(18 nodes) Toll-like receptor 4 signaling pathway network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	CD14	CD14 molecule. (384 aa)
	OAS1	2',5'-oligoadenylate synthetase 1. (401 aa)
	RAB11FIP2	RAB11 family interacting protein 2. (512 aa)
	TRIL	TLR4 interactor with leucine rich repeats. (811 aa)
	SCIMP	SLP adaptor and CSK interacting membrane protein. (144 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (482 aa)
	LY96	MD2 protein. (160 aa)
	PIK3AP1	Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (456 aa)
	TNIP3	TNFAIP3 interacting protein 3. (376 aa)
	TIRAP	TIR domain-containing protein. (226 aa)
	LYN	Tyrosine-protein kinase. (526 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
	NMI	N-myc and STAT interactor. (307 aa)
	S100A14	S100 calcium binding protein A14; Belongs to the S-100 family. (104 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (712 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD14	LY96	ENSPPAP00000037310	ENSPPAP00000010406	CD14 molecule.	MD2 protein.	0.971
CD14	TLR4	ENSPPAP00000037310	ENSPPAP00000016171	CD14 molecule.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.977
CD14	TRIL	ENSPPAP00000037310	ENSPPAP00000006079	CD14 molecule.	TLR4 interactor with leucine rich repeats.	0.401
IRAK1	LY96	ENSPPAP00000034763	ENSPPAP00000010406	Interleukin 1 receptor associated kinase 1.	MD2 protein.	0.823
IRAK1	NFKBIA	ENSPPAP00000034763	ENSPPAP00000038162	Interleukin 1 receptor associated kinase 1.	ANK_REP_REGION domain-containing protein.	0.781
IRAK1	RIPK2	ENSPPAP00000034763	ENSPPAP00000042959	Interleukin 1 receptor associated kinase 1.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.554
IRAK1	TIRAP	ENSPPAP00000034763	ENSPPAP00000001223	Interleukin 1 receptor associated kinase 1.	TIR domain-containing protein.	0.992
IRAK1	TLR4	ENSPPAP00000034763	ENSPPAP00000016171	Interleukin 1 receptor associated kinase 1.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.835
LY96	CD14	ENSPPAP00000010406	ENSPPAP00000037310	MD2 protein.	CD14 molecule.	0.971
LY96	IRAK1	ENSPPAP00000010406	ENSPPAP00000034763	MD2 protein.	Interleukin 1 receptor associated kinase 1.	0.823
LY96	NFKBIA	ENSPPAP00000010406	ENSPPAP00000038162	MD2 protein.	ANK_REP_REGION domain-containing protein.	0.465
LY96	TIRAP	ENSPPAP00000010406	ENSPPAP00000001223	MD2 protein.	TIR domain-containing protein.	0.967
LY96	TLR4	ENSPPAP00000010406	ENSPPAP00000016171	MD2 protein.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.999
LY96	TRIL	ENSPPAP00000010406	ENSPPAP00000006079	MD2 protein.	TLR4 interactor with leucine rich repeats.	0.528
LYN	RIPK2	ENSPPAP00000014697	ENSPPAP00000042959	Tyrosine-protein kinase.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.431
LYN	SCIMP	ENSPPAP00000014697	ENSPPAP00000006725	Tyrosine-protein kinase.	SLP adaptor and CSK interacting membrane protein.	0.438
NFKBIA	IRAK1	ENSPPAP00000038162	ENSPPAP00000034763	ANK_REP_REGION domain-containing protein.	Interleukin 1 receptor associated kinase 1.	0.781
NFKBIA	LY96	ENSPPAP00000038162	ENSPPAP00000010406	ANK_REP_REGION domain-containing protein.	MD2 protein.	0.465
NFKBIA	RIPK2	ENSPPAP00000038162	ENSPPAP00000042959	ANK_REP_REGION domain-containing protein.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.462
NFKBIA	TLR4	ENSPPAP00000038162	ENSPPAP00000016171	ANK_REP_REGION domain-containing protein.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.591