STRINGSTRING
EGFR EGFR HIP1 HIP1 WNT5A WNT5A RAB35 RAB35 CLTB CLTB ATP6V1F ATP6V1F CLHC1 CLHC1 AFTPH AFTPH CLTC CLTC RAB3A RAB3A DAB2 DAB2 AVP AVP VAMP4 VAMP4 SYT1 SYT1 ENSPPAP00000012290 ENSPPAP00000012290 SLC2A8 SLC2A8 CD9 CD9 ENSPPAP00000013091 ENSPPAP00000013091 LOC100986750 LOC100986750 KIAA0319 KIAA0319 AP1G2 AP1G2 ATP6V1C1 ATP6V1C1 EPN2 EPN2 REEP6 REEP6 AP2A2 AP2A2 CLTCL1 CLTCL1 ENSPPAP00000015368 ENSPPAP00000015368 VAMP8 VAMP8 AP2B1 AP2B1 AP1G1 AP1G1 AP1S1 AP1S1 ENSPPAP00000016619 ENSPPAP00000016619 DBNL DBNL HLA-DPA1 HLA-DPA1 SLC18A3 SLC18A3 ATP6V0E2 ATP6V0E2 TYRP1 TYRP1 SYNRG SYNRG TGOLN2 TGOLN2 VAMP7 VAMP7 ATP6V1G2 ATP6V1G2 ENSPPAP00000019380 ENSPPAP00000019380 BTC BTC AP1B1 AP1B1 ENSPPAP00000020911 ENSPPAP00000020911 SCARB2 SCARB2 GAD2 GAD2 CLINT1 CLINT1 ROR2 ROR2 ATP6V0A1 ATP6V0A1 AVPR2 AVPR2 SYT2 SYT2 AP2M1 AP2M1 ATP6AP1 ATP6AP1 AP3B2 AP3B2 ADRB2 ADRB2 ENSPPAP00000027450 ENSPPAP00000027450 M6PR M6PR LOC100981595 LOC100981595 ENSPPAP00000028140 ENSPPAP00000028140 CD74 CD74 ADCY8 ADCY8 ATP6V1E1 ATP6V1E1 HLA-DQA2 HLA-DQA2 SLC32A1 SLC32A1 ATP6V1H ATP6V1H SLC18A1 SLC18A1 LOC100993847 LOC100993847 MYO6 MYO6 DENND1A DENND1A NCALD NCALD AP3B1 AP3B1 HIP1R HIP1R CEMIP CEMIP SYT11 SYT11 RNASEK RNASEK HBEGF HBEGF CLBA1 CLBA1 IL7R IL7R ATP6V0B ATP6V0B ENSPPAP00000033799 ENSPPAP00000033799 EPN1 EPN1 ENSPPAP00000033875 ENSPPAP00000033875 FCGR1A FCGR1A ATP6V0D1 ATP6V0D1 FZD4 FZD4 ATP6AP2 ATP6AP2 CLTA CLTA ENSPPAP00000035589 ENSPPAP00000035589 AP1S3 AP1S3 HSPA8 HSPA8 HLA-DQB1 HLA-DQB1 EPN3 EPN3 HLA-DQB2 HLA-DQB2 ATP6V0C ATP6V0C HLA-DPB1 HLA-DPB1 SYT9 SYT9 SGIP1 SGIP1 RAB5A RAB5A ATP6V1A ATP6V1A HLA-DRA HLA-DRA AP1M1 AP1M1 LRP2 LRP2 SLC17A7 SLC17A7 AREG AREG AP1S2 AP1S2 EREG EREG AP1M2 AP1M2 NECAP2 NECAP2 TGFA TGFA NECAP1 NECAP1 ATP6V1B2 ATP6V1B2 EPGN EPGN LDLR LDLR LDLRAP1 LDLRAP1 CD3G CD3G CD207 CD207 AP2A1 AP2A1 DNAJC5 DNAJC5 IGF2R IGF2R ENTHD1 ENTHD1 ENSPPAP00000005201 ENSPPAP00000005201 TFRC TFRC SH3GL2 SH3GL2 RASSF9 RASSF9 SLC18A2 SLC18A2 VAMP3 VAMP3 ATP6V1D ATP6V1D CD3D CD3D LOC100990258 LOC100990258 APOB APOB LOC100978544 LOC100978544 EGF EGF FZD5 FZD5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGFRReceptor protein-tyrosine kinase. (1201 aa)
HIP1Uncharacterized protein. (151 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
RAB35Uncharacterized protein. (348 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (180 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (147 aa)
CLHC1Clathrin heavy chain linker domain-containing protein 1. (586 aa)
AFTPHAftiphilin. (937 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
RAB3ARAB3A, member RAS oncogene family. (220 aa)
DAB2DAB adaptor protein 2. (752 aa)
AVPUncharacterized protein; Belongs to the vasopressin/oxytocin family. (134 aa)
VAMP4Vesicle associated membrane protein 4. (141 aa)
SYT1Synaptotagmin 1. (422 aa)
ENSPPAP00000012290Uncharacterized protein. (285 aa)
SLC2A8Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
CD9Tetraspanin. (228 aa)
ENSPPAP00000013091Uncharacterized protein. (176 aa)
LOC100986750Ig-like domain-containing protein. (287 aa)
KIAA0319KIAA0319. (1108 aa)
AP1G2AP-1 complex subunit gamma. (785 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
EPN2Epsin 2. (641 aa)
REEP6Receptor expression-enhancing protein. (184 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (943 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1639 aa)
ENSPPAP00000015368Uncharacterized protein; Belongs to the heat shock protein 70 family. (630 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
AP2B1AP complex subunit beta. (951 aa)
AP1G1AP-1 complex subunit gamma. (844 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
ENSPPAP00000016619Uncharacterized protein; Belongs to the heat shock protein 70 family. (564 aa)
DBNLDrebrin like. (489 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
SLC18A3Solute carrier family 18 member A3. (532 aa)
ATP6V0E2ATPase H+ transporting V0 subunit e2. (213 aa)
TYRP1Tyrosinase related protein 1. (537 aa)
SYNRGSynergin gamma. (1338 aa)
TGOLN2Uncharacterized protein. (522 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (260 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ENSPPAP00000019380DUF1681 domain-containing protein. (269 aa)
BTCBetacellulin. (178 aa)
AP1B1AP complex subunit beta. (947 aa)
