STRINGSTRING
DOCK7 DOCK7 HCLS1 HCLS1 ARAF ARAF TBK1 TBK1 LIF LIF IFNA8 IFNA8 IFNE IFNE APP APP IFNA10 IFNA10 IFNA5 IFNA5 LOC100972005 LOC100972005 ERCC6 ERCC6 IFNA6 IFNA6 IFNA14 IFNA14 IFNA17 IFNA17 UCN UCN ARRB2 ARRB2 TNKS1BP1 TNKS1BP1 MAPKAP1 MAPKAP1 ENSPPAP00000031956 ENSPPAP00000031956 SH2D3A SH2D3A NTRK2 NTRK2 SMYD3 SMYD3 PRKD2 PRKD2 CNOT9 CNOT9 PRKD1 PRKD1 CAV1 CAV1 GSK3A GSK3A ENSPPAP00000026998 ENSPPAP00000026998 ANGPT1 ANGPT1 LATS1 LATS1 BRAF BRAF AKAP9 AKAP9 IL6 IL6 MAD2L2 MAD2L2 TCL1B TCL1B SPRY2 SPRY2 RAF1 RAF1 STOX1 STOX1 ENSPPAP00000023305 ENSPPAP00000023305 CAMK1 CAMK1 RET RET IAPP IAPP WNT3A WNT3A HDAC6 HDAC6 IFNA21 IFNA21 HSP90AB1 HSP90AB1 TXN TXN NTRK3 NTRK3 PAK1 PAK1 EIF4G1 EIF4G1 PTGS2 PTGS2 RAPGEF3 RAPGEF3 NGF NGF TERF2IP TERF2IP NTF3 NTF3 CD44 CD44 NOS1 NOS1 RIPK2 RIPK2 EGFR EGFR ATP2B4 ATP2B4 TCL1A TCL1A AKT1 AKT1 FNIP1 FNIP1 IL11 IL11 NRXN1 NRXN1 RAMP3 RAMP3 CAPRIN2 CAPRIN2 OPRD1 OPRD1 BAG4 BAG4 IFNG IFNG RPTOR RPTOR IFNA7 IFNA7 PDCD10 PDCD10 MIF MIF BCL2 BCL2 TGFB1 TGFB1 ENSPPAP00000016834 ENSPPAP00000016834 AXIN1 AXIN1 GAS6 GAS6 IRGM IRGM PARK7 PARK7 PINK1 PINK1 FNIP2 FNIP2 MTCP1 MTCP1 BDNF BDNF BCAR3 BCAR3 ENSPPAP00000011862 ENSPPAP00000011862 AVP AVP OSM OSM HAX1 HAX1 PIK3CA PIK3CA ENSPPAP00000009855 ENSPPAP00000009855 ENSPPAP00000009209 ENSPPAP00000009209 STK4 STK4 WNT5A WNT5A CREBL2 CREBL2 SH2D3C SH2D3C CALCR CALCR SNCA SNCA IFNW1 IFNW1 NTF4 NTF4 CSF3 CSF3 TFRC TFRC GCG GCG TENM1 TENM1 TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2109 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (484 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
TBK1TANK binding kinase 1. (729 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
IFNA8Interferon alpha 8. (189 aa)
IFNEInterferon epsilon. (208 aa)
APPAmyloid beta precursor protein. (770 aa)
IFNA10Interferon alpha 10. (189 aa)
IFNA5Interferon alpha 5. (189 aa)
LOC100972005Uncharacterized protein. (198 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1491 aa)
IFNA6Interferon alpha 6. (189 aa)
IFNA14Interferon alpha 14. (189 aa)
IFNA17Interferon alpha 17. (189 aa)
UCNUrocortin. (124 aa)
ARRB2Arrestin beta 2. (447 aa)
TNKS1BP1Tankyrase 1 binding protein 1. (1727 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
ENSPPAP00000031956HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (254 aa)
SH2D3ASH2 domain containing 3A. (576 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
SMYD3SET and MYND domain containing 3. (428 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (826 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (331 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (463 aa)
ENSPPAP00000026998Uncharacterized protein. (493 aa)
ANGPT1Angiopoietin 1. (498 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
AKAP9A-kinase anchoring protein 9. (3880 aa)
IL6Uncharacterized protein. (198 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
TCL1BT cell leukemia/lymphoma 1B. (128 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
STOX1Storkhead box 1. (885 aa)
ENSPPAP00000023305DJ-1_PfpI domain-containing protein. (168 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (380 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
IAPPIslet amyloid polypeptide. (89 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
HDAC6Histone deacetylase 6. (1215 aa)
IFNA21Interferon alpha 21. (189 aa)
HSP90AB1HATPase_c domain-containing protein. (688 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
PAK1Non-specific serine/threonine protein kinase. (532 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1606 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (905 aa)
NGFNGF domain-containing protein; Belongs to the NGF-beta family. (123 aa)
TERF2IPTERF2 interacting protein. (394 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
CD44CD44 molecule (Indian blood group). (742 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1403 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
TCL1AT cell leukemia/lymphoma 1A. (114 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
FNIP1Folliculin interacting protein 1. (1166 aa)
IL11Interleukin 11. (199 aa)
NRXN1Neurexin 1. (1445 aa)
RAMP3Receptor activity modifying protein 3. (151 aa)
CAPRIN2Caprin family member 2. (1094 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
BAG4BCL2 associated athanogene 4. (460 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
IFNA7Interferon alpha 7. (189 aa)
PDCD10Programmed cell death 10. (212 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ENSPPAP00000016834Uncharacterized protein. (195 aa)
AXIN1Axin 1. (862 aa)
GAS6Growth arrest specific 6. (679 aa)
IRGMImmunity related GTPase M. (195 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
PINK1PTEN induced kinase 1. (554 aa)
FNIP2Folliculin interacting protein 2. (1114 aa)
MTCP1Mature T cell proliferation 1. (107 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (826 aa)
ENSPPAP00000011862BAG domain-containing protein. (350 aa)
AVPUncharacterized protein; Belongs to the vasopressin/oxytocin family. (134 aa)
OSMOncostatin M. (252 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
ENSPPAP00000009855Thioredoxin domain-containing protein. (82 aa)
ENSPPAP00000009209Profilin; Belongs to the profilin family. (91 aa)
STK4Serine/threonine kinase 4. (487 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
CREBL2BZIP domain-containing protein. (180 aa)
SH2D3CSH2 domain containing 3C. (860 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
IFNW1Interferon omega 1. (200 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
CSF3Colony stimulating factor 3. (204 aa)
TFRCTransferrin receptor. (773 aa)
GCGGlucagon. (179 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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