(23 nodes) Cellular response to interferon-beta network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TREX1	Three prime repair exonuclease 1. (369 aa)
	UBE2K	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	MNDA	Myeloid cell nuclear differentiation antigen. (407 aa)
	STING1	Stimulator of interferon protein. (379 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
	UBE2G2	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
	IRGM	Immunity related GTPase M. (195 aa)
	IFI16	Interferon gamma inducible protein 16. (733 aa)
	OAS1	2',5'-oligoadenylate synthetase 1. (401 aa)
	ACOD1	Aconitate decarboxylase 1. (490 aa)
	PNPT1	Polyribonucleotide nucleotidyltransferase 1. (706 aa)
	CAPN2	Calpain 2; Belongs to the peptidase C2 family. (700 aa)
	IRGC	Immunity related GTPase cinema. (463 aa)
	ENSPPAP00000003907	Uncharacterized protein. (150 aa)
	PYDC5	Pyrin domain-containing protein. (113 aa)
	CDC34	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (233 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	ENSPPAP00000035415	Uncharacterized protein. (689 aa)
	PYHIN1	Pyrin and HIN domain family member 1. (483 aa)
	STAT1	Signal transducer and activator of transcription. (759 aa)
	IFITM2	Interferon induced transmembrane protein 2. (132 aa)
	AIM2	Absent in melanoma 2. (342 aa)
	IRF1	Interferon regulatory factor. (325 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	IFI16	ENSPPAP00000027408	ENSPPAP00000013418	Absent in melanoma 2.	Interferon gamma inducible protein 16.	0.975
AIM2	IRF1	ENSPPAP00000027408	ENSPPAP00000026442	Absent in melanoma 2.	Interferon regulatory factor.	0.497
AIM2	MNDA	ENSPPAP00000027408	ENSPPAP00000019524	Absent in melanoma 2.	Myeloid cell nuclear differentiation antigen.	0.425
AIM2	PYDC5	ENSPPAP00000027408	ENSPPAP00000003429	Absent in melanoma 2.	Pyrin domain-containing protein.	0.900
AIM2	STING1	ENSPPAP00000027408	ENSPPAP00000016620	Absent in melanoma 2.	Stimulator of interferon protein.	0.523
AIM2	TLR3	ENSPPAP00000027408	ENSPPAP00000016321	Absent in melanoma 2.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.526
CDC34	UBE2G2	ENSPPAP00000042374	ENSPPAP00000016313	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	0.547
CDC34	UBE2K	ENSPPAP00000042374	ENSPPAP00000019971	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.605
ENSPPAP00000003907	HTRA2	ENSPPAP00000003907	ENSPPAP00000036077	Uncharacterized protein.	HtrA serine peptidase 2.	0.535
ENSPPAP00000035415	TREX1	ENSPPAP00000035415	ENSPPAP00000005543	Uncharacterized protein.	Three prime repair exonuclease 1.	0.413
HTRA2	ENSPPAP00000003907	ENSPPAP00000036077	ENSPPAP00000003907	HtrA serine peptidase 2.	Uncharacterized protein.	0.535
IFI16	AIM2	ENSPPAP00000013418	ENSPPAP00000027408	Interferon gamma inducible protein 16.	Absent in melanoma 2.	0.975
IFI16	OAS1	ENSPPAP00000013418	ENSPPAP00000013370	Interferon gamma inducible protein 16.	2',5'-oligoadenylate synthetase 1.	0.623
IFI16	STAT1	ENSPPAP00000013418	ENSPPAP00000033854	Interferon gamma inducible protein 16.	Signal transducer and activator of transcription.	0.614
IFI16	STING1	ENSPPAP00000013418	ENSPPAP00000016620	Interferon gamma inducible protein 16.	Stimulator of interferon protein.	0.989
IFI16	TLR3	ENSPPAP00000013418	ENSPPAP00000016321	Interferon gamma inducible protein 16.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.514
IFITM2	OAS1	ENSPPAP00000031310	ENSPPAP00000013370	Interferon induced transmembrane protein 2.	2',5'-oligoadenylate synthetase 1.	0.424
IFITM2	STAT1	ENSPPAP00000031310	ENSPPAP00000033854	Interferon induced transmembrane protein 2.	Signal transducer and activator of transcription.	0.485
IRF1	AIM2	ENSPPAP00000026442	ENSPPAP00000027408	Interferon regulatory factor.	Absent in melanoma 2.	0.497
IRF1	OAS1	ENSPPAP00000026442	ENSPPAP00000013370	Interferon regulatory factor.	2',5'-oligoadenylate synthetase 1.	0.519