(21 nodes) Dendritic cell migration network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ASB2	Ankyrin repeat and SOCS box containing 2. (625 aa)
	EPS8	Epidermal growth factor receptor pathway substrate 8. (822 aa)
	ALOX5	Arachidonate 5-lipoxygenase. (674 aa)
	DOCK8	Dedicator of cytokinesis 8; Belongs to the DOCK family. (2099 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	CCL5	C-C motif chemokine. (91 aa)
	NLRP12	NLR family pyrin domain containing 12. (1005 aa)
	ARHGEF5	Rho guanine nucleotide exchange factor 5. (1597 aa)
	CCR1	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	CCL21	C-C motif chemokine ligand 21. (134 aa)
	CCR2	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	CDC42	Uncharacterized protein. (191 aa)
	TRPM4	Transient receptor potential cation channel subfamily M member 4. (1138 aa)
	LOC100993131	Cell division control protein 42 homolog. (191 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	CCL19	C-C motif chemokine. (98 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	ANO6	Anoctamin. (906 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2. (1552 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF5	CDC42	ENSPPAP00000006814	ENSPPAP00000015981	Rho guanine nucleotide exchange factor 5.	Uncharacterized protein.	0.501
ARHGEF5	LOC100993131	ENSPPAP00000006814	ENSPPAP00000017950	Rho guanine nucleotide exchange factor 5.	Cell division control protein 42 homolog.	0.501
CCL19	CCL21	ENSPPAP00000020066	ENSPPAP00000003129	C-C motif chemokine.	C-C motif chemokine ligand 21.	0.926
CCL19	CCL5	ENSPPAP00000020066	ENSPPAP00000042652	C-C motif chemokine.	C-C motif chemokine.	0.467
CCL19	CCR1	ENSPPAP00000020066	ENSPPAP00000006430	C-C motif chemokine.	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.830
CCL19	CCR2	ENSPPAP00000020066	ENSPPAP00000002177	C-C motif chemokine.	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.872
CCL19	CCR6	ENSPPAP00000020066	ENSPPAP00000025564	C-C motif chemokine.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.843
CCL19	CCR7	ENSPPAP00000020066	ENSPPAP00000039258	C-C motif chemokine.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.991
CCL21	CCL19	ENSPPAP00000003129	ENSPPAP00000020066	C-C motif chemokine ligand 21.	C-C motif chemokine.	0.926
CCL21	CCL5	ENSPPAP00000003129	ENSPPAP00000042652	C-C motif chemokine ligand 21.	C-C motif chemokine.	0.996
CCL21	CCR1	ENSPPAP00000003129	ENSPPAP00000006430	C-C motif chemokine ligand 21.	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.920
CCL21	CCR2	ENSPPAP00000003129	ENSPPAP00000002177	C-C motif chemokine ligand 21.	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.924
CCL21	CCR6	ENSPPAP00000003129	ENSPPAP00000025564	C-C motif chemokine ligand 21.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.911
CCL21	CCR7	ENSPPAP00000003129	ENSPPAP00000039258	C-C motif chemokine ligand 21.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.998
CCL21	GPR183	ENSPPAP00000003129	ENSPPAP00000018809	C-C motif chemokine ligand 21.	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family.	0.431
CCL5	CCL19	ENSPPAP00000042652	ENSPPAP00000020066	C-C motif chemokine.	C-C motif chemokine.	0.467
CCL5	CCL21	ENSPPAP00000042652	ENSPPAP00000003129	C-C motif chemokine.	C-C motif chemokine ligand 21.	0.996
CCL5	CCR1	ENSPPAP00000042652	ENSPPAP00000006430	C-C motif chemokine.	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.998
CCL5	CCR2	ENSPPAP00000042652	ENSPPAP00000002177	C-C motif chemokine.	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.993
CCL5	CCR6	ENSPPAP00000042652	ENSPPAP00000025564	C-C motif chemokine.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.920