STRINGSTRING
FBXL22 FBXL22 PRKAA2 PRKAA2 TOP2A TOP2A PER2 PER2 MAPK10 MAPK10 NR1D1 NR1D1 NOCT NOCT CIPC CIPC PASD1 PASD1 KAT5 KAT5 LOC100972235 LOC100972235 HCRTR2 HCRTR2 OPN4 OPN4 PTGDS PTGDS LOC100975187 LOC100975187 FBXW11 FBXW11 CSF2 CSF2 CCAR2 CCAR2 MTA1 MTA1 GSK3B GSK3B ENSPPAP00000036081 ENSPPAP00000036081 PER1 PER1 ATG7 ATG7 CDK1 CDK1 ARNTL2 ARNTL2 USP9X USP9X PPARA PPARA ADCY1 ADCY1 OPN5 OPN5 NR1H3 NR1H3 ROCK2 ROCK2 GNA11 GNA11 RORA RORA MAPK9 MAPK9 KDM2A KDM2A HNF4A HNF4A UBE3A UBE3A PDE6B PDE6B MAGED1 MAGED1 HDAC3 HDAC3 SRRD SRRD USP7 USP7 MAGEL2 MAGEL2 MTOR MTOR PRKAA1 PRKAA1 HNRNPD HNRNPD DDB1 DDB1 TIMELESS TIMELESS GHRH GHRH PROX1 PROX1 FBXW7 FBXW7 OPN3 OPN3 PPARGC1A PPARGC1A LOC100975570 LOC100975570 FBXL12 FBXL12 BTRC BTRC ID2 ID2 SIRT6 SIRT6 ZFHX3 ZFHX3 FBXL8 FBXL8 FBXL6 FBXL6 CRY2 CRY2 KLF10 KLF10 NR1D2 NR1D2 PIWIL2 PIWIL2 BHLHE40 BHLHE40 NONO NONO ADORA2A ADORA2A CHRNB2 CHRNB2 ENSPPAP00000017065 ENSPPAP00000017065 EZH2 EZH2 SIN3A SIN3A SUV39H2 SUV39H2 ENSPPAP00000015326 ENSPPAP00000015326 MTNR1B MTNR1B PHLPP1 PHLPP1 NLGN1 NLGN1 SFPQ SFPQ ENSPPAP00000013852 ENSPPAP00000013852 PPP1CC PPP1CC PRKDC PRKDC SUV39H1 SUV39H1 SPSB4 SPSB4 PRKCG PRKCG PML PML CLOCK CLOCK GHRHR GHRHR ENSPPAP00000012418 ENSPPAP00000012418 PPP1CB PPP1CB PPARG PPARG THRAP3 THRAP3 TP53 TP53 FBXL17 FBXL17 NPS NPS FBXW9 FBXW9 GNAQ GNAQ PER3 PER3 SIAH2 SIAH2 FBXL3 FBXL3 RORB RORB NR2F6 NR2F6 RORC RORC USP2 USP2 GHRL GHRL ENSPPAP00000006357 ENSPPAP00000006357 CSNK1D CSNK1D PPP1CA PPP1CA CRH CRH KCNA2 KCNA2 RBM4B RBM4B ARNTL ARNTL CRY1 CRY1 PSPC1 PSPC1 NKX2-1 NKX2-1 ENSPPAP00000001475 ENSPPAP00000001475 MAPK8 MAPK8 ENSPPAP00000001242 ENSPPAP00000001242 CRTC1 CRTC1 SOX14 SOX14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FBXL22F-box and leucine rich repeat protein 22. (247 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1521 aa)
PER2Period circadian regulator 2. (1255 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (614 aa)
NOCTNocturnin. (394 aa)
CIPCCLOCK interacting pacemaker. (399 aa)
PASD1PAS domain containing repressor 1. (788 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
LOC100972235F-box domain-containing protein. (432 aa)
HCRTR2Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family. (444 aa)
OPN4Opsin 4. (499 aa)
PTGDSLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
LOC100975187Uncharacterized protein. (446 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
CSF2Colony stimulating factor 2. (144 aa)
CCAR2Cell cycle and apoptosis regulator 2. (930 aa)
MTA1Uncharacterized protein. (875 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
ENSPPAP00000036081Uncharacterized protein. (302 aa)
PER1Period circadian regulator 1. (1290 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (624 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2576 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (353 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
GNA11G protein subunit alpha 11. (319 aa)
RORARAR related orphan receptor A. (559 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
KDM2ALysine demethylase 2A. (1162 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (867 aa)
PDE6BPhosphodiesterase. (805 aa)
MAGED1MAGE family member D1. (834 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
SRRDSRR1 domain containing. (317 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1109 aa)
MAGEL2MAGE family member L2. (1221 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (349 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
TIMELESSTimeless circadian regulator. (1208 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
PROX1Prospero homeobox 1. (737 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (408 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
LOC100975570Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
FBXL12F-box and leucine rich repeat protein 12. (326 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
SIRT6Sirtuin 6. (355 aa)
ZFHX3Zinc finger homeobox 3. (3607 aa)
FBXL8F-box domain-containing protein. (328 aa)
FBXL6F-box domain-containing protein. (670 aa)
CRY2Cryptochrome circadian regulator 2. (614 aa)
KLF10Kruppel like factor 10. (480 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (580 aa)
PIWIL2Uncharacterized protein; Belongs to the argonaute family. (974 aa)
BHLHE40Basic helix-loop-helix family member e40. (414 aa)
NONONon-POU domain containing octamer binding. (471 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (502 aa)
ENSPPAP00000017065SER_THR_PHOSPHATASE domain-containing protein. (297 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
ENSPPAP00000015326HECT domain-containing protein. (670 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PHLPP1Uncharacterized protein. (1322 aa)
NLGN1Neuroligin 1. (823 aa)
SFPQSplicing factor proline and glutamine rich. (709 aa)
ENSPPAP00000013852RRM domain-containing protein. (161 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
SPSB4SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PMLUncharacterized protein. (836 aa)
CLOCKClock circadian regulator. (847 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
ENSPPAP00000012418Uncharacterized protein. (412 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
THRAP3Thyroid hormone receptor associated protein 3. (954 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
FBXL17F-box domain-containing protein. (445 aa)
NPSNeuropeptide S. (89 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
GNAQG protein subunit alpha q. (313 aa)
PER3Period circadian regulator 3. (1211 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (271 aa)
FBXL3F-box and leucine rich repeat protein 3. (428 aa)
RORBRAR related orphan receptor B. (482 aa)
NR2F6Uncharacterized protein. (326 aa)
RORCRAR related orphan receptor C. (525 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (605 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
ENSPPAP00000006357RRM domain-containing protein. (228 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (427 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (334 aa)
CRHCorticotropin releasing hormone. (196 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (628 aa)
CRY1Cryptochrome circadian regulator 1. (586 aa)
PSPC1Paraspeckle component 1. (443 aa)
NKX2-1Uncharacterized protein. (126 aa)
ENSPPAP00000001475TDP43_N domain-containing protein. (112 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSPPAP00000001242BHLH domain-containing protein. (117 aa)
CRTC1CREB regulated transcription coactivator 1. (622 aa)
SOX14SRY-box transcription factor 14. (240 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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