(31 nodes) Neurotrophin signaling pathway network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
	AKT1S1	AKT1 substrate 1. (276 aa)
	NTRK3	Tyrosine-protein kinase receptor. (864 aa)
	KIDINS220	Kinase D interacting substrate 220. (1754 aa)
	SRC	Tyrosine-protein kinase. (458 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1095 aa)
	ENSPPAP00000035001	Uncharacterized protein. (110 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	NGF	NGF domain-containing protein; Belongs to the NGF-beta family. (123 aa)
	MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1256 aa)
	NTRK2	Tyrosine-protein kinase receptor. (838 aa)
	ENSPPAP00000029143	Uncharacterized protein. (511 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	ENSPPAP00000024034	Uncharacterized protein. (541 aa)
	SORT1	Sortilin. (569 aa)
	NTRK1	Tyrosine-protein kinase receptor. (796 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (916 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	GFRA1	GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (467 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1611 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	ZFYVE27	Zinc finger FYVE-type containing 27. (416 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
	HAP1	Huntingtin associated protein 1. (669 aa)
	ENSPPAP00000009275	Uncharacterized protein. (269 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
	DDIT4	DNA damage inducible transcript 4. (232 aa)
	ENSPPAP00000006969	Uncharacterized protein. (584 aa)
	NTF4	Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
	NDN	MAGE domain-containing protein. (261 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAR1	ENSPPAP00000035001	ENSPPAP00000019881	ENSPPAP00000035001	BCAR1 scaffold protein, Cas family member.	Uncharacterized protein.	0.400
BCAR1	RAP1A	ENSPPAP00000019881	ENSPPAP00000034589	BCAR1 scaffold protein, Cas family member.	RAP1A, member of RAS oncogene family.	0.414
BCAR1	RAPGEF1	ENSPPAP00000019881	ENSPPAP00000035151	BCAR1 scaffold protein, Cas family member.	Rap guanine nucleotide exchange factor 1.	0.965
BCAR1	SRC	ENSPPAP00000019881	ENSPPAP00000035810	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.999
BDNF	CASP3	ENSPPAP00000012096	ENSPPAP00000013228	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Caspase 3; Belongs to the peptidase C14A family.	0.538
BDNF	GFRA1	ENSPPAP00000012096	ENSPPAP00000017089	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family.	0.712
BDNF	HAP1	ENSPPAP00000012096	ENSPPAP00000009775	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Huntingtin associated protein 1.	0.602
BDNF	NGF	ENSPPAP00000012096	ENSPPAP00000034057	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	NGF domain-containing protein; Belongs to the NGF-beta family.	0.741
BDNF	NTF3	ENSPPAP00000012096	ENSPPAP00000041473	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.704
BDNF	NTF4	ENSPPAP00000012096	ENSPPAP00000005402	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Neurotrophin 4; Belongs to the NGF-beta family.	0.978
BDNF	NTRK1	ENSPPAP00000012096	ENSPPAP00000022872	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.990
BDNF	NTRK2	ENSPPAP00000012096	ENSPPAP00000029510	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.998
BDNF	NTRK3	ENSPPAP00000012096	ENSPPAP00000039788	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.978
BDNF	SORT1	ENSPPAP00000012096	ENSPPAP00000023886	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Sortilin.	0.958
BDNF	SOS1	ENSPPAP00000012096	ENSPPAP00000008514	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.527
BDNF	SRC	ENSPPAP00000012096	ENSPPAP00000035810	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase.	0.672
CASP3	BDNF	ENSPPAP00000013228	ENSPPAP00000012096	Caspase 3; Belongs to the peptidase C14A family.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.538
CASP3	NGF	ENSPPAP00000013228	ENSPPAP00000034057	Caspase 3; Belongs to the peptidase C14A family.	NGF domain-containing protein; Belongs to the NGF-beta family.	0.739
CASP3	NTRK1	ENSPPAP00000013228	ENSPPAP00000022872	Caspase 3; Belongs to the peptidase C14A family.	Tyrosine-protein kinase receptor.	0.442
CASP3	NTRK2	ENSPPAP00000013228	ENSPPAP00000029510	Caspase 3; Belongs to the peptidase C14A family.	Tyrosine-protein kinase receptor.	0.442