(26 nodes) Granulocyte differentiation network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FASN	Fatty acid synthase. (2511 aa)
	CEBPE	CCAAT/enhancer-binding protein. (284 aa)
	IL17C	Interleukin 17C. (197 aa)
	CEBPA	BZIP domain-containing protein. (141 aa)
	LBR	Lamin B receptor. (615 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	CSF3	Colony stimulating factor 3. (204 aa)
	IL25	Interleukin 25. (177 aa)
	GATA2	GATA binding protein 2. (480 aa)
	SP3	Sp3 transcription factor. (721 aa)
	BAP1	Ubiquitin carboxyl-terminal hydrolase. (729 aa)
	NKAP	NFKB activating protein. (415 aa)
	TAL1	TAL bHLH transcription factor 1, erythroid differentiation factor. (291 aa)
	CBFA2T3	CBFA2/RUNX1 partner transcriptional co-repressor 3. (653 aa)
	GATA1	GATA binding protein 1. (413 aa)
	ZFPM1	Uncharacterized protein. (151 aa)
	ENSPPAP00000026779	Uncharacterized protein. (720 aa)
	SPI1	Spi-1 proto-oncogene. (271 aa)
	JAGN1	Jagunal homolog 1. (183 aa)
	AP3B1	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
	ZBTB46	Zinc finger and BTB domain containing 46. (589 aa)
	CSF2	Colony stimulating factor 2. (144 aa)
	L3MBTL3	L3MBTL histone methyl-lysine binding protein 3. (780 aa)
	LEF1	Lymphoid enhancer binding factor 1. (399 aa)
	DHRS7B	Dehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa)
	CITED2	Uncharacterized protein. (179 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP3B1	LBR	ENSPPAP00000032203	ENSPPAP00000013498	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	Lamin B receptor.	0.549
BAP1	CSF3	ENSPPAP00000010779	ENSPPAP00000005198	Ubiquitin carboxyl-terminal hydrolase.	Colony stimulating factor 3.	0.766
CBFA2T3	FASN	ENSPPAP00000020452	ENSPPAP00000040833	CBFA2/RUNX1 partner transcriptional co-repressor 3.	Fatty acid synthase.	0.424
CBFA2T3	GATA1	ENSPPAP00000020452	ENSPPAP00000023388	CBFA2/RUNX1 partner transcriptional co-repressor 3.	GATA binding protein 1.	0.735
CBFA2T3	GATA2	ENSPPAP00000020452	ENSPPAP00000009054	CBFA2/RUNX1 partner transcriptional co-repressor 3.	GATA binding protein 2.	0.426
CBFA2T3	SPI1	ENSPPAP00000020452	ENSPPAP00000027481	CBFA2/RUNX1 partner transcriptional co-repressor 3.	Spi-1 proto-oncogene.	0.584
CBFA2T3	TAL1	ENSPPAP00000020452	ENSPPAP00000019944	CBFA2/RUNX1 partner transcriptional co-repressor 3.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.820
CEBPA	CEBPE	ENSPPAP00000003416	ENSPPAP00000000252	BZIP domain-containing protein.	CCAAT/enhancer-binding protein.	0.695
CEBPA	CSF3	ENSPPAP00000003416	ENSPPAP00000005198	BZIP domain-containing protein.	Colony stimulating factor 3.	0.504
CEBPA	FASN	ENSPPAP00000003416	ENSPPAP00000040833	BZIP domain-containing protein.	Fatty acid synthase.	0.465
CEBPA	GATA1	ENSPPAP00000003416	ENSPPAP00000023388	BZIP domain-containing protein.	GATA binding protein 1.	0.661
CEBPA	GATA2	ENSPPAP00000003416	ENSPPAP00000009054	BZIP domain-containing protein.	GATA binding protein 2.	0.771
CEBPA	LEF1	ENSPPAP00000003416	ENSPPAP00000040542	BZIP domain-containing protein.	Lymphoid enhancer binding factor 1.	0.681
CEBPA	SPI1	ENSPPAP00000003416	ENSPPAP00000027481	BZIP domain-containing protein.	Spi-1 proto-oncogene.	0.863
CEBPA	TAL1	ENSPPAP00000003416	ENSPPAP00000019944	BZIP domain-containing protein.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.626
CEBPE	CEBPA	ENSPPAP00000000252	ENSPPAP00000003416	CCAAT/enhancer-binding protein.	BZIP domain-containing protein.	0.695
CEBPE	GATA1	ENSPPAP00000000252	ENSPPAP00000023388	CCAAT/enhancer-binding protein.	GATA binding protein 1.	0.604
CEBPE	GATA2	ENSPPAP00000000252	ENSPPAP00000009054	CCAAT/enhancer-binding protein.	GATA binding protein 2.	0.402
CEBPE	SPI1	ENSPPAP00000000252	ENSPPAP00000027481	CCAAT/enhancer-binding protein.	Spi-1 proto-oncogene.	0.730
CSF2	CSF3	ENSPPAP00000036895	ENSPPAP00000005198	Colony stimulating factor 2.	Colony stimulating factor 3.	0.966