(20 nodes) Post-anal tail morphogenesis network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PALB2	Partner and localizer of BRCA2. (1186 aa)
	EPHA2	EPH receptor A2. (976 aa)
	SP5	Uncharacterized protein. (330 aa)
	DCHS1	Dachsous cadherin-related 1. (3175 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	TMED2	Transmembrane p24 trafficking protein 2. (208 aa)
	RIPPLY2	Ripply transcriptional repressor 2. (128 aa)
	ENSPPAP00000023291	GOLD domain-containing protein; Belongs to the EMP24/GP25L family. (156 aa)
	LRRC1	Leucine rich repeat containing 1. (524 aa)
	HES7	BHLH domain-containing protein. (129 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	MED12	Mediator complex subunit 12. (2182 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	AXIN1	Axin 1. (862 aa)
	TBXT	T-box transcription factor T. (435 aa)
	CHST11	Carbohydrate sulfotransferase. (352 aa)
	SCRIB	Scribble planar cell polarity protein. (1656 aa)
	ENSPPAP00000011807	GOLD domain-containing protein. (200 aa)
	TCF15	BHLH domain-containing protein. (108 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN1	FZD3	ENSPPAP00000016161	ENSPPAP00000018635	Axin 1.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.470
AXIN1	WNT3A	ENSPPAP00000016161	ENSPPAP00000020568	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.803
AXIN1	WNT5A	ENSPPAP00000016161	ENSPPAP00000008134	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.618
FZD3	AXIN1	ENSPPAP00000018635	ENSPPAP00000016161	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Axin 1.	0.470
FZD3	SCRIB	ENSPPAP00000018635	ENSPPAP00000012382	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Scribble planar cell polarity protein.	0.402
FZD3	WNT3A	ENSPPAP00000018635	ENSPPAP00000020568	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.936
FZD3	WNT5A	ENSPPAP00000018635	ENSPPAP00000008134	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.992
SCRIB	FZD3	ENSPPAP00000012382	ENSPPAP00000018635	Scribble planar cell polarity protein.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.402
WNT3A	AXIN1	ENSPPAP00000020568	ENSPPAP00000016161	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Axin 1.	0.803
WNT3A	FZD3	ENSPPAP00000020568	ENSPPAP00000018635	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.936
WNT5A	AXIN1	ENSPPAP00000008134	ENSPPAP00000016161	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Axin 1.	0.618
WNT5A	FZD3	ENSPPAP00000008134	ENSPPAP00000018635	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.992