(51 nodes) Heterochromatin assembly network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
	HELLS	Helicase, lymphoid specific. (884 aa)
	KMT2D	Lysine methyltransferase 2D. (4780 aa)
	RB1	RB transcriptional corepressor 1. (911 aa)
	BAZ2A	Bromodomain adjacent to zinc finger domain 2A. (1906 aa)
	CENPVL3	Centromere protein V like 3. (287 aa)
	NDN	MAGE domain-containing protein. (261 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa)
	MBD3L1	Methyl-CpG binding domain protein 3 like 1. (193 aa)
	ENSPPAP00000004842	Chromo domain-containing protein. (101 aa)
	RIF1	Replication timing regulatory factor 1. (2473 aa)
	H1-0	H1 histone family member 0. (194 aa)
	TNP1	Transition protein 1. (55 aa)
	SIRT1	Sirtuin 1. (693 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1637 aa)
	CTCF	CCCTC-binding factor. (727 aa)
	HAT1	Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (146 aa)
	SCMH1	Scm polycomb group protein homolog 1. (660 aa)
	ENSPPAP00000039182	Uncharacterized protein. (204 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (583 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (456 aa)
	NRM	Nurim. (262 aa)
	CBX3	Uncharacterized protein. (183 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (735 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (586 aa)
	BEND3	BEN domain containing 3. (827 aa)
	ZDBF2	Zinc finger DBF-type containing 2. (2354 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (664 aa)
	DNMT3A	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
	BAHD1	Bromo adjacent homology domain containing 1. (779 aa)
	CENPV	GFA domain-containing protein. (156 aa)
	SMCHD1	Structural maintenance of chromosomes flexible hinge domain containing 1. (2005 aa)
	ENSPPAP00000027667	Uncharacterized protein. (98 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
	SUV39H1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
	MBD2	MBD domain-containing protein. (365 aa)
	FAM172A	Family with sequence similarity 172 member A. (379 aa)
	AXIN1	Axin 1. (862 aa)
	MBD3	Methyl-CpG binding domain protein 3. (272 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1108 aa)
	SPTY2D1	SPT2 chromatin protein domain containing 1. (685 aa)
	ZNFX1	Zinc finger NFX1-type containing 1. (1918 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (430 aa)
	GNAS-2	Uncharacterized protein. (245 aa)
	DOT1L	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1637 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (493 aa)
	SIRT6	Sirtuin 6. (355 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAHD1	EZH2	ENSPPAP00000029730	ENSPPAP00000016828	Bromo adjacent homology domain containing 1.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.414
BAHD1	HDAC1	ENSPPAP00000029730	ENSPPAP00000018577	Bromo adjacent homology domain containing 1.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.718
BAHD1	HDAC5	ENSPPAP00000029730	ENSPPAP00000017851	Bromo adjacent homology domain containing 1.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.574
BAHD1	SMARCA5	ENSPPAP00000029730	ENSPPAP00000010646	Bromo adjacent homology domain containing 1.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5.	0.408
BAHD1	SUV39H1	ENSPPAP00000029730	ENSPPAP00000013766	Bromo adjacent homology domain containing 1.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.432
BAZ2A	DNMT1	ENSPPAP00000000986	ENSPPAP00000008604	Bromodomain adjacent to zinc finger domain 2A.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.653
BAZ2A	HDAC1	ENSPPAP00000000986	ENSPPAP00000018577	Bromodomain adjacent to zinc finger domain 2A.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.791
BAZ2A	HELLS	ENSPPAP00000000986	ENSPPAP00000000540	Bromodomain adjacent to zinc finger domain 2A.	Helicase, lymphoid specific.	0.677
BAZ2A	POLE3	ENSPPAP00000000986	ENSPPAP00000039916	Bromodomain adjacent to zinc finger domain 2A.	DNA polymerase epsilon 3, accessory subunit.	0.655
BAZ2A	SMARCA5	ENSPPAP00000000986	ENSPPAP00000010646	Bromodomain adjacent to zinc finger domain 2A.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5.	0.995
BAZ2A	SUV39H1	ENSPPAP00000000986	ENSPPAP00000013766	Bromodomain adjacent to zinc finger domain 2A.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.418
CBX3	CTCF	ENSPPAP00000035135	ENSPPAP00000041797	Uncharacterized protein.	CCCTC-binding factor.	0.510
CBX3	DNMT1	ENSPPAP00000035135	ENSPPAP00000008604	Uncharacterized protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.617
CBX3	EZH2	ENSPPAP00000035135	ENSPPAP00000016828	Uncharacterized protein.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.526
CBX3	HDAC1	ENSPPAP00000035135	ENSPPAP00000018577	Uncharacterized protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.702
CBX3	MECP2	ENSPPAP00000035135	ENSPPAP00000021674	Uncharacterized protein.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.532
CBX3	SMCHD1	ENSPPAP00000035135	ENSPPAP00000028803	Uncharacterized protein.	Structural maintenance of chromosomes flexible hinge domain containing 1.	0.410
CBX3	SUV39H1	ENSPPAP00000035135	ENSPPAP00000013766	Uncharacterized protein.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.839
CTBP1	HDAC1	ENSPPAP00000019471	ENSPPAP00000018577	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.996
CTBP1	SIRT1	ENSPPAP00000019471	ENSPPAP00000007254	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Sirtuin 1.	0.485