(19 nodes) Female genitalia development network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPPAP00000007855	Uncharacterized protein. (192 aa)
	LRP2	LDL receptor related protein 2. (4641 aa)
	LHX1	LIM homeobox 1. (406 aa)
	BAX	BCL2 associated X, apoptosis regulator. (218 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SRD5A1	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
	ENSPPAP00000030502	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (849 aa)
	ENSPPAP00000029857	Uncharacterized protein. (138 aa)
	AXL	AXL receptor tyrosine kinase. (894 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	STRA6	Stimulated by retinoic acid 6. (706 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2997 aa)
	SRD5A2	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
	MERTK	MER proto-oncogene, tyrosine kinase. (966 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	CYP19A1	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
	TBX3	T-box transcription factor 3. (723 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAK1	BAX	ENSPPAP00000012940	ENSPPAP00000034249	BCL2 antagonist/killer 1.	BCL2 associated X, apoptosis regulator.	0.957
BAX	BAK1	ENSPPAP00000034249	ENSPPAP00000012940	BCL2 associated X, apoptosis regulator.	BCL2 antagonist/killer 1.	0.957
BAX	ENSPPAP00000007855	ENSPPAP00000034249	ENSPPAP00000007855	BCL2 associated X, apoptosis regulator.	Uncharacterized protein.	0.594
CYP19A1	ENSPPAP00000029857	ENSPPAP00000012728	ENSPPAP00000029857	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.473
CYP19A1	ESR1	ENSPPAP00000012728	ENSPPAP00000006837	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.785
CYP19A1	SRD5A1	ENSPPAP00000012728	ENSPPAP00000030984	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.945
CYP19A1	SRD5A2	ENSPPAP00000012728	ENSPPAP00000018992	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.948
ENSPPAP00000007855	BAX	ENSPPAP00000007855	ENSPPAP00000034249	Uncharacterized protein.	BCL2 associated X, apoptosis regulator.	0.594
ENSPPAP00000029857	CYP19A1	ENSPPAP00000029857	ENSPPAP00000012728	Uncharacterized protein.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.473
ESR1	CYP19A1	ENSPPAP00000006837	ENSPPAP00000012728	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.785
ESR1	TBX3	ENSPPAP00000006837	ENSPPAP00000010916	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	T-box transcription factor 3.	0.476
FGF10	STRA6	ENSPPAP00000032835	ENSPPAP00000025538	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Stimulated by retinoic acid 6.	0.426
FGF10	TBX3	ENSPPAP00000032835	ENSPPAP00000010916	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	T-box transcription factor 3.	0.538
FGF10	WNT5A	ENSPPAP00000032835	ENSPPAP00000008134	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.400
LRP2	WNT5A	ENSPPAP00000038526	ENSPPAP00000008134	LDL receptor related protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.427
SRD5A1	CYP19A1	ENSPPAP00000030984	ENSPPAP00000012728	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.945
SRD5A1	SRD5A2	ENSPPAP00000030984	ENSPPAP00000018992	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.925
SRD5A2	CYP19A1	ENSPPAP00000018992	ENSPPAP00000012728	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.948
SRD5A2	SRD5A1	ENSPPAP00000018992	ENSPPAP00000030984	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.925
STRA6	FGF10	ENSPPAP00000025538	ENSPPAP00000032835	Stimulated by retinoic acid 6.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.426