STRINGSTRING
DDB2 DDB2 C9orf116 C9orf116 ACTR5 ACTR5 USP47 USP47 ENSPPAP00000002562 ENSPPAP00000002562 TAF1 TAF1 H2AW H2AW ENSPPAP00000003540 ENSPPAP00000003540 ENSPPAP00000003962 ENSPPAP00000003962 LOC100980724 LOC100980724 MME MME DHX36 DHX36 CHEK1 CHEK1 TREX1 TREX1 PTPRK PTPRK NFATC4 NFATC4 POLK POLK MYC MYC SIRT1 SIRT1 ENSPPAP00000007855 ENSPPAP00000007855 ENSPPAP00000008181 ENSPPAP00000008181 ENSPPAP00000009428 ENSPPAP00000009428 CUL4B CUL4B LOC100978286 LOC100978286 TP53 TP53 ENSPPAP00000011287 ENSPPAP00000011287 CRIP1 CRIP1 TIMP1 TIMP1 AURKB AURKB HYAL2 HYAL2 BAK1 BAK1 LOC100983911 LOC100983911 PPID PPID TRIAP1 TRIAP1 POLD1 POLD1 SMPD1 SMPD1 EIF2AK4 EIF2AK4 RBX1 RBX1 MFAP4 MFAP4 EP300 EP300 IMPACT IMPACT PCNA PCNA PRKCD PRKCD AQP1 AQP1 CUL4A CUL4A CDC25A CDC25A N4BP1 N4BP1 OPN3 OPN3 FBXW7 FBXW7 ENSPPAP00000024185 ENSPPAP00000024185 ZBTB1 ZBTB1 DDB1 DDB1 ST20 ST20 NOC2L NOC2L ERCC4 ERCC4 TP53INP1 TP53INP1 HYAL3 HYAL3 MMP3 MMP3 ENSPPAP00000027138 ENSPPAP00000027138 YY1 YY1 PBK PBK NEDD4 NEDD4 NSMCE3 NSMCE3 SDE2 SDE2 CDKN1A CDKN1A MAPK13 MAPK13 POLH POLH RUVBL2 RUVBL2 CREBBP CREBBP MMP9 MMP9 METTL3 METTL3 BMF BMF OPN5 OPN5 ATF4 ATF4 COPS9 COPS9 LOC100971311 LOC100971311 BAX BAX MMP2 MMP2 XPA XPA OPN1SW OPN1SW ENSPPAP00000035595 ENSPPAP00000035595 MMP1 MMP1 PARP1 PARP1 EIF2S1 EIF2S1 NPM1 NPM1 TMEM161A TMEM161A KDM1A KDM1A PIK3R1 PIK3R1 INO80 INO80 USP28 USP28 POLD3 POLD3 RPL26 RPL26 LOC100968388 LOC100968388 ATR ATR CASP1-2 CASP1-2 ENSPPAP00000040884 ENSPPAP00000040884 PTGS2 PTGS2 CASP9 CASP9 RHNO1 RHNO1 XPC XPC RHBDD1 RHBDD1 ERCC1 ERCC1 ENSPPAP00000042406 ENSPPAP00000042406 STK11 STK11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB2Damage specific DNA binding protein 2. (427 aa)
C9orf116Chromosome 9 open reading frame 116. (136 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (607 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
ENSPPAP00000002562BZIP domain-containing protein. (314 aa)
TAF1Transcription initiation factor TFIID subunit. (1916 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
ENSPPAP00000003540Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa)
ENSPPAP00000003962Uncharacterized protein. (69 aa)
LOC100980724BZIP domain-containing protein. (359 aa)
MMEMembrane metalloendopeptidase. (750 aa)
DHX36DEAH-box helicase 36. (1009 aa)
CHEK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa)
TREX1Three prime repair exonuclease 1. (369 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1472 aa)
NFATC4Nuclear factor of activated T cells 4. (963 aa)
POLKDNA polymerase kappa. (897 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
SIRT1Sirtuin 1. (693 aa)
ENSPPAP00000007855Uncharacterized protein. (192 aa)
ENSPPAP00000008181Uncharacterized protein. (130 aa)
ENSPPAP00000009428Uncharacterized protein. (295 aa)
CUL4BCullin 4B; Belongs to the cullin family. (932 aa)
LOC100978286Uncharacterized protein. (249 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ENSPPAP00000011287Uncharacterized protein. (271 aa)
CRIP1LIM zinc-binding domain-containing protein. (77 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
HYAL2Hyaluronidase. (473 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
LOC100983911BZIP domain-containing protein. (318 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
TRIAP1TP53 regulated inhibitor of apoptosis 1. (76 aa)
POLD1DNA polymerase. (1133 aa)
SMPD1Saposin B-type domain-containing protein. (504 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1734 aa)
RBX1Ring-box 1. (108 aa)
MFAP4Microfibril associated protein 4. (280 aa)
EP300E1A binding protein p300. (2411 aa)
IMPACTImpact RWD domain protein. (310 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
CUL4ACullin 4A; Belongs to the cullin family. (669 aa)
CDC25ACell division cycle 25A. (524 aa)
N4BP1NEDD4 binding protein 1. (896 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (408 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
ENSPPAP00000024185Uncharacterized protein. (49 aa)
ZBTB1Zinc finger and BTB domain containing 1. (661 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
ST20Uncharacterized protein. (79 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (712 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (240 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
ENSPPAP00000027138Uncharacterized protein. (279 aa)
YY1Uncharacterized protein. (370 aa)
PBKPDZ binding kinase. (324 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
NSMCE3NSE3 homolog, SMC5-SMC6 complex component. (291 aa)
SDE2SDE2 telomere maintenance homolog. (451 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
POLHDNA polymerase eta. (712 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
CREBBPCREB binding protein. (2414 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
BMFBcl2 modifying factor. (184 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ATF4Activating transcription factor 4. (340 aa)
COPS9COP9 signalosome subunit 9. (252 aa)
LOC100971311Uncharacterized protein. (261 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
MMP2Matrix metallopeptidase 2. (664 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
OPN1SWShort-wave-sensitive opsin 1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (By similarity). Involved in ensuring correct abundance and localization of retinal membrane proteins (By similarity). May increase spectral sensitivity in dim light (By similarity). (348 aa)
ENSPPAP00000035595Uncharacterized protein. (261 aa)
MMP1Matrix metallopeptidase 1. (469 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
NPM1Nucleophosmin 1. (294 aa)
TMEM161ATransmembrane protein 161A. (479 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
INO80INO80 complex ATPase subunit. (1556 aa)
USP28Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1177 aa)
POLD3Uncharacterized protein. (459 aa)
RPL26Ribosomal protein L26. (145 aa)
LOC100968388Uncharacterized protein. (273 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2614 aa)
CASP1-2CARD domain-containing protein. (95 aa)
ENSPPAP00000040884Uncharacterized protein. (263 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (238 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (946 aa)
RHBDD1Rhomboid domain containing 1. (315 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
ENSPPAP00000042406Uncharacterized protein. (234 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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