ENSPPAP00000020911J domain-containing protein. (148 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (478 aa)
GAD2Glutamate decarboxylase 2. (580 aa)
CLINT1Clathrin interactor 1. (646 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (982 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (371 aa)
SYT2Synaptotagmin 2. (419 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (459 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (468 aa)
AP3B2AP-3 complex subunit beta. (1055 aa)
ADRB2Adrenoceptor beta 2. (429 aa)
ENSPPAP00000027450Uncharacterized protein. (77 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (277 aa)
LOC100981595Uncharacterized protein. (400 aa)
ENSPPAP00000028140Uncharacterized protein; Belongs to the heat shock protein 70 family. (501 aa)
CD74CD74 molecule. (296 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (226 aa)
HLA-DQA2Major histocompatibility complex, class II, DQ alpha 2; Belongs to the MHC class II family. (255 aa)
SLC32A1Solute carrier family 32 member 1. (525 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
SLC18A1Solute carrier family 18 member A1. (508 aa)
LOC100993847Ig-like domain-containing protein. (270 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1261 aa)
DENND1ADENN domain containing 1A. (1003 aa)
NCALDNeurocalcin delta. (193 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
HIP1RHuntingtin interacting protein 1 related. (1056 aa)
CEMIPCell migration inducing hyaluronidase 1. (1361 aa)
SYT11Synaptotagmin 11. (431 aa)
RNASEKRibonuclease K. (137 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
CLBA1Clathrin binding box of aftiphilin containing 1. (325 aa)
IL7RInterleukin 7 receptor. (459 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (261 aa)
ENSPPAP00000033799Uncharacterized protein. (195 aa)
EPN1Epsin 1. (642 aa)
ENSPPAP00000033875Uncharacterized protein. (84 aa)
FCGR1AUncharacterized protein. (368 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (392 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (350 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (236 aa)
ENSPPAP00000035589Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (88 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (163 aa)
HSPA8Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (261 aa)
EPN3Epsin 3. (630 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 2. (264 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
SYT9Synaptotagmin 9. (491 aa)
SGIP1SH3 domain GRB2 like endophilin interacting protein 1. (859 aa)
RAB5ARAB5A, member RAS oncogene family. (216 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (618 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
AP1M1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (424 aa)
LRP2LDL receptor related protein 2. (4641 aa)
SLC17A7Solute carrier family 17 member 7. (560 aa)
AREGEGF-like domain-containing protein. (274 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
EREGEpiregulin. (169 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (425 aa)
NECAP2NECAP endocytosis associated 2. (273 aa)
TGFATransforming growth factor alpha. (181 aa)
NECAP1NECAP endocytosis associated 1. (280 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (525 aa)
EPGNUncharacterized protein. (85 aa)
LDLRLow density lipoprotein receptor. (849 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (295 aa)
CD3GCD3g molecule. (182 aa)
CD207CD207 molecule. (328 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
DNAJC5DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
IGF2RInsulin like growth factor 2 receptor. (2464 aa)
ENTHD1ENTH domain containing 1. (607 aa)
ENSPPAP00000005201Clat_adaptor_s domain-containing protein. (54 aa)
TFRCTransferrin receptor. (773 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (337 aa)
RASSF9Ras association domain family member 9. (427 aa)
SLC18A2Solute carrier family 18 member A2. (514 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (116 aa)
ATP6V1DUncharacterized protein. (192 aa)
CD3DCD3d molecule. (171 aa)
LOC100990258V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
APOBApolipoprotein B. (4535 aa)
LOC100978544Uncharacterized protein. (893 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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