(82 nodes) Histone lysine methylation network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPPAP00000000062	MTS domain-containing protein. (220 aa)
	ENSPPAP00000000035	Uncharacterized protein. (81 aa)
	ENSPPAP00000008195	SET domain-containing protein. (347 aa)
	MEN1	Menin 1. (615 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2536 aa)
	SETD7	Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
	WDR5B	WD repeat domain 5B. (330 aa)
	H1-4	Histone cluster 1 H1 family member e. (219 aa)
	BOD1L1	Biorientation of chromosomes in cell division 1 like 1. (2968 aa)
	H1-2	Histone cluster 1 H1 family member c. (213 aa)
	H1-3	Histone cluster 1 H1 family member d. (221 aa)
	DYDC1	DPY30 domain containing 1. (177 aa)
	ENSPPAP00000001523	CBFD_NFYB_HMF domain-containing protein. (301 aa)
	RBBP5	RB binding protein 5, histone lysine methyltransferase complex subunit. (573 aa)
	PNO1	Partner of NOB1 homolog. (252 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (735 aa)
	TRMT112	tRNA methyltransferase subunit 11-2. (125 aa)
	SETMAR	SET domain and mariner transposase fusion gene. (684 aa)
	SMYD5	SMYD family member 5. (420 aa)
	SETDB2	SET domain bifurcated histone lysine methyltransferase 2. (719 aa)
	CTR9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
	DPY30	Dpy-30 histone methyltransferase complex regulatory subunit. (99 aa)
	SETD4	SET domain containing 4. (440 aa)
	SETD5	SET domain containing 5. (1461 aa)
	ENSPPAP00000036579	WD_REPEATS_REGION domain-containing protein. (59 aa)
	SETDB1	SET domain bifurcated histone lysine methyltransferase 1. (1292 aa)
	GCC1	GRIP and coiled-coil domain containing 1. (775 aa)
	NFYB	Nuclear transcription factor Y subunit beta. (208 aa)
	NFYA	Nuclear transcription factor Y subunit alpha. (347 aa)
	ASH2L	ASH2 like, histone lysine methyltransferase complex subunit. (639 aa)
	IZUMO4	IZUMO family member 4. (232 aa)
	ZNF335	Zinc finger protein 335. (1342 aa)
	ARID4A	AT-rich interaction domain 4A. (1259 aa)
	PRDM5	Zinc finger protein. (617 aa)
	SETD1B	SET domain containing 1B, histone lysine methyltransferase. (1926 aa)
	KMT5C	Lysine methyltransferase 5C. (390 aa)
	MLLT6	MLLT6, PHD finger containing. (1056 aa)
	HCFC1	Host cell factor C1. (2080 aa)
	SMYD3	SET and MYND domain containing 3. (428 aa)
	SETBP1	SET binding protein 1. (1395 aa)
	KMT2B	Lysine methyltransferase 2B. (2339 aa)
	KMT2D	Lysine methyltransferase 2D. (4780 aa)
	HCFC2	Host cell factor C2. (776 aa)
	KMT5B	Lysine methyltransferase 5B. (885 aa)
	BEND3	BEN domain containing 3. (827 aa)
	KDM3A	JmjC domain-containing protein. (1032 aa)
	DYDC2	DPY30 domain containing 2. (177 aa)
	SETD3	Protein-histidine N-methyltransferase. (594 aa)
	WDR61	WD repeat domain 61. (305 aa)
	N6AMT1	N-6 adenine-specific DNA methyltransferase 1. (214 aa)
	SMYD1	SET and MYND domain containing 1. (497 aa)
	PAXIP1	PAX interacting protein 1. (1052 aa)
	CHD5	Chromodomain helicase DNA binding protein 5. (1928 aa)
	DOT1L	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1637 aa)
	TET2	Tet methylcytosine dioxygenase 2. (2023 aa)
	EHMT1	Euchromatic histone lysine methyltransferase 1. (1298 aa)
	RLF	Rearranged L-myc fusion. (1914 aa)
	WDR82	WD repeat domain 82. (313 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (458 aa)
	ASH1L	ASH1 like histone lysine methyltransferase. (2923 aa)
	ARID4B	AT-rich interaction domain 4B. (1313 aa)
	PRDM7	KRAB-related domain-containing protein. (454 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
