(23 nodes) Histone H2A monoubiquitination network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Your Input:
	PCGF6	RING-type domain-containing protein. (183 aa)
	ENSPPAP00000004466	MPN domain-containing protein. (294 aa)
	BCOR	BCL6 corepressor. (1755 aa)
	RNF2	Ring finger protein 2. (336 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (932 aa)
	PCGF3	Polycomb group ring finger 3. (242 aa)
	PCGF1	Polycomb group ring finger 1. (259 aa)
	LOC106635345	Uncharacterized protein; Belongs to the SKP1 family. (164 aa)
	RNF168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (570 aa)
	KDM2B	Lysine demethylase 2B. (1336 aa)
	DDB1	Damage specific DNA binding protein 1. (1147 aa)
	PCGF5	Polycomb group ring finger 5. (256 aa)
	TRIM37	Tripartite motif containing 37. (964 aa)
	PCGF2	Polycomb group ring finger 2. (344 aa)
	BABAM2	BRISC and BRCA1 A complex member 2. (415 aa)
	RYBP	RING1 and YY1 binding protein. (230 aa)
	BRCC3	BRCA1/BRCA2-containing complex subunit 3. (317 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
	BRCA2	BRCA2 DNA repair associated. (3417 aa)
	ENSPPAP00000039907	RAWUL domain-containing protein. (286 aa)
	BARD1	BRCA1 associated RING domain 1. (777 aa)
	DDB2	Damage specific DNA binding protein 2. (427 aa)
	RING1	E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...] (405 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BABAM2	BARD1	ENSPPAP00000032421	ENSPPAP00000041004	BRISC and BRCA1 A complex member 2.	BRCA1 associated RING domain 1.	0.957
BABAM2	BCOR	ENSPPAP00000032421	ENSPPAP00000008744	BRISC and BRCA1 A complex member 2.	BCL6 corepressor.	0.435
BABAM2	BRCA2	ENSPPAP00000032421	ENSPPAP00000000836	BRISC and BRCA1 A complex member 2.	BRCA2 DNA repair associated.	0.779
BABAM2	BRCC3	ENSPPAP00000032421	ENSPPAP00000034135	BRISC and BRCA1 A complex member 2.	BRCA1/BRCA2-containing complex subunit 3.	0.989
BABAM2	ENSPPAP00000004466	ENSPPAP00000032421	ENSPPAP00000004466	BRISC and BRCA1 A complex member 2.	MPN domain-containing protein.	0.989
BABAM2	RAD51	ENSPPAP00000032421	ENSPPAP00000038003	BRISC and BRCA1 A complex member 2.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.827
BABAM2	RNF168	ENSPPAP00000032421	ENSPPAP00000017541	BRISC and BRCA1 A complex member 2.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	0.638
BARD1	BABAM2	ENSPPAP00000041004	ENSPPAP00000032421	BRCA1 associated RING domain 1.	BRISC and BRCA1 A complex member 2.	0.957
BARD1	BCOR	ENSPPAP00000041004	ENSPPAP00000008744	BRCA1 associated RING domain 1.	BCL6 corepressor.	0.469
BARD1	BRCA2	ENSPPAP00000041004	ENSPPAP00000000836	BRCA1 associated RING domain 1.	BRCA2 DNA repair associated.	0.988
BARD1	BRCC3	ENSPPAP00000041004	ENSPPAP00000034135	BRCA1 associated RING domain 1.	BRCA1/BRCA2-containing complex subunit 3.	0.921
BARD1	ENSPPAP00000004466	ENSPPAP00000041004	ENSPPAP00000004466	BRCA1 associated RING domain 1.	MPN domain-containing protein.	0.921
BARD1	ENSPPAP00000039907	ENSPPAP00000041004	ENSPPAP00000039907	BRCA1 associated RING domain 1.	RAWUL domain-containing protein.	0.710
BARD1	PCGF2	ENSPPAP00000041004	ENSPPAP00000030513	BRCA1 associated RING domain 1.	Polycomb group ring finger 2.	0.423
BARD1	PCGF6	ENSPPAP00000041004	ENSPPAP00000038326	BRCA1 associated RING domain 1.	RING-type domain-containing protein.	0.423
BARD1	RAD51	ENSPPAP00000041004	ENSPPAP00000038003	BRCA1 associated RING domain 1.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.983
BARD1	RING1	ENSPPAP00000041004	ENSPPAP00000000507	BRCA1 associated RING domain 1.	E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...]	0.488
BARD1	RNF168	ENSPPAP00000041004	ENSPPAP00000017541	BRCA1 associated RING domain 1.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	0.740
BARD1	RNF2	ENSPPAP00000041004	ENSPPAP00000008813	BRCA1 associated RING domain 1.	Ring finger protein 2.	0.710
BCOR	BABAM2	ENSPPAP00000008744	ENSPPAP00000032421	BCL6 corepressor.	BRISC and BRCA1 A complex member 2.	0.435