(15 nodes) Very-low-density lipoprotein particle network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APOB	Apolipoprotein B. (4535 aa)
	APOC3	Apolipoprotein C3. (99 aa)
	APOC2	Uncharacterized protein. (178 aa)
	APOH	Apolipoprotein H. (345 aa)
	APOA5	Apolipoprotein A5. (366 aa)
	APOA4	Apolipoprotein A4. (396 aa)
	PCYOX1	Prenylcysteine oxidase 1. (505 aa)
	APOE	Apolipoprotein E. (317 aa)
	APOO	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (199 aa)
	APOM	Apolipoprotein M. (188 aa)
	SELENOS	Uncharacterized protein. (218 aa)
	VLDLR	Very low density lipoprotein receptor. (1038 aa)
	LSR	Lipolysis stimulated lipoprotein receptor. (650 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family. (267 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOA1	APOA4	ENSPPAP00000007656	ENSPPAP00000028262	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein A4.	0.802
APOA1	APOA5	ENSPPAP00000007656	ENSPPAP00000035458	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein A5.	0.668
APOA1	APOB	ENSPPAP00000007656	ENSPPAP00000002804	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein B.	0.820
APOA1	APOC2	ENSPPAP00000007656	ENSPPAP00000039494	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Uncharacterized protein.	0.763
APOA1	APOC3	ENSPPAP00000007656	ENSPPAP00000003943	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein C3.	0.731
APOA1	APOE	ENSPPAP00000007656	ENSPPAP00000022762	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein E.	0.859
APOA1	APOH	ENSPPAP00000007656	ENSPPAP00000035480	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein H.	0.460
APOA1	APOM	ENSPPAP00000007656	ENSPPAP00000019117	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein M.	0.461
APOA1	LPL	ENSPPAP00000007656	ENSPPAP00000007103	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.624
APOA1	VLDLR	ENSPPAP00000007656	ENSPPAP00000012481	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Very low density lipoprotein receptor.	0.559
APOA4	APOA1	ENSPPAP00000028262	ENSPPAP00000007656	Apolipoprotein A4.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	0.802
APOA4	APOA5	ENSPPAP00000028262	ENSPPAP00000035458	Apolipoprotein A4.	Apolipoprotein A5.	0.805
APOA4	APOB	ENSPPAP00000028262	ENSPPAP00000002804	Apolipoprotein A4.	Apolipoprotein B.	0.906
APOA4	APOC2	ENSPPAP00000028262	ENSPPAP00000039494	Apolipoprotein A4.	Uncharacterized protein.	0.976
APOA4	APOC3	ENSPPAP00000028262	ENSPPAP00000003943	Apolipoprotein A4.	Apolipoprotein C3.	0.994
APOA4	APOE	ENSPPAP00000028262	ENSPPAP00000022762	Apolipoprotein A4.	Apolipoprotein E.	0.981
APOA4	APOH	ENSPPAP00000028262	ENSPPAP00000035480	Apolipoprotein A4.	Apolipoprotein H.	0.731
APOA4	APOM	ENSPPAP00000028262	ENSPPAP00000019117	Apolipoprotein A4.	Apolipoprotein M.	0.768
APOA4	LPL	ENSPPAP00000028262	ENSPPAP00000007103	Apolipoprotein A4.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.749
APOA4	PCYOX1	ENSPPAP00000028262	ENSPPAP00000028245	Apolipoprotein A4.	Prenylcysteine oxidase 1.	0.435