STRINGSTRING
HDAC3 HDAC3 KLF4 KLF4 P2RX7 P2RX7 SMAD6 SMAD6 TFPI2 TFPI2 XBP1 XBP1 MTSS1 MTSS1 ENSPPAP00000010419 ENSPPAP00000010419 LOC100982721 LOC100982721 HAS2 HAS2 PKD2 PKD2 SMAD7 SMAD7 TGFB1 TGFB1 TGFB3 TGFB3 SREBF2 SREBF2 ENSPPAP00000021246 ENSPPAP00000021246 ENSPPAP00000022875 ENSPPAP00000022875 ASS1 ASS1 MAP2K5 MAP2K5 NFE2L2 NFE2L2 PDGFRB PDGFRB ENSPPAP00000029448 ENSPPAP00000029448 PTK2B PTK2B ENSPPAP00000030737 ENSPPAP00000030737 NOS3 NOS3 MEF2C MEF2C MAPK7 MAPK7 MMP2 MMP2 AKT1 AKT1 ABCA1 ABCA1 SRC SRC ENSPPAP00000036285 ENSPPAP00000036285 CSF2 CSF2 P2RX4 P2RX4 PLEC PLEC LOC100981710 LOC100981710 PTGS2 PTGS2 CITED2 CITED2 ENSPPAP00000042325 ENSPPAP00000042325 SOCS5 SOCS5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
KLF4Kruppel like factor 4. (477 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
SMAD6Mothers against decapentaplegic homolog. (495 aa)
TFPI2Tissue factor pathway inhibitor. (235 aa)
XBP1BZIP domain-containing protein. (380 aa)
MTSS1MTSS I-BAR domain containing 1. (721 aa)
ENSPPAP00000010419Uncharacterized protein. (355 aa)
LOC100982721Uncharacterized protein. (245 aa)
HAS2Hyaluronan synthase 2. (552 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (788 aa)
SMAD7MH2 domain-containing protein. (211 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1140 aa)
ENSPPAP00000021246SOCS box domain-containing protein. (478 aa)
ENSPPAP00000022875Uncharacterized protein. (107 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ENSPPAP00000029448Uncharacterized protein. (397 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ENSPPAP00000030737Uncharacterized protein. (408 aa)
NOS3Nitric oxide synthase 3. (997 aa)
MEF2CMyocyte enhancer factor 2C. (482 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
MMP2Matrix metallopeptidase 2. (664 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
ABCA1ATP binding cassette subfamily A member 1. (2264 aa)
SRCTyrosine-protein kinase. (458 aa)
ENSPPAP00000036285Uncharacterized protein. (393 aa)
CSF2Colony stimulating factor 2. (144 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
PLECPlectin. (4523 aa)
LOC100981710Uncharacterized protein. (389 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CITED2Uncharacterized protein. (179 aa)
ENSPPAP00000042325Uncharacterized protein. (404 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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