(10 nodes) Toll-like receptor 9 signaling pathway network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100986336	TIR domain-containing protein. (1033 aa)
	EPG5	Ectopic P-granules autophagy protein 5 homolog. (2581 aa)
	UNC93B1	Unc-93 homolog B1, TLR signaling regulator. (561 aa)
	TNIP2	CCHC NOA-type domain-containing protein. (322 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (712 aa)
	ENSPPAP00000035541	CCHC NOA-type domain-containing protein. (372 aa)
	HAVCR2	Hepatitis A virus cellular receptor 2. (301 aa)
	PIK3AP1	Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (482 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (460 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IRAK1	IRAK4	ENSPPAP00000034763	ENSPPAP00000009286	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 4.	0.999
IRAK1	LOC100986336	ENSPPAP00000034763	ENSPPAP00000004282	Interleukin 1 receptor associated kinase 1.	TIR domain-containing protein.	0.853
IRAK4	IRAK1	ENSPPAP00000009286	ENSPPAP00000034763	Interleukin 1 receptor associated kinase 4.	Interleukin 1 receptor associated kinase 1.	0.999
IRAK4	LOC100986336	ENSPPAP00000009286	ENSPPAP00000004282	Interleukin 1 receptor associated kinase 4.	TIR domain-containing protein.	0.835
IRAK4	UNC93B1	ENSPPAP00000009286	ENSPPAP00000017214	Interleukin 1 receptor associated kinase 4.	Unc-93 homolog B1, TLR signaling regulator.	0.466
LOC100986336	IRAK1	ENSPPAP00000004282	ENSPPAP00000034763	TIR domain-containing protein.	Interleukin 1 receptor associated kinase 1.	0.853
LOC100986336	IRAK4	ENSPPAP00000004282	ENSPPAP00000009286	TIR domain-containing protein.	Interleukin 1 receptor associated kinase 4.	0.835
LOC100986336	UNC93B1	ENSPPAP00000004282	ENSPPAP00000017214	TIR domain-containing protein.	Unc-93 homolog B1, TLR signaling regulator.	0.887
UNC93B1	IRAK4	ENSPPAP00000017214	ENSPPAP00000009286	Unc-93 homolog B1, TLR signaling regulator.	Interleukin 1 receptor associated kinase 4.	0.466
UNC93B1	LOC100986336	ENSPPAP00000017214	ENSPPAP00000004282	Unc-93 homolog B1, TLR signaling regulator.	TIR domain-containing protein.	0.887