(24 nodes) Plasma lipoprotein particle remodeling network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Your Input:
	LIPC	Lipase C, hepatic type. (490 aa)
	PLA2G2A	Phospholipase A(2). (144 aa)
	SCARB1	Uncharacterized protein; Belongs to the CD36 family. (498 aa)
	APOB	Apolipoprotein B. (4535 aa)
	APOC3	Apolipoprotein C3. (99 aa)
	PLA2G5	Phospholipase A(2). (138 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
	ABCA5	ATP binding cassette subfamily A member 5. (1631 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family. (267 aa)
	ABCG1	ABC transporter domain-containing protein. (807 aa)
	PLA2G3	Phospholipase A2 group III. (509 aa)
	APOM	Apolipoprotein M. (188 aa)
	LIPG	Lipase G, endothelial type. (500 aa)
	LCAT	Lecithin-cholesterol acyltransferase. (440 aa)
	PLA2G2E	Phospholipase A(2). (126 aa)
	PLA2G7	Platelet-activating factor acetylhydrolase. (441 aa)
	APOA4	Apolipoprotein A4. (396 aa)
	MTTP	Microsomal triglyceride transfer protein. (921 aa)
	LOC100990946	PA2c domain-containing protein. (147 aa)
	MPO	Myeloperoxidase. (745 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (466 aa)
	PLTP	Phospholipid transfer protein. (493 aa)
	APOA5	Apolipoprotein A5. (366 aa)
	APOC2	Uncharacterized protein. (178 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG1	APOB	ENSPPAP00000007960	ENSPPAP00000002804	ABC transporter domain-containing protein.	Apolipoprotein B.	0.573
ABCG1	CETP	ENSPPAP00000007960	ENSPPAP00000033549	ABC transporter domain-containing protein.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.641
ABCG1	LCAT	ENSPPAP00000007960	ENSPPAP00000024974	ABC transporter domain-containing protein.	Lecithin-cholesterol acyltransferase.	0.619
ABCG1	LPL	ENSPPAP00000007960	ENSPPAP00000007103	ABC transporter domain-containing protein.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.453
ABCG1	PLTP	ENSPPAP00000007960	ENSPPAP00000034390	ABC transporter domain-containing protein.	Phospholipid transfer protein.	0.473
ABCG1	SCARB1	ENSPPAP00000007960	ENSPPAP00000002618	ABC transporter domain-containing protein.	Uncharacterized protein; Belongs to the CD36 family.	0.671
APOA1	APOA4	ENSPPAP00000007656	ENSPPAP00000028262	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein A4.	0.802
APOA1	APOA5	ENSPPAP00000007656	ENSPPAP00000035458	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein A5.	0.668
APOA1	APOB	ENSPPAP00000007656	ENSPPAP00000002804	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein B.	0.820
APOA1	APOC2	ENSPPAP00000007656	ENSPPAP00000039494	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Uncharacterized protein.	0.763
APOA1	APOC3	ENSPPAP00000007656	ENSPPAP00000003943	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein C3.	0.731
APOA1	APOM	ENSPPAP00000007656	ENSPPAP00000019117	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein M.	0.461
APOA1	CETP	ENSPPAP00000007656	ENSPPAP00000033549	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.655
APOA1	LCAT	ENSPPAP00000007656	ENSPPAP00000024974	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Lecithin-cholesterol acyltransferase.	0.956
APOA1	LIPC	ENSPPAP00000007656	ENSPPAP00000000089	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Lipase C, hepatic type.	0.543
APOA1	LPL	ENSPPAP00000007656	ENSPPAP00000007103	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.624
APOA1	PLTP	ENSPPAP00000007656	ENSPPAP00000034390	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Phospholipid transfer protein.	0.746
APOA1	SCARB1	ENSPPAP00000007656	ENSPPAP00000002618	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	Uncharacterized protein; Belongs to the CD36 family.	0.407
APOA4	APOA1	ENSPPAP00000028262	ENSPPAP00000007656	Apolipoprotein A4.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity); Belongs to the apolipoprotein A1/A4/E family.	0.802
APOA4	APOA5	ENSPPAP00000028262	ENSPPAP00000035458	Apolipoprotein A4.	Apolipoprotein A5.	0.805