(69 nodes) Pancreas development network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	BMP6	Bone morphogenetic protein 6. (453 aa)
	RFX6	Regulatory factor X6. (928 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (624 aa)
	ILDR2	Immunoglobulin like domain containing receptor 2. (620 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
	PCSK1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (474 aa)
	BHLHA15	Basic helix-loop-helix family member a15. (171 aa)
	WFS1	Wolframin ER transmembrane glycoprotein. (890 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
	NR5A2	Nuclear receptor subfamily 5 group A member 2. (541 aa)
	NKX2-2	NK2 homeobox 2. (273 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	NKX3-2	NK3 homeobox 2. (291 aa)
	RFX3	Regulatory factor X3. (765 aa)
	NKX6-1	Homeobox domain-containing protein. (310 aa)
	HNF1B	HNF1 homeobox B. (567 aa)
	SOX4	HMG box domain-containing protein. (251 aa)
	ACVR2B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
	PAX6	Uncharacterized protein. (467 aa)
	GDF11	Growth differentiation factor 11. (398 aa)
	CELA1	Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (258 aa)
	ONECUT1	One cut domain family member. (402 aa)
	IGF2	Insulin like growth factor 2. (236 aa)
	IL6	Uncharacterized protein. (198 aa)
	FOXF1	Forkhead box F1. (321 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	ONECUT2	One cut domain family member. (449 aa)
	CDK6	Protein kinase domain-containing protein. (84 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (402 aa)
	ALDH1A2	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (414 aa)
	PAX4	Paired box 4. (351 aa)
	WLS	Wnt ligand secretion mediator. (541 aa)
	PDX1	Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (263 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (771 aa)
	FOXA2	Fork-head domain-containing protein. (337 aa)
	ANXA1	Annexin. (346 aa)
	GIPR	Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (450 aa)
	TCF7L2	Transcription factor 7 like 2. (555 aa)
	ENSPPAP00000013852	RRM domain-containing protein. (161 aa)
	ZIC3	Zic family member 3. (466 aa)
	SIDT2	SID1 transmembrane family member 2. (830 aa)
	GIP	Uncharacterized protein. (94 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	NKX6-2	Homeobox domain-containing protein. (230 aa)
	IL6R	Interleukin 6 receptor. (468 aa)
	SELENOT	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (189 aa)
	MSLN	Mesothelin. (622 aa)
	ENSPPAP00000011278	Protein kinase domain-containing protein. (351 aa)
	BMP4	TGF_BETA_2 domain-containing protein. (402 aa)
	INSR	Tyrosine-protein kinase receptor. (1362 aa)
	CCDC40	Coiled-coil domain containing 40. (1142 aa)
	CCDC39	Coiled-coil domain containing 39. (941 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
	ENSPPAP00000007855	Uncharacterized protein. (192 aa)
	MEN1	Menin 1. (615 aa)
	MEIS2	Meis homeobox 2. (477 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (616 aa)
	HNF1A	HNF1 homeobox A. (662 aa)
	MNX1	Homeobox domain-containing protein. (149 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	GATA6	Uncharacterized protein. (402 aa)
	NEUROG3	Neurogenin 3. (214 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR2B	BMP4	ENSPPAP00000040964	ENSPPAP00000011018	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF_BETA_2 domain-containing protein.	0.989
ACVR2B	BMP5	ENSPPAP00000040964	ENSPPAP00000001212	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 5.	0.975
ACVR2B	BMP6	ENSPPAP00000040964	ENSPPAP00000000559	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 6.	0.985
ACVR2B	GDF11	ENSPPAP00000040964	ENSPPAP00000027230	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Growth differentiation factor 11.	0.998
ACVR2B	SMAD2	ENSPPAP00000040964	ENSPPAP00000024577	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.974
ACVR2B	ZIC3	ENSPPAP00000040964	ENSPPAP00000013687	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Zic family member 3.	0.706
ANXA1	CTNNB1	ENSPPAP00000014806	ENSPPAP00000024694	Annexin.	Catenin beta 1.	0.488
ANXA1	WNT5A	ENSPPAP00000014806	ENSPPAP00000008134	Annexin.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.419
BMP4	ACVR2B	ENSPPAP00000011018	ENSPPAP00000040964	TGF_BETA_2 domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.989
BMP4	BMP5	ENSPPAP00000011018	ENSPPAP00000001212	TGF_BETA_2 domain-containing protein.	Bone morphogenetic protein 5.	0.685
BMP4	BMP6	ENSPPAP00000011018	ENSPPAP00000000559	TGF_BETA_2 domain-containing protein.	Bone morphogenetic protein 6.	0.970
BMP4	CTNNB1	ENSPPAP00000011018	ENSPPAP00000024694	TGF_BETA_2 domain-containing protein.	Catenin beta 1.	0.597
BMP4	FGF10	ENSPPAP00000011018	ENSPPAP00000032835	TGF_BETA_2 domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.742
BMP4	FOXA2	ENSPPAP00000011018	ENSPPAP00000016488	TGF_BETA_2 domain-containing protein.	Fork-head domain-containing protein.	0.465
BMP4	FOXF1	ENSPPAP00000011018	ENSPPAP00000024778	TGF_BETA_2 domain-containing protein.	Forkhead box F1.	0.731
BMP4	GATA6	ENSPPAP00000011018	ENSPPAP00000003349	TGF_BETA_2 domain-containing protein.	Uncharacterized protein.	0.549
BMP4	HNF4A	ENSPPAP00000011018	ENSPPAP00000029913	TGF_BETA_2 domain-containing protein.	Hepatocyte nuclear factor 4 alpha.	0.400
BMP4	IGF2	ENSPPAP00000011018	ENSPPAP00000025443	TGF_BETA_2 domain-containing protein.	Insulin like growth factor 2.	0.401
BMP4	IHH	ENSPPAP00000011018	ENSPPAP00000021798	TGF_BETA_2 domain-containing protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.504
BMP4	IL6	ENSPPAP00000011018	ENSPPAP00000025189	TGF_BETA_2 domain-containing protein.	Uncharacterized protein.	0.547