(23 nodes) Regulation of urine volume network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	INPP5K	Inositol polyphosphate-5-phosphatase K. (448 aa)
	ADM	Adrenomedullin. (185 aa)
	AKR1B1	Aldo-keto reductase family 1 member B. (263 aa)
	ENSPPAP00000004989	Aldo_ket_red domain-containing protein. (269 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
	NPPB	Natriuretic peptide B. (134 aa)
	HYAL2	Hyaluronidase. (473 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	EDN1	Endothelin 1. (212 aa)
	TRPV5	Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (732 aa)
	HAS2	Hyaluronan synthase 2. (552 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
	NPR3	Natriuretic peptide receptor 3. (532 aa)
	TFAP2B	Transcription factor AP-2 beta. (467 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	ADORA2A	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
	ENSPPAP00000023190	Aldo_ket_red domain-containing protein. (294 aa)
	AVPR2	Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (371 aa)
	ENSPPAP00000024161	Aldo_ket_red domain-containing protein. (232 aa)
	NPR1	Guanylate cyclase. (1060 aa)
	UMOD	Uromodulin. (681 aa)
	SLC4A1	Anion exchange protein. (906 aa)
	MLLT6	MLLT6, PHD finger containing. (1056 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY6	AVPR2	ENSPPAP00000015584	ENSPPAP00000023362	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	0.613
ADCY6	GNAI2	ENSPPAP00000015584	ENSPPAP00000017425	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.941
ADM	EDN1	ENSPPAP00000000592	ENSPPAP00000013795	Adrenomedullin.	Endothelin 1.	0.671
ADM	NPPB	ENSPPAP00000000592	ENSPPAP00000010371	Adrenomedullin.	Natriuretic peptide B.	0.452
ADM	NPR1	ENSPPAP00000000592	ENSPPAP00000024632	Adrenomedullin.	Guanylate cyclase.	0.463
ADORA2A	DRD2	ENSPPAP00000018245	ENSPPAP00000013663	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.962
AVPR2	ADCY6	ENSPPAP00000023362	ENSPPAP00000015584	Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.613
AVPR2	EDN1	ENSPPAP00000023362	ENSPPAP00000013795	Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	Endothelin 1.	0.553
DRD2	ADORA2A	ENSPPAP00000013663	ENSPPAP00000018245	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	0.962
DRD2	EDN1	ENSPPAP00000013663	ENSPPAP00000013795	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.722
DRD2	GNAI2	ENSPPAP00000013663	ENSPPAP00000017425	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha i2.	0.977
EDN1	ADM	ENSPPAP00000013795	ENSPPAP00000000592	Endothelin 1.	Adrenomedullin.	0.671
EDN1	AVPR2	ENSPPAP00000013795	ENSPPAP00000023362	Endothelin 1.	Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	0.553
EDN1	DRD2	ENSPPAP00000013795	ENSPPAP00000013663	Endothelin 1.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.722
EDN1	EDNRB	ENSPPAP00000013795	ENSPPAP00000008765	Endothelin 1.	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.999
EDN1	NPPB	ENSPPAP00000013795	ENSPPAP00000010371	Endothelin 1.	Natriuretic peptide B.	0.473
EDNRB	EDN1	ENSPPAP00000008765	ENSPPAP00000013795	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.999
EDNRB	GNAI2	ENSPPAP00000008765	ENSPPAP00000017425	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha i2.	0.921
GNAI2	ADCY6	ENSPPAP00000017425	ENSPPAP00000015584	G protein subunit alpha i2.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.941
GNAI2	DRD2	ENSPPAP00000017425	ENSPPAP00000013663	G protein subunit alpha i2.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.977