	TET3	Tet methylcytosine dioxygenase 3. (1795 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1278 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1057 aa)
	SUV39H2	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
	KDM6A	Lysine demethylase 6A. (1453 aa)
	WDR5	WD repeat domain 5. (334 aa)
	KMT2C	Lysine methyltransferase 2C. (4798 aa)
	SETD1A	Uncharacterized protein. (1397 aa)
	RTF1	RTF1 homolog, Paf1/RNA polymerase II complex component. (667 aa)
	SUV39H1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
	ENSPPAP00000013473	Uncharacterized protein. (518 aa)
	ENSPPAP00000013128	CBFD_NFYB_HMF domain-containing protein. (209 aa)
	KMT5A	SET domain-containing protein. (326 aa)
	PAGR1	PAXIP1 associated glutamate rich protein 1. (254 aa)
	PWP1	PWP1 homolog, endonuclein. (501 aa)
	SETD6	SET domain-containing protein. (361 aa)
	NSD2	Nuclear receptor binding SET domain protein 2. (1365 aa)
	CXXC1	CXXC finger protein 1. (667 aa)
	ENSPPAP00000008503	WD_REPEATS_REGION domain-containing protein. (308 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4A	ARID4B	ENSPPAP00000040208	ENSPPAP00000017196	AT-rich interaction domain 4A.	AT-rich interaction domain 4B.	0.561
ARID4A	ASH1L	ENSPPAP00000040208	ENSPPAP00000017744	AT-rich interaction domain 4A.	ASH1 like histone lysine methyltransferase.	0.505
ARID4A	CHD5	ENSPPAP00000040208	ENSPPAP00000021775	AT-rich interaction domain 4A.	Chromodomain helicase DNA binding protein 5.	0.671
ARID4A	CXXC1	ENSPPAP00000040208	ENSPPAP00000011359	AT-rich interaction domain 4A.	CXXC finger protein 1.	0.458
ARID4A	KDM6A	ENSPPAP00000040208	ENSPPAP00000015476	AT-rich interaction domain 4A.	Lysine demethylase 6A.	0.437
ARID4A	SETBP1	ENSPPAP00000040208	ENSPPAP00000029171	AT-rich interaction domain 4A.	SET binding protein 1.	0.505
ARID4A	SETD1A	ENSPPAP00000040208	ENSPPAP00000014612	AT-rich interaction domain 4A.	Uncharacterized protein.	0.444
ARID4A	SETD1B	ENSPPAP00000040208	ENSPPAP00000041411	AT-rich interaction domain 4A.	SET domain containing 1B, histone lysine methyltransferase.	0.444
ARID4A	SETD2	ENSPPAP00000040208	ENSPPAP00000007706	AT-rich interaction domain 4A.	SET domain containing 2, histone lysine methyltransferase.	0.527
ARID4A	TET2	ENSPPAP00000040208	ENSPPAP00000021483	AT-rich interaction domain 4A.	Tet methylcytosine dioxygenase 2.	0.417
ARID4A	TET3	ENSPPAP00000040208	ENSPPAP00000016426	AT-rich interaction domain 4A.	Tet methylcytosine dioxygenase 3.	0.417
ARID4B	ARID4A	ENSPPAP00000017196	ENSPPAP00000040208	AT-rich interaction domain 4B.	AT-rich interaction domain 4A.	0.561
ARID4B	ASH1L	ENSPPAP00000017196	ENSPPAP00000017744	AT-rich interaction domain 4B.	ASH1 like histone lysine methyltransferase.	0.720
ARID4B	CHD5	ENSPPAP00000017196	ENSPPAP00000021775	AT-rich interaction domain 4B.	Chromodomain helicase DNA binding protein 5.	0.671
ARID4B	CXXC1	ENSPPAP00000017196	ENSPPAP00000011359	AT-rich interaction domain 4B.	CXXC finger protein 1.	0.458
ARID4B	KDM6A	ENSPPAP00000017196	ENSPPAP00000015476	AT-rich interaction domain 4B.	Lysine demethylase 6A.	0.501
ARID4B	SETBP1	ENSPPAP00000017196	ENSPPAP00000029171	AT-rich interaction domain 4B.	SET binding protein 1.	0.505
ARID4B	SETD1A	ENSPPAP00000017196	ENSPPAP00000014612	AT-rich interaction domain 4B.	Uncharacterized protein.	0.434
ARID4B	SETD1B	ENSPPAP00000017196	ENSPPAP00000041411	AT-rich interaction domain 4B.	SET domain containing 1B, histone lysine methyltransferase.	0.434
ARID4B	SETD2	ENSPPAP00000017196	ENSPPAP00000007706	AT-rich interaction domain 4B.	SET domain containing 2, histone lysine methyltransferase.	0.567