(48 nodes) Prostate gland development network (Pan paniscus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CRIP1	LIM zinc-binding domain-containing protein. (77 aa)
	RARG	Retinoic acid receptor gamma. (464 aa)
	BMP4	TGF_BETA_2 domain-containing protein. (402 aa)
	HOXA10	Homeobox A10. (398 aa)
	ENSPPAP00000009786	Homeobox domain-containing protein. (168 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (521 aa)
	HOXB13	Homeobox B13. (284 aa)
	ENSPPAP00000015326	HECT domain-containing protein. (670 aa)
	NKX3-1	NK3 homeobox 1. (223 aa)
	PSAPL1	Uncharacterized protein. (253 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	SERPINB5	Serpin family B member 5; Belongs to the serpin family. (375 aa)
	ENSPPAP00000003962	Uncharacterized protein. (69 aa)
	HOXD13	Homeobox domain-containing protein. (230 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	FKBP4	Peptidylprolyl isomerase. (456 aa)
	ENSPPAP00000017043	Peptidylprolyl isomerase. (371 aa)
	SERPINF1	Serpin family F member 1; Belongs to the serpin family. (418 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
	EAF2	ELL associated factor 2. (260 aa)
	ENSPPAP00000036589	Peptidylprolyl isomerase. (439 aa)
	MMP2	Matrix metallopeptidase 2. (664 aa)
	NOTCH1	Notch receptor 1. (2573 aa)
	LOC100995377	Uncharacterized protein. (557 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	WDR77	WD repeat domain 77. (352 aa)
	AR	Androgen receptor. (882 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (484 aa)
	HOXA11	Homeobox A11. (327 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (867 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	PSAP	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (534 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	FGFR2	Fibroblast growth factor receptor. (822 aa)
	SFRP1	NTR domain-containing protein. (178 aa)
	TNC	Tenascin C. (2201 aa)
	PTCH1	Patched 1. (1446 aa)
	FEM1B	Fem-1 homolog B. (627 aa)
	ANXA1	Annexin. (346 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	CYP19A1	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
	PTEN	Uncharacterized protein. (542 aa)
	PRLR	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
	PLAG1	PLAG1 zinc finger. (500 aa)
	GLI1	GLI family zinc finger 1. (1106 aa)
	RARA	Uncharacterized protein. (609 aa)
	HOXA13	Homeobox domain-containing protein. (209 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA1	CTNNB1	ENSPPAP00000014806	ENSPPAP00000024694	Annexin.	Catenin beta 1.	0.488
AR	CTNNB1	ENSPPAP00000031741	ENSPPAP00000024694	Androgen receptor.	Catenin beta 1.	0.968
AR	CYP19A1	ENSPPAP00000031741	ENSPPAP00000012728	Androgen receptor.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.574
AR	ENSPPAP00000015326	ENSPPAP00000031741	ENSPPAP00000015326	Androgen receptor.	HECT domain-containing protein.	0.549
AR	ENSPPAP00000017043	ENSPPAP00000031741	ENSPPAP00000017043	Androgen receptor.	Peptidylprolyl isomerase.	0.738
AR	ENSPPAP00000036589	ENSPPAP00000031741	ENSPPAP00000036589	Androgen receptor.	Peptidylprolyl isomerase.	0.738
AR	ESR1	ENSPPAP00000031741	ENSPPAP00000006837	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.834
AR	FKBP4	ENSPPAP00000031741	ENSPPAP00000001816	Androgen receptor.	Peptidylprolyl isomerase.	0.738
AR	GLI1	ENSPPAP00000031741	ENSPPAP00000041047	Androgen receptor.	GLI family zinc finger 1.	0.484
AR	HOXB13	ENSPPAP00000031741	ENSPPAP00000009139	Androgen receptor.	Homeobox B13.	0.676
AR	LOC100995377	ENSPPAP00000031741	ENSPPAP00000033339	Androgen receptor.	Uncharacterized protein.	0.581
AR	NKX3-1	ENSPPAP00000031741	ENSPPAP00000008388	Androgen receptor.	NK3 homeobox 1.	0.732
AR	PTEN	ENSPPAP00000031741	ENSPPAP00000012238	Androgen receptor.	Uncharacterized protein.	0.581
AR	UBE3A	ENSPPAP00000031741	ENSPPAP00000029593	Androgen receptor.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.549
AR	WDR77	ENSPPAP00000031741	ENSPPAP00000031861	Androgen receptor.	WD repeat domain 77.	0.448
BMP4	CTNNB1	ENSPPAP00000011018	ENSPPAP00000024694	TGF_BETA_2 domain-containing protein.	Catenin beta 1.	0.597
BMP4	FGF10	ENSPPAP00000011018	ENSPPAP00000032835	TGF_BETA_2 domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.742
BMP4	FGFR2	ENSPPAP00000011018	ENSPPAP00000023314	TGF_BETA_2 domain-containing protein.	Fibroblast growth factor receptor.	0.539
BMP4	GLI1	ENSPPAP00000011018	ENSPPAP00000041047	TGF_BETA_2 domain-containing protein.	GLI family zinc finger 1.	0.466
BMP4	NOG	ENSPPAP00000011018	ENSPPAP00000001857	TGF_BETA_2 domain-containing protein.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.998