STRINGSTRING
EIF2AK4 EIF2AK4 RNF152 RNF152 IMPACT IMPACT WDR59 WDR59 ENSPPAP00000016425 ENSPPAP00000016425 WDR24 WDR24 RRAGC RRAGC ATF4 ATF4 EIF2AK3 EIF2AK3 RNF167 RNF167 TFEB TFEB MAPK3 MAPK3 NPRL3 NPRL3 BECN1 BECN1 CDKN1A CDKN1A SH3GLB1 SH3GLB1 MAP1LC3A MAP1LC3A PRKD1 PRKD1 SESN2 SESN2 ITFG2 ITFG2 MTOR MTOR FAS FAS SZT2 SZT2 EIF2AK2 EIF2AK2 EIF2S1 EIF2S1 SESN1 SESN1 DAP DAP MAPK10 MAPK10 FLCN FLCN MAP3K5 MAP3K5 ATF3 ATF3 RRAGD RRAGD LOC100983911 LOC100983911 LARS1 LARS1 ATF2 ATF2 SESN3 SESN3 GCN1 GCN1 MIOS MIOS MAPK1 MAPK1 LOC100980724 LOC100980724 RRAGA RRAGA C12orf66 C12orf66 ENSPPAP00000002562 ENSPPAP00000002562 KPTN KPTN NPRL2 NPRL2 SEH1L SEH1L UCP2 UCP2 MAPK8 MAPK8 RRAGB RRAGB BMT2 BMT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1734 aa)
RNF152Ring finger protein 152. (203 aa)
IMPACTImpact RWD domain protein. (310 aa)
WDR59WD repeat domain 59. (974 aa)
ENSPPAP00000016425zf-C3HC4 domain-containing protein. (204 aa)
WDR24WD repeat domain 24. (920 aa)
RRAGCRas related GTP binding C. (399 aa)
ATF4Activating transcription factor 4. (340 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
RNF167Ring finger protein 167. (351 aa)
TFEBTranscription factor EB. (552 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (311 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (568 aa)
BECN1Beclin 1. (450 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (394 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (125 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
SESN2Sestrin 2. (480 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (447 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
FASFas cell surface death receptor. (335 aa)
SZT2SZT2 subunit of KICSTOR complex. (3431 aa)
EIF2AK2Eukaryotic translation initiation factor 2-alpha kinase 2. (552 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
SESN1Sestrin 1. (551 aa)
DAPDeath associated protein. (204 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
FLCNFolliculin. (579 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1356 aa)
ATF3Activating transcription factor 3. (181 aa)
RRAGDRas related GTP binding D. (400 aa)
LOC100983911BZIP domain-containing protein. (318 aa)
LARS1Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1177 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SESN3Sestrin 3. (522 aa)
GCN1GCN1 activator of EIF2AK4. (2666 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
LOC100980724BZIP domain-containing protein. (359 aa)
RRAGARas related GTP binding A. (313 aa)
C12orf66Chromosome 12 open reading frame 66. (468 aa)
ENSPPAP00000002562BZIP domain-containing protein. (314 aa)
KPTNKaptin, actin binding protein. (436 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (360 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RRAGBRas related GTP binding B. (374 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.