	ENSPPAP00000011107	Catenin beta 1.	Leucine rich repeat containing G protein-coupled receptor 4.	0.505
CTNNB1	ROR2	ENSPPAP00000024694	ENSPPAP00000022840	Catenin beta 1.	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.459
CTNNB1	SHH	ENSPPAP00000024694	ENSPPAP00000020557	Catenin beta 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.725
CTNNB1	WNT9B	ENSPPAP00000024694	ENSPPAP00000019910	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.551
CTNNB1	WT1	ENSPPAP00000024694	ENSPPAP00000021187	Catenin beta 1.	Uncharacterized protein.	0.499
DHCR24	HSD17B3	ENSPPAP00000023689	ENSPPAP00000034904	24-dehydrocholesterol reductase.	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.562
ENSPPAP00000029857	HSD17B3	ENSPPAP00000029857	ENSPPAP00000034904	Uncharacterized protein.	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.546
FGF10	CTNNB1	ENSPPAP00000032835	ENSPPAP00000024694	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Catenin beta 1.	0.521
FGF10	FGF8	ENSPPAP00000032835	ENSPPAP00000034277	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.501
FGF10	SHH	ENSPPAP00000032835	ENSPPAP00000020557	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.761
FGF10	TBX3	ENSPPAP00000032835	ENSPPAP00000010916	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	T-box transcription factor 3.	0.538
FGF8	BMP5	ENSPPAP00000034277	ENSPPAP00000001212	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 5.	0.448
FGF8	CTNNB1	ENSPPAP00000034277	ENSPPAP00000024694	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Catenin beta 1.	0.639