(61 nodes) Regulation of B cell proliferation network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (223 aa)
	SLC39A10	Solute carrier family 39 member 10. (831 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	PAWR	Pro-apoptotic WT1 regulator. (320 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	MNDA	Myeloid cell nuclear differentiation antigen. (407 aa)
	EPHB2	EPH receptor B2. (1039 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1261 aa)
	BST1	Bone marrow stromal cell antigen 1. (332 aa)
	CARD11	Caspase recruitment domain family member 11. (1154 aa)
	CLCF1	Uncharacterized protein. (322 aa)
	CD38	CD38 molecule. (300 aa)
	SASH3	SAM and SH3 domain containing 3. (380 aa)
	TNFRSF13C	Uncharacterized protein. (112 aa)
	CD74	CD74 molecule. (296 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	LOC100984838	Uncharacterized protein. (334 aa)
	CDKN2A	Uncharacterized protein. (173 aa)
	BTK	Tyrosine-protein kinase. (693 aa)
	NCKAP1L	NCK associated protein 1 like. (1127 aa)
	TYROBP	TYRO protein tyrosine kinase binding protein. (113 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1134 aa)
	PKN1	Protein kinase N1. (948 aa)
	MEF2C	Myocyte enhancer factor 2C. (482 aa)
	LOC100995377	Uncharacterized protein. (557 aa)
	CD40	CD40 molecule. (277 aa)
	MIF	Macrophage migration inhibitory factor. (115 aa)
	BCL2	BCL2 apoptosis regulator. (193 aa)
	CHRNB2	Cholinergic receptor nicotinic beta 2 subunit. (502 aa)
	CD320	CD320 molecule. (282 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1189 aa)
	LYN	Tyrosine-protein kinase. (526 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
	ATAD5	ATPase family AAA domain containing 5. (1832 aa)
	TNFRSF21	TNF receptor superfamily member 21. (655 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	PTEN	Uncharacterized protein. (542 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	TNFRSF4	TNF receptor superfamily member 4. (254 aa)
	FCRL3	Fc receptor like 3. (742 aa)
	ENSPPAP00000010058	Uncharacterized protein. (165 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	TNFRSF13B	TNF receptor superfamily member 13B. (293 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (917 aa)
	ADA	Adenosine deaminase. (412 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (285 aa)
	IKZF3	IKAROS family zinc finger 3. (509 aa)
	TFRC	Transferrin receptor. (773 aa)
	MZB1	Marginal zone B and B1 cell specific protein. (189 aa)
	BLK	Tyrosine-protein kinase. (505 aa)
	TICAM1	RHIM domain-containing protein. (541 aa)
	IL7	Interleukin 7. (179 aa)
	IL10	Interleukin 10. (178 aa)
	TIRAP	TIR domain-containing protein. (226 aa)
	TCF3	Transcription factor 3. (673 aa)
	CD300A	CD300a molecule. (299 aa)
	NFATC2	Nuclear factor of activated T cells 2. (912 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	IL2	ENSPPAP00000006331	ENSPPAP00000014571	Adenosine deaminase.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.525
ADA	PTPRC	ENSPPAP00000006331	ENSPPAP00000022461	Adenosine deaminase.	Protein tyrosine phosphatase receptor type C.	0.428
ATAD5	ATM	ENSPPAP00000014562	ENSPPAP00000009058	ATPase family AAA domain containing 5.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.570
ATM	ATAD5	ENSPPAP00000009058	ENSPPAP00000014562	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATPase family AAA domain containing 5.	0.570
ATM	BCL2	ENSPPAP00000009058	ENSPPAP00000017780	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.536
ATM	BTK	ENSPPAP00000009058	ENSPPAP00000031524	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.588
ATM	CASP3	ENSPPAP00000009058	ENSPPAP00000013228	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Caspase 3; Belongs to the peptidase C14A family.	0.536
ATM	CDKN1A	ENSPPAP00000009058	ENSPPAP00000029279	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase inhibitor 1A.	0.680
ATM	LOC100995377	ENSPPAP00000009058	ENSPPAP00000033339	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.583
ATM	PTEN	ENSPPAP00000009058	ENSPPAP00000012238	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.583
BCL2	ATM	ENSPPAP00000017780	ENSPPAP00000009058	BCL2 apoptosis regulator.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.536
BCL2	BCL6	ENSPPAP00000017780	ENSPPAP00000011560	BCL2 apoptosis regulator.	BCL6 transcription repressor.	0.750
BCL2	BTK	ENSPPAP00000017780	ENSPPAP00000031524	BCL2 apoptosis regulator.	Tyrosine-protein kinase.	0.490
BCL2	CASP3	ENSPPAP00000017780	ENSPPAP00000013228	BCL2 apoptosis regulator.	Caspase 3; Belongs to the peptidase C14A family.	0.882
BCL2	CD38	ENSPPAP00000017780	ENSPPAP00000026576	BCL2 apoptosis regulator.	CD38 molecule.	0.610
BCL2	CD40	ENSPPAP00000017780	ENSPPAP00000033584	BCL2 apoptosis regulator.	CD40 molecule.	0.467
BCL2	CDKN1A	ENSPPAP00000017780	ENSPPAP00000029279	BCL2 apoptosis regulator.	Cyclin dependent kinase inhibitor 1A.	0.647
BCL2	CTLA4	ENSPPAP00000017780	ENSPPAP00000037872	BCL2 apoptosis regulator.	Cytotoxic T-lymphocyte associated protein 4.	0.440
BCL2	IL10	ENSPPAP00000017780	ENSPPAP00000001878	BCL2 apoptosis regulator.	Interleukin 10.	0.539
BCL2	IL2	ENSPPAP00000017780	ENSPPAP00000014571	BCL2 apoptosis regulator.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.633