(17 nodes) Atrioventricular canal development network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HAS2	Hyaluronan synthase 2. (552 aa)
	ENG	Endoglin. (658 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2997 aa)
	TBX20	Uncharacterized protein. (379 aa)
	ENSPPAP00000024034	Uncharacterized protein. (541 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (499 aa)
	FOXN4	Forkhead box N4. (512 aa)
	ENSPPAP00000029143	Uncharacterized protein. (511 aa)
	GATA4	GATA binding protein 4. (396 aa)
	GATA6	Uncharacterized protein. (402 aa)
	ENSPPAP00000006969	Uncharacterized protein. (584 aa)
	ENSPPAP00000009275	Uncharacterized protein. (269 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	TBX3	T-box transcription factor 3. (723 aa)
	BMP2	Bone morphogenetic protein 2. (396 aa)
	TBX2	T-box transcription factor 2. (622 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	ENG	ENSPPAP00000014674	ENSPPAP00000016080	Bone morphogenetic protein 2.	Endoglin.	0.653
BMP2	GATA4	ENSPPAP00000014674	ENSPPAP00000000601	Bone morphogenetic protein 2.	GATA binding protein 4.	0.500
BMP2	SMAD4	ENSPPAP00000014674	ENSPPAP00000009478	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.882
BMP2	TBX2	ENSPPAP00000014674	ENSPPAP00000015093	Bone morphogenetic protein 2.	T-box transcription factor 2.	0.406
BMP2	TBX3	ENSPPAP00000014674	ENSPPAP00000010916	Bone morphogenetic protein 2.	T-box transcription factor 3.	0.477
ENG	BMP2	ENSPPAP00000016080	ENSPPAP00000014674	Endoglin.	Bone morphogenetic protein 2.	0.653
ENG	SMAD4	ENSPPAP00000016080	ENSPPAP00000009478	Endoglin.	Mothers against decapentaplegic homolog.	0.568
FOXN4	SMAD4	ENSPPAP00000031267	ENSPPAP00000009478	Forkhead box N4.	Mothers against decapentaplegic homolog.	0.426
GATA4	BMP2	ENSPPAP00000000601	ENSPPAP00000014674	GATA binding protein 4.	Bone morphogenetic protein 2.	0.500
GATA4	GATA6	ENSPPAP00000000601	ENSPPAP00000003349	GATA binding protein 4.	Uncharacterized protein.	0.496
GATA4	TBX2	ENSPPAP00000000601	ENSPPAP00000015093	GATA binding protein 4.	T-box transcription factor 2.	0.407
GATA4	TBX20	ENSPPAP00000000601	ENSPPAP00000020526	GATA binding protein 4.	Uncharacterized protein.	0.848
GATA4	TBX3	ENSPPAP00000000601	ENSPPAP00000010916	GATA binding protein 4.	T-box transcription factor 3.	0.577
GATA6	GATA4	ENSPPAP00000003349	ENSPPAP00000000601	Uncharacterized protein.	GATA binding protein 4.	0.496
GATA6	SMAD4	ENSPPAP00000003349	ENSPPAP00000009478	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.566
GATA6	TBX20	ENSPPAP00000003349	ENSPPAP00000020526	Uncharacterized protein.	Uncharacterized protein.	0.616
GATA6	TBX3	ENSPPAP00000003349	ENSPPAP00000010916	Uncharacterized protein.	T-box transcription factor 3.	0.485
RBPJ	SMAD4	ENSPPAP00000038680	ENSPPAP00000009478	Recombination signal binding protein for immunoglobulin kappa J region.	Mothers against decapentaplegic homolog.	0.455
SMAD4	BMP2	ENSPPAP00000009478	ENSPPAP00000014674	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 2.	0.882
SMAD4	ENG	ENSPPAP00000009478	ENSPPAP00000016080	Mothers against decapentaplegic homolog.	Endoglin.	0.568