STRINGSTRING
NOD2 NOD2 HTR2A HTR2A FZD5 FZD5 EGF EGF TRAF2 TRAF2 ENSPPAP00000002689 ENSPPAP00000002689 PDGFA PDGFA FLT3 FLT3 HTR2B HTR2B TNF TNF TENM1 TENM1 P2RX7 P2RX7 THBS1 THBS1 TAOK3 TAOK3 ENSPPAP00000004806 ENSPPAP00000004806 ENSPPAP00000004994 ENSPPAP00000004994 TNFRSF11A TNFRSF11A LOC100987247 LOC100987247 ARHGEF5 ARHGEF5 MAP4K2 MAP4K2 WNT5A WNT5A PTPN1 PTPN1 TAB1 TAB1 MAP3K7 MAP3K7 TPD52L1 TPD52L1 CD24 CD24 INSR INSR S100A12 S100A12 CSK CSK AGER AGER HRAS HRAS MAP3K11 MAP3K11 LOC100968595 LOC100968595 RPS3 RPS3 PDGFB PDGFB DUSP19 DUSP19 SASH1 SASH1 EDN1 EDN1 ENSPPAP00000014225 ENSPPAP00000014225 ADAM9 ADAM9 TDGF1 TDGF1 ENSPPAP00000015671 ENSPPAP00000015671 ERN1 ERN1 AXIN1 AXIN1 TLR4 TLR4 DVL2 DVL2 ENSPPAP00000016342 ENSPPAP00000016342 FGFR1 FGFR1 KITLG KITLG ENSPPAP00000016729 ENSPPAP00000016729 MST1R MST1R EZH2 EZH2 AJUBA AJUBA TGFB1 TGFB1 MIF MIF LOC100970329 LOC100970329 PDCD10 PDCD10 KIT KIT CCL19 CCL19 FLT1 FLT1 FGD2 FGD2 MAP3K13 MAP3K13 ENSPPAP00000020965 ENSPPAP00000020965 PDGFD PDGFD PTPRC PTPRC DKK1 DKK1 ROR2 ROR2 ENSPPAP00000022875 ENSPPAP00000022875 NEK10 NEK10 TNFSF11 TNFSF11 ROBO1 ROBO1 EDN3 EDN3 PIK3R5 PIK3R5 GHR GHR PLA2G1B PLA2G1B MAP2K5 MAP2K5 ERN2 ERN2 MAP2K6 MAP2K6 PDGFRB PDGFRB MAGED1 MAGED1 SYK SYK MAP3K4 MAP3K4 PTK2B PTK2B PSEN1 PSEN1 DAB2IP DAB2IP PDGFC PDGFC MAP2K7 MAP2K7 RASGRP1 RASGRP1 MEF2C MEF2C ENSPPAP00000033446 ENSPPAP00000033446 CD40 CD40 FZD4 FZD4 AKAP13 AKAP13 IRAK1 IRAK1 IL1B IL1B MAP3K5 MAP3K5 MAP3K12 MAP3K12 SRC SRC ENSPPAP00000036018 ENSPPAP00000036018 FGF1 FGF1 LRRK2 LRRK2 PDE5A PDE5A ERBB2 ERBB2 LOC100971425 LOC100971425 ERP29 ERP29 FGF2 FGF2 DVL3 DVL3 NTRK3 NTRK3 PAK1 PAK1 TRAF6 TRAF6 PIK3CG PIK3CG TGFA TGFA NOX4 NOX4 NTF3 NTF3 ADAM8 ADAM8 IL34 IL34 EPGN EPGN FGF18 FGF18 MAP3K10 MAP3K10 EPHA4 EPHA4 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
ENSPPAP00000002689CFC domain-containing protein. (158 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (227 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (978 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
THBS1Thrombospondin 1. (1173 aa)
TAOK3TAO kinase 3. (898 aa)
ENSPPAP00000004806Uncharacterized protein. (142 aa)
ENSPPAP00000004994TNF receptor-associated factor. (475 aa)
TNFRSF11ATNF receptor superfamily member 11a. (615 aa)
LOC100987247CFC domain-containing protein. (170 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1597 aa)
MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (794 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TPD52L1TPD52 like 1. (209 aa)
CD24CD24 molecule. (129 aa)
INSRTyrosine-protein kinase receptor. (1362 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
CSKTyrosine-protein kinase. (450 aa)
AGERAdvanced glycosylation end-product specific receptor. (420 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase 11. (833 aa)
LOC100968595Uncharacterized protein. (860 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (217 aa)
SASH1SAM and SH3 domain containing 1. (1251 aa)
EDN1Endothelin 1. (212 aa)
ENSPPAP00000014225Protein kinase domain-containing protein. (433 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
ENSPPAP00000015671Protein kinase domain-containing protein. (414 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
AXIN1Axin 1. (862 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
ENSPPAP00000016342CFC domain-containing protein. (142 aa)
FGFR1Fibroblast growth factor receptor. (812 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
ENSPPAP00000016729Ribosomal_S3_C domain-containing protein. (100 aa)
MST1RMacrophage stimulating 1 receptor. (1400 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
AJUBAAjuba LIM protein. (538 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
LOC100970329Peptidase S1 domain-containing protein. (145 aa)
PDCD10Programmed cell death 10. (212 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
CCL19C-C motif chemokine. (98 aa)
FLT1Uncharacterized protein. (736 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (639 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (986 aa)
ENSPPAP00000020965KH type-2 domain-containing protein. (250 aa)
PDGFDPlatelet derived growth factor D. (329 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1261 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (289 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (982 aa)
ENSPPAP00000022875Uncharacterized protein. (107 aa)
NEK10Protein kinase domain-containing protein. (1173 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
EDN3Endothelin 3. (238 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (883 aa)
GHRGrowth hormone receptor. (641 aa)
PLA2G1BPhospholipase A(2). (148 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (926 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
MAGED1MAGE family member D1. (834 aa)
SYKTyrosine-protein kinase. (635 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1597 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
DAB2IPDAB2 interacting protein. (1155 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (408 aa)
RASGRP1RAS guanyl releasing protein 1. (843 aa)
MEF2CMyocyte enhancer factor 2C. (482 aa)
ENSPPAP00000033446KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (253 aa)
CD40CD40 molecule. (277 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
AKAP13A-kinase anchoring protein 13. (2813 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1356 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
SRCTyrosine-protein kinase. (458 aa)
ENSPPAP00000036018Uncharacterized protein. (240 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
PDE5APhosphodiesterase. (875 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
LOC100971425Uncharacterized protein. (217 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (260 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
PAK1Non-specific serine/threonine protein kinase. (532 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
TGFATransforming growth factor alpha. (181 aa)
NOX4Ferric oxidoreductase domain-containing protein. (285 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
ADAM8ADAM metallopeptidase domain 8. (816 aa)
IL34Interleukin 34. (242 aa)
EPGNUncharacterized protein. (85 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase 10. (793 aa)
EPHA4EPH receptor A4. (986 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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