STRINGSTRING
KLHL22 KLHL22 PIP4P1 PIP4P1 GPR137C GPR137C PIK3CA PIK3CA RRAGA RRAGA ENSPPAP00000002927 ENSPPAP00000002927 SMCR8 SMCR8 MIOS MIOS RHEB RHEB LARS1 LARS1 HTR6 HTR6 XBP1 XBP1 SEH1L SEH1L FLCN FLCN LAMTOR5 LAMTOR5 OTUD5 OTUD5 SEC13 SEC13 RPTOR RPTOR TREM2 TREM2 LAMTOR1 LAMTOR1 FNIP1 FNIP1 WAC WAC CLEC16A CLEC16A USP9X USP9X RICTOR RICTOR ENSPPAP00000033668 ENSPPAP00000033668 GPR137 GPR137 NCKAP1L NCKAP1L LIN28A LIN28A LAMTOR4 LAMTOR4 LAMTOR2 LAMTOR2 HDAC3 HDAC3 CTNS CTNS SIK3 SIK3 LEP LEP AKT3 AKT3 PIH1D1 PIH1D1 RELN RELN RRAGB RRAGB LAMTOR3 LAMTOR3 ENSPPAP00000022320 ENSPPAP00000022320 MLST8 MLST8 WDR59 WDR59 SLC38A9 SLC38A9 LOC100974009 LOC100974009 TELO2 TELO2 GPR137B GPR137B GOLPH3 GOLPH3 GAS6 GAS6 WDR24 WDR24 RRAGC RRAGC RRAGD RRAGD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLHL22Kelch like family member 22. (634 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
GPR137CG protein-coupled receptor 137C. (348 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
RRAGARas related GTP binding A. (313 aa)
ENSPPAP00000002927CCHC-type domain-containing protein. (202 aa)
SMCR8SMCR8-C9orf72 complex subunit. (937 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
RHEBUncharacterized protein. (173 aa)
LARS1Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1177 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
XBP1BZIP domain-containing protein. (380 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (360 aa)
FLCNFolliculin. (579 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (173 aa)
OTUD5OTU domain-containing protein. (349 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
FNIP1Folliculin interacting protein 1. (1166 aa)
WACWW domain containing adaptor with coiled-coil. (618 aa)
CLEC16AC-type lectin domain containing 16A. (1053 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2576 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1686 aa)
ENSPPAP00000033668Uncharacterized protein. (85 aa)
GPR137G protein-coupled receptor 137. (475 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
LIN28ALin-28 homolog A. (209 aa)
LAMTOR4Uncharacterized protein. (137 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
CTNSCystinosin, lysosomal cystine transporter. (400 aa)
SIK3SIK family kinase 3. (1300 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIH1D1PIH1 domain containing 1. (321 aa)
RELNReelin. (3460 aa)
RRAGBRas related GTP binding B. (374 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
ENSPPAP00000022320Uncharacterized protein. (203 aa)
MLST8MTOR associated protein, LST8 homolog. (327 aa)
WDR59WD repeat domain 59. (974 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
LOC100974009Uncharacterized protein. (184 aa)
TELO2Telomere maintenance 2. (837 aa)
GPR137BG protein-coupled receptor 137B. (395 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
GAS6Growth arrest specific 6. (679 aa)
WDR24WD repeat domain 24. (920 aa)
RRAGCRas related GTP binding C. (399 aa)
RRAGDRas related GTP binding D. (400 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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