(52 nodes) Regulation of cell adhesion mediated by integrin network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	IFT74	Intraflagellar transport 74. (584 aa)
	SWAP70	Switching B cell complex subunit SWAP70. (585 aa)
	PODXL	Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (520 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
	FERMT3	Fermitin family member 3. (669 aa)
	ENSPPAP00000024034	Uncharacterized protein. (541 aa)
	WNK1	WNK lysine deficient protein kinase 1. (2832 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	PLAU	Plasminogen activator, urokinase. (431 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	ENSPPAP00000029143	Uncharacterized protein. (511 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	CXCL13	C-X-C motif chemokine. (109 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	ADAM9	ADAM metallopeptidase domain 9. (819 aa)
	JAM3	Junctional adhesion molecule 3. (310 aa)
	CD3E	CD3e molecule. (207 aa)
	DEF6	DEF6 guanine nucleotide exchange factor. (621 aa)
	PIEZO1	Piezo-type mechanosensitive ion channel component. (2516 aa)
	HRG	Histidine rich glycoprotein. (525 aa)
	ENSPPAP00000009275	Uncharacterized protein. (269 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
	EFNA1	Ephrin A1; Belongs to the ephrin family. (205 aa)
	ENSPPAP00000006969	Uncharacterized protein. (584 aa)
	ADA	Adenosine deaminase. (412 aa)
	FERMT1	Fermitin family member 1. (677 aa)
	LPXN	Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (387 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	LRRC45	Leucine rich repeat containing 45. (670 aa)
	NCKAP1L	NCK associated protein 1 like. (1127 aa)
	MUC1	Mucin 1, cell surface associated. (463 aa)
	SKAP1	Src kinase associated phosphoprotein 1. (359 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	CIB1	Uncharacterized protein. (143 aa)
	TESC	Tescalcin. (214 aa)
	LOC100989599	Uncharacterized protein; Belongs to the cytochrome P450 family. (339 aa)
	CCL5	C-C motif chemokine. (91 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (324 aa)
	LOC100968595	Uncharacterized protein. (860 aa)
	CRK	CRK proto-oncogene, adaptor protein. (304 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (814 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	NEXMIF	Neurite extension and migration factor. (1516 aa)
	LYN	Tyrosine-protein kinase. (526 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	DPP4	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (766 aa)
	EPHA8	EPH receptor A8. (997 aa)
	CCL21	C-C motif chemokine ligand 21. (134 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	EPHA2	EPH receptor A2. (976 aa)
	PDE3B	Phosphodiesterase. (1112 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	DPP4	ENSPPAP00000006331	ENSPPAP00000039801	Adenosine deaminase.	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	0.994
CCL21	CCL5	ENSPPAP00000003129	ENSPPAP00000042652	C-C motif chemokine ligand 21.	C-C motif chemokine.	0.996
CCL21	CXCL13	ENSPPAP00000003129	ENSPPAP00000030059	C-C motif chemokine ligand 21.	C-X-C motif chemokine.	0.908
CCL5	CCL21	ENSPPAP00000042652	ENSPPAP00000003129	C-C motif chemokine.	C-C motif chemokine ligand 21.	0.996
CCL5	CXCL13	ENSPPAP00000042652	ENSPPAP00000030059	C-C motif chemokine.	C-X-C motif chemokine.	0.824
CCL5	LIF	ENSPPAP00000042652	ENSPPAP00000002988	C-C motif chemokine.	LIF interleukin 6 family cytokine.	0.443
CCL5	SERPINE1	ENSPPAP00000042652	ENSPPAP00000042653	C-C motif chemokine.	Serpin family E member 1; Belongs to the serpin family.	0.559
CD3E	LYN	ENSPPAP00000017506	ENSPPAP00000014697	CD3e molecule.	Tyrosine-protein kinase.	0.488
CD3E	PTPN6	ENSPPAP00000017506	ENSPPAP00000009042	CD3e molecule.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.699
CD3E	SKAP1	ENSPPAP00000017506	ENSPPAP00000032839	CD3e molecule.	Src kinase associated phosphoprotein 1.	0.430
CD3E	SYK	ENSPPAP00000017506	ENSPPAP00000029310	CD3e molecule.	Tyrosine-protein kinase.	0.985
CIB1	CRK	ENSPPAP00000041500	ENSPPAP00000013691	Uncharacterized protein.	CRK proto-oncogene, adaptor protein.	0.457
CIB1	PTK2	ENSPPAP00000041500	ENSPPAP00000041016	Uncharacterized protein.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.461
CRK	CIB1	ENSPPAP00000013691	ENSPPAP00000041500	CRK proto-oncogene, adaptor protein.	Uncharacterized protein.	0.457
CRK	CRKL	ENSPPAP00000013691	ENSPPAP00000003951	CRK proto-oncogene, adaptor protein.	CRK like proto-oncogene, adaptor protein.	0.977
CRK	ENSPPAP00000029143	ENSPPAP00000013691	ENSPPAP00000029143	CRK proto-oncogene, adaptor protein.	Uncharacterized protein.	0.422
CRK	EPHA2	ENSPPAP00000013691	ENSPPAP00000002235	CRK proto-oncogene, adaptor protein.	EPH receptor A2.	0.841
CRK	ITGB3	ENSPPAP00000013691	ENSPPAP00000014470	CRK proto-oncogene, adaptor protein.	Integrin beta; Belongs to the integrin beta chain family.	0.834
CRK	LPXN	ENSPPAP00000013691	ENSPPAP00000004444	CRK proto-oncogene, adaptor protein.	Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN).	0.745
CRK	LYN	ENSPPAP00000013691	ENSPPAP00000014697	CRK proto-oncogene, adaptor protein.	Tyrosine-protein kinase.	0.592