STRINGSTRING
CUL4A CUL4A MED14 MED14 MED27 MED27 YAP1 YAP1 SMC1A SMC1A MED6 MED6 RBPJ RBPJ BCL9L BCL9L SOX4 SOX4 SOX2 SOX2 STAT3 STAT3 SIX2 SIX2 BMPR1A BMPR1A FGF10 FGF10 ENSPPAP00000032512 ENSPPAP00000032512 NR2E1 NR2E1 CDKN2A CDKN2A NIPBL NIPBL SALL4 SALL4 VPS72 VPS72 SPI1 SPI1 ENSPPAP00000026998 ENSPPAP00000026998 BRAF BRAF RAF1 RAF1 MED28 MED28 SFRP1 SFRP1 MED30 MED30 KLF10 KLF10 LDB2 LDB2 WNT9B WNT9B LIG4 LIG4 KIT KIT CDX2 CDX2 MED12 MED12 NODAL NODAL ZFP36L2 ZFP36L2 LOC100976271 LOC100976271 MED21 MED21 NKAP NKAP SKI SKI WNT7A WNT7A MED15 MED15 BCL9 BCL9 LRP5 LRP5 GATA2 GATA2 MED7 MED7 ZHX2 ZHX2 LDB1 LDB1 RIF1 RIF1 KLF4 KLF4 LIF LIF NOG NOG REST REST HES1 HES1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CUL4ACullin 4A; Belongs to the cullin family. (669 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1466 aa)
MED27Mediator complex subunit 27. (311 aa)
YAP1Yes associated protein 1. (512 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
MED6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (249 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (499 aa)
BCL9LBCL9 like. (1483 aa)
SOX4HMG box domain-containing protein. (251 aa)
SOX2SRY-box transcription factor 2. (299 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
SIX2SIX homeobox 2. (291 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSPPAP00000032512Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (134 aa)
NR2E1Uncharacterized protein. (385 aa)
CDKN2AUncharacterized protein. (173 aa)
NIPBLNipped-B protein. (2804 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
VPS72Vacuolar protein sorting 72 homolog. (364 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
ENSPPAP00000026998Uncharacterized protein. (493 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
MED28Mediator complex subunit 28. (216 aa)
SFRP1NTR domain-containing protein. (178 aa)
MED30Mediator complex subunit 30. (178 aa)
KLF10Kruppel like factor 10. (480 aa)
LDB2LIM domain binding 2. (373 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (495 aa)
LIG4DNA ligase. (911 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
CDX2Caudal type homeobox 2. (313 aa)
MED12Mediator complex subunit 12. (2182 aa)
NODALNodal growth differentiation factor. (347 aa)
ZFP36L2Uncharacterized protein. (413 aa)
LOC100976271Uncharacterized protein. (249 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (159 aa)
NKAPNFKB activating protein. (415 aa)
SKISKI proto-oncogene. (666 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (785 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
LRP5LDL receptor related protein 5. (1839 aa)
GATA2GATA binding protein 2. (480 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (233 aa)
ZHX2Zinc fingers and homeoboxes 2. (837 aa)
LDB1LIM domain binding 1. (410 aa)
RIF1Replication timing regulatory factor 1. (2473 aa)
KLF4Kruppel like factor 4. (477 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
RESTRE1 silencing transcription factor. (1097 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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