(12 nodes) Low-density lipoprotein particle remodeling network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MPO	Myeloperoxidase. (745 aa)
	LIPC	Lipase C, hepatic type. (490 aa)
	PLA2G2A	Phospholipase A(2). (144 aa)
	APOB	Apolipoprotein B. (4535 aa)
	PLA2G5	Phospholipase A(2). (138 aa)
	ABCG1	ABC transporter domain-containing protein. (807 aa)
	PLA2G3	Phospholipase A2 group III. (509 aa)
	PLA2G2E	Phospholipase A(2). (126 aa)
	PLA2G7	Platelet-activating factor acetylhydrolase. (441 aa)
	MTTP	Microsomal triglyceride transfer protein. (921 aa)
	LOC100990946	PA2c domain-containing protein. (147 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (466 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG1	APOB	ENSPPAP00000007960	ENSPPAP00000002804	ABC transporter domain-containing protein.	Apolipoprotein B.	0.573
ABCG1	CETP	ENSPPAP00000007960	ENSPPAP00000033549	ABC transporter domain-containing protein.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.641
APOB	ABCG1	ENSPPAP00000002804	ENSPPAP00000007960	Apolipoprotein B.	ABC transporter domain-containing protein.	0.573
APOB	CETP	ENSPPAP00000002804	ENSPPAP00000033549	Apolipoprotein B.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.947
APOB	LIPC	ENSPPAP00000002804	ENSPPAP00000000089	Apolipoprotein B.	Lipase C, hepatic type.	0.946
APOB	MPO	ENSPPAP00000002804	ENSPPAP00000033105	Apolipoprotein B.	Myeloperoxidase.	0.545
APOB	MTTP	ENSPPAP00000002804	ENSPPAP00000031074	Apolipoprotein B.	Microsomal triglyceride transfer protein.	0.997
APOB	PLA2G2E	ENSPPAP00000002804	ENSPPAP00000026016	Apolipoprotein B.	Phospholipase A(2).	0.818
APOB	PLA2G5	ENSPPAP00000002804	ENSPPAP00000004022	Apolipoprotein B.	Phospholipase A(2).	0.805
APOB	PLA2G7	ENSPPAP00000002804	ENSPPAP00000026805	Apolipoprotein B.	Platelet-activating factor acetylhydrolase.	0.721
CETP	ABCG1	ENSPPAP00000033549	ENSPPAP00000007960	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	ABC transporter domain-containing protein.	0.641
CETP	APOB	ENSPPAP00000033549	ENSPPAP00000002804	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Apolipoprotein B.	0.947
CETP	LIPC	ENSPPAP00000033549	ENSPPAP00000000089	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Lipase C, hepatic type.	0.825
CETP	MTTP	ENSPPAP00000033549	ENSPPAP00000031074	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Microsomal triglyceride transfer protein.	0.510
CETP	PLA2G7	ENSPPAP00000033549	ENSPPAP00000026805	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Platelet-activating factor acetylhydrolase.	0.592
LIPC	APOB	ENSPPAP00000000089	ENSPPAP00000002804	Lipase C, hepatic type.	Apolipoprotein B.	0.946
LIPC	CETP	ENSPPAP00000000089	ENSPPAP00000033549	Lipase C, hepatic type.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.825
LIPC	PLA2G7	ENSPPAP00000000089	ENSPPAP00000026805	Lipase C, hepatic type.	Platelet-activating factor acetylhydrolase.	0.476
LOC100990946	PLA2G2A	ENSPPAP00000032440	ENSPPAP00000000376	PA2c domain-containing protein.	Phospholipase A(2).	0.608
LOC100990946	PLA2G3	ENSPPAP00000032440	ENSPPAP00000012918	PA2c domain-containing protein.	Phospholipase A2 group III.	0.850