(7 nodes) Spherical high-density lipoprotein particle network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APOC3	Apolipoprotein C3. (99 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family. (267 aa)
	CLU	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
	APOM	Apolipoprotein M. (188 aa)
	PON1	Paraoxonase 1. (354 aa)
	ENSPPAP00000025875	Uncharacterized protein. (105 aa)
	APOC2	Uncharacterized protein. (178 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOA1	APOC2	ENSPPAP00000007656	ENSPPAP00000039494	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Uncharacterized protein.	0.763
APOA1	APOC3	ENSPPAP00000007656	ENSPPAP00000003943	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein C3.	0.731
APOA1	APOM	ENSPPAP00000007656	ENSPPAP00000019117	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein M.	0.461
APOA1	CLU	ENSPPAP00000007656	ENSPPAP00000014461	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.550
APOA1	PON1	ENSPPAP00000007656	ENSPPAP00000024829	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Paraoxonase 1.	0.479
APOC2	APOA1	ENSPPAP00000039494	ENSPPAP00000007656	Uncharacterized protein.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	0.763
APOC2	APOC3	ENSPPAP00000039494	ENSPPAP00000003943	Uncharacterized protein.	Apolipoprotein C3.	0.999
APOC2	APOM	ENSPPAP00000039494	ENSPPAP00000019117	Uncharacterized protein.	Apolipoprotein M.	0.741
APOC2	CLU	ENSPPAP00000039494	ENSPPAP00000014461	Uncharacterized protein.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.781
APOC2	PON1	ENSPPAP00000039494	ENSPPAP00000024829	Uncharacterized protein.	Paraoxonase 1.	0.660
APOC3	APOA1	ENSPPAP00000003943	ENSPPAP00000007656	Apolipoprotein C3.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	0.731
APOC3	APOC2	ENSPPAP00000003943	ENSPPAP00000039494	Apolipoprotein C3.	Uncharacterized protein.	0.999
APOC3	APOM	ENSPPAP00000003943	ENSPPAP00000019117	Apolipoprotein C3.	Apolipoprotein M.	0.812
APOC3	CLU	ENSPPAP00000003943	ENSPPAP00000014461	Apolipoprotein C3.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.701
APOC3	PON1	ENSPPAP00000003943	ENSPPAP00000024829	Apolipoprotein C3.	Paraoxonase 1.	0.762
APOM	APOA1	ENSPPAP00000019117	ENSPPAP00000007656	Apolipoprotein M.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	0.461
APOM	APOC2	ENSPPAP00000019117	ENSPPAP00000039494	Apolipoprotein M.	Uncharacterized protein.	0.741
APOM	APOC3	ENSPPAP00000019117	ENSPPAP00000003943	Apolipoprotein M.	Apolipoprotein C3.	0.812
APOM	CLU	ENSPPAP00000019117	ENSPPAP00000014461	Apolipoprotein M.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.706
APOM	PON1	ENSPPAP00000019117	ENSPPAP00000024829	Apolipoprotein M.	Paraoxonase 1.	0.682