(13 nodes) Protein folding in endoplasmic reticulum network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ERO1B	Endoplasmic reticulum oxidoreductase 1 beta. (441 aa)
	P4HB	Protein disulfide-isomerase. (513 aa)
	CANX	Calnexin. (592 aa)
	PDIA3	Protein disulfide-isomerase. (505 aa)
	PDIA2	Protein disulfide isomerase family A member 2. (525 aa)
	DNAJC3	DnaJ heat shock protein family (Hsp40) member C3. (497 aa)
	CALR	Calreticulin. (417 aa)
	ERO1A	Endoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
	ENSPPAP00000025633	Uncharacterized protein. (58 aa)
	ENSPPAP00000031464	Thioredoxin domain-containing protein. (484 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (814 aa)
	DNAJC10	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (793 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALR	CANX	ENSPPAP00000001484	ENSPPAP00000021763	Calreticulin.	Calnexin.	0.992
CALR	DNAJC10	ENSPPAP00000001484	ENSPPAP00000035387	Calreticulin.	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	0.811
CALR	DNAJC3	ENSPPAP00000001484	ENSPPAP00000002805	Calreticulin.	DnaJ heat shock protein family (Hsp40) member C3.	0.404
CALR	ENSPPAP00000025633	ENSPPAP00000001484	ENSPPAP00000025633	Calreticulin.	Uncharacterized protein.	0.978
CALR	ENSPPAP00000031464	ENSPPAP00000001484	ENSPPAP00000031464	Calreticulin.	Thioredoxin domain-containing protein.	0.991
CALR	HSP90B1	ENSPPAP00000001484	ENSPPAP00000032136	Calreticulin.	Heat shock protein 90 beta family member 1.	0.983
CALR	HSPA5	ENSPPAP00000001484	ENSPPAP00000040660	Calreticulin.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.952
CALR	P4HB	ENSPPAP00000001484	ENSPPAP00000024772	Calreticulin.	Protein disulfide-isomerase.	0.985
CALR	PDIA2	ENSPPAP00000001484	ENSPPAP00000010275	Calreticulin.	Protein disulfide isomerase family A member 2.	0.746
CALR	PDIA3	ENSPPAP00000001484	ENSPPAP00000015915	Calreticulin.	Protein disulfide-isomerase.	0.998
CANX	CALR	ENSPPAP00000021763	ENSPPAP00000001484	Calnexin.	Calreticulin.	0.992
CANX	DNAJC10	ENSPPAP00000021763	ENSPPAP00000035387	Calnexin.	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	0.776
CANX	DNAJC3	ENSPPAP00000021763	ENSPPAP00000002805	Calnexin.	DnaJ heat shock protein family (Hsp40) member C3.	0.431
CANX	ENSPPAP00000025633	ENSPPAP00000021763	ENSPPAP00000025633	Calnexin.	Uncharacterized protein.	0.844
CANX	ENSPPAP00000031464	ENSPPAP00000021763	ENSPPAP00000031464	Calnexin.	Thioredoxin domain-containing protein.	0.938
CANX	ERO1A	ENSPPAP00000021763	ENSPPAP00000024994	Calnexin.	Endoplasmic reticulum oxidoreductase 1 alpha.	0.526
CANX	HSP90B1	ENSPPAP00000021763	ENSPPAP00000032136	Calnexin.	Heat shock protein 90 beta family member 1.	0.882
CANX	HSPA5	ENSPPAP00000021763	ENSPPAP00000040660	Calnexin.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.962
CANX	P4HB	ENSPPAP00000021763	ENSPPAP00000024772	Calnexin.	Protein disulfide-isomerase.	0.863
CANX	PDIA2	ENSPPAP00000021763	ENSPPAP00000010275	Calnexin.	Protein disulfide isomerase family A member 2.	0.625