(46 nodes) Negative regulation of I-kappaB kinase/NF-kappaB signaling network (Pan paniscus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	STAT1	Signal transducer and activator of transcription. (759 aa)
	PPM1B	Protein phosphatase, Mg2+/Mn2+ dependent 1B. (479 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (286 aa)
	GSTP1	Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
	CARD8	Caspase recruitment domain family member 8. (537 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (614 aa)
	ZMYND11	Zinc finger MYND-type containing 11. (648 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (599 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	PER1	Period circadian regulator 1. (1290 aa)
	TRIM39	Tripartite motif containing 39. (518 aa)
	LILRB4	Leukocyte immunoglobulin like receptor B4. (408 aa)
	TANK	TRAF family member associated NFKB activator. (425 aa)
	OTUD7A	OTU domain-containing protein. (755 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
	RHOH	Ras homolog family member H. (191 aa)
	TNIP3	TNFAIP3 interacting protein 3. (376 aa)
	NLRX1	NLR family member X1. (975 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	TNIP1	TNFAIP3 interacting protein 1. (645 aa)
	SIRT1	Sirtuin 1. (693 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (802 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (482 aa)
	OTUD7B	OTU deubiquitinase 7B. (841 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (805 aa)
	CACTIN	Cactin, spliceosome C complex subunit. (710 aa)
	NLRP12	NLR family pyrin domain containing 12. (1005 aa)
	RIOK3	Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (603 aa)
	NLRP6	NLR family pyrin domain containing 6. (892 aa)
	PPM1N	PP2C_C domain-containing protein. (130 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (496 aa)
	ASH1L	ASH1 like histone lysine methyltransferase. (2923 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	CARD19	Caspase recruitment domain family member 19. (183 aa)
	NLRC3	NLR family CARD domain containing 3. (1112 aa)
	TNFAIP3	TNF alpha induced protein 3. (784 aa)
	ENSPPAP00000024044	PPM-type phosphatase domain-containing protein. (75 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	ENSPPAP00000027817	Uncharacterized protein. (56 aa)
	TLE1	TLE family member 1, transcriptional corepressor. (779 aa)
	RORA	RAR related orphan receptor A. (559 aa)
	OPTN	Optineurin. (577 aa)
	DAB2IP	DAB2 interacting protein. (1155 aa)
	CCDC22	Coiled-coil domain containing 22. (627 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ESR1	ENSPPAP00000026444	ENSPPAP00000006837	Tyrosine-protein kinase.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.419
ABL1	RHOH	ENSPPAP00000026444	ENSPPAP00000001360	Tyrosine-protein kinase.	Ras homolog family member H.	0.403
ABL1	STAT1	ENSPPAP00000026444	ENSPPAP00000033854	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.604
ADIPOQ	SIRT1	ENSPPAP00000042063	ENSPPAP00000007254	Adiponectin, C1Q and collagen domain containing.	Sirtuin 1.	0.678
CACTIN	TRIM39	ENSPPAP00000009948	ENSPPAP00000035817	Cactin, spliceosome C complex subunit.	Tripartite motif containing 39.	0.553
CARD8	NLRP6	ENSPPAP00000041042	ENSPPAP00000014381	Caspase recruitment domain family member 8.	NLR family pyrin domain containing 6.	0.543
CARD8	PYCARD	ENSPPAP00000041042	ENSPPAP00000040974	Caspase recruitment domain family member 8.	PYD and CARD domain containing.	0.869
CASP8	ESR1	ENSPPAP00000015206	ENSPPAP00000006837	Caspase 8; Belongs to the peptidase C14A family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.533
CASP8	NR1H4	ENSPPAP00000015206	ENSPPAP00000007723	Caspase 8; Belongs to the peptidase C14A family.	Nuclear receptor subfamily 1 group H member 4.	0.435
CASP8	PYCARD	ENSPPAP00000015206	ENSPPAP00000040974	Caspase 8; Belongs to the peptidase C14A family.	PYD and CARD domain containing.	0.912
CASP8	RIPK1	ENSPPAP00000015206	ENSPPAP00000009086	Caspase 8; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 1.	0.999
CASP8	STAT1	ENSPPAP00000015206	ENSPPAP00000033854	Caspase 8; Belongs to the peptidase C14A family.	Signal transducer and activator of transcription.	0.430
CASP8	TNFAIP3	ENSPPAP00000015206	ENSPPAP00000022449	Caspase 8; Belongs to the peptidase C14A family.	TNF alpha induced protein 3.	0.603
DAB2IP	RIPK1	ENSPPAP00000032187	ENSPPAP00000009086	DAB2 interacting protein.	Receptor interacting serine/threonine kinase 1.	0.540
ENSPPAP00000024044	NLRC3	ENSPPAP00000024044	ENSPPAP00000022446	PPM-type phosphatase domain-containing protein.	NLR family CARD domain containing 3.	0.534
ENSPPAP00000024044	NLRX1	ENSPPAP00000024044	ENSPPAP00000004269	PPM-type phosphatase domain-containing protein.	NLR family member X1.	0.457
ENSPPAP00000024044	PPM1B	ENSPPAP00000024044	ENSPPAP00000042176	PPM-type phosphatase domain-containing protein.	Protein phosphatase, Mg2+/Mn2+ dependent 1B.	0.606
ENSPPAP00000024044	PPM1N	ENSPPAP00000024044	ENSPPAP00000014645	PPM-type phosphatase domain-containing protein.	PP2C_C domain-containing protein.	0.506
ESR1	ABL1	ENSPPAP00000006837	ENSPPAP00000026444	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Tyrosine-protein kinase.	0.419
ESR1	CASP8	ENSPPAP00000006837	ENSPPAP00000015206	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Caspase 8; Belongs to the peptidase C14A family.	0.533