STRINGSTRING
SFRP4 SFRP4 PTCH1 PTCH1 PAX6 PAX6 FOXN1 FOXN1 BTG1 BTG1 BAD BAD BMP6 BMP6 COMMD5 COMMD5 PAX2 PAX2 ZBED2 ZBED2 GDF2 GDF2 GDNF GDNF LIF LIF SFN SFN VEZF1 VEZF1 ATOH1 ATOH1 ETV4 ETV4 LOC100979750 LOC100979750 MACROH2A2 MACROH2A2 CD24 CD24 BMP4 BMP4 IL20 IL20 MACROH2A1 MACROH2A1 KDF1 KDF1 MESP1 MESP1 BMP2 BMP2 NUMA1 NUMA1 SERPINE1 SERPINE1 PTCH2 PTCH2 CYP27B1 CYP27B1 PAX8 PAX8 AHI1 AHI1 OVOL2 OVOL2 LOC103783387 LOC103783387 BMP7 BMP7 PROM1 PROM1 NCOA3 NCOA3 PAX4 PAX4 PLAAT4 PLAAT4 CTNNB1 CTNNB1 WNT10B WNT10B ACVRL1 ACVRL1 FOXJ1 FOXJ1 TP73 TP73 CDKN2B CDKN2B VDR VDR SULT2B1 SULT2B1 ETV2 ETV2 ATOH8 ATOH8 NKX2-2 NKX2-2 NOTCH1 NOTCH1 RFX3 RFX3 NKX6-1 NKX6-1 ALOX15B ALOX15B MED1 MED1 LHX1 LHX1 FGF2 FGF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFRP4Secreted frizzled related protein 4. (368 aa)
PTCH1Patched 1. (1446 aa)
PAX6Uncharacterized protein. (467 aa)
FOXN1Forkhead box N1. (648 aa)
BTG1BTG anti-proliferation factor 1. (170 aa)
BADBCL2 associated agonist of cell death. (168 aa)
BMP6Bone morphogenetic protein 6. (453 aa)
COMMD5COMM domain containing 5. (224 aa)
PAX2Paired box 2. (417 aa)
ZBED2Zinc finger BED-type containing 2. (218 aa)
GDF2Growth differentiation factor 2. (429 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
VEZF1Vascular endothelial zinc finger 1. (520 aa)
ATOH1Atonal bHLH transcription factor 1. (356 aa)
ETV4ETS variant 4. (432 aa)
LOC100979750Uncharacterized protein. (444 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
CD24CD24 molecule. (129 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
IL20Interleukin 20. (176 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2115 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (324 aa)
PTCH2Patched 2. (1203 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
PAX8Paired box 8. (456 aa)
AHI1Abelson helper integration site 1. (1240 aa)
OVOL2Ovo like zinc finger 2. (225 aa)
LOC103783387COMM domain-containing protein. (229 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PROM1Prominin 1. (865 aa)
NCOA3Nuclear receptor coactivator. (1423 aa)
PAX4Paired box 4. (351 aa)
PLAAT4Phospholipase A and acyltransferase 4. (164 aa)
CTNNB1Catenin beta 1. (781 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
FOXJ1Forkhead box J1. (405 aa)
TP73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (605 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
VDRVitamin D receptor. (477 aa)
SULT2B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (365 aa)
ETV2ETS variant 2. (342 aa)
ATOH8Atonal bHLH transcription factor 8. (320 aa)
NKX2-2NK2 homeobox 2. (273 aa)
NOTCH1Notch receptor 1. (2573 aa)
RFX3Regulatory factor X3. (765 aa)
NKX6-1Homeobox domain-containing protein. (310 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (676 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1555 aa)
LHX1LIM homeobox 1. (406 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (260 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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