STRINGSTRING
ENSPPAP00000031014 ENSPPAP00000031014 TRIM2 TRIM2 HDGF HDGF PSEN1 PSEN1 MCL1 MCL1 VEGFB VEGFB LGMN LGMN WFS1 WFS1 MAP2K7 MAP2K7 NR3C1 NR3C1 ARRB2 ARRB2 NEFL NEFL ATF4 ATF4 MEF2C MEF2C SIX1 SIX1 LANCL1 LANCL1 BBC3 BBC3 NGF NGF BAX BAX FGF8 FGF8 NAIP NAIP GPI GPI CLN8 CLN8 CNTF CNTF VSTM2L VSTM2L SIX4 SIX4 CDV3 CDV3 G6PD G6PD PINK1 PINK1 KCNB1 KCNB1 PRKCG PRKCG EPHA7 EPHA7 LOC100983911 LOC100983911 PLA2G3 PLA2G3 TERT TERT BDNF BDNF GRID2 GRID2 SEMA3E SEMA3E VPS54 VPS54 TP53 TP53 MAP3K11 MAP3K11 HIF1A HIF1A CASP2 CASP2 HRAS HRAS FBXW9 FBXW9 FZD9 FZD9 FASLG FASLG PIK3CA PIK3CA IL18 IL18 MAP2K4 MAP2K4 ATM ATM ATF2 ATF2 SLC1A1 SLC1A1 SOD1 SOD1 GATA3 GATA3 NFATC4 NFATC4 ENSPPAP00000006569 ENSPPAP00000006569 SNCA SNCA MDK MDK NTF4 NTF4 DNAJC5 DNAJC5 OXR1 OXR1 LOC100980724 LOC100980724 NDNF NDNF IL6ST IL6ST JAK2 JAK2 GDF5 GDF5 EGLN3 EGLN3 TNF TNF FOXB1 FOXB1 GDNF GDNF STXBP1 STXBP1 ENSPPAP00000002562 ENSPPAP00000002562 BHLHB9 BHLHB9 HYOU1 HYOU1 PRNP PRNP THAP11 THAP11 STAMBP STAMBP PLXND1 PLXND1 BTG2 BTG2 PITX3 PITX3 SRPK2 SRPK2 NRP1 NRP1 KIF14 KIF14 BCL2L1 BCL2L1 ROCK1 ROCK1 XRCC4 XRCC4 AARS1 AARS1 BCL2L11 BCL2L11 PPT1 PPT1 MAP3K12 MAP3K12 MT3 MT3 PARP1 PARP1 TREM2 TREM2 CNTFR CNTFR MYBL2 MYBL2 SLC30A10 SLC30A10 LOC100975187 LOC100975187 ALKBH1 ALKBH1 CRLF1 CRLF1 GABRB2 GABRB2 GBE1 GBE1 NAE1 NAE1 TOX3 TOX3 GCLM GCLM RAPSN RAPSN PTPRZ1 PTPRZ1 NSMF NSMF DNAJC5B DNAJC5B KDR KDR BOK BOK FAIM2 FAIM2 HIPK2 HIPK2 TFAP2A TFAP2A CASP9 CASP9 NTF3 NTF3 ADAM8 ADAM8 GRM4 GRM4 PAWR PAWR CDC34 CDC34 CHL1 CHL1 AKT1S1 AKT1S1 PARK7 PARK7 NF1 NF1 TGFB2 TGFB2 CPEB4 CPEB4 MTNR1B MTNR1B CDK5R1 CDK5R1 TFAP2B TFAP2B ENSPPAP00000016404 ENSPPAP00000016404 FGF20 FGF20 BARHL1 BARHL1 RASA1 RASA1 MAG MAG CORO1A CORO1A TGFB3 TGFB3 NR4A2 NR4A2 DLX1 DLX1 BCL2 BCL2 NRBP2 NRBP2 ADORA2A ADORA2A PCSK9 PCSK9 BIRC5 BIRC5 UBE2M UBE2M AIFM1 AIFM1 NONO NONO ENSPPAP00000019064 ENSPPAP00000019064 LIG4 LIG4 NUPR1 NUPR1 CCL2 CCL2 HSP90AB1 HSP90AB1 XRCC2 XRCC2 GRN GRN EGLN2 EGLN2 NQO1 NQO1 CX3CR1 CX3CR1 ENSPPAP00000020911 ENSPPAP00000020911 MECP2 MECP2 PRKCI PRKCI ISL1 ISL1 MSH2 MSH2 DDIT3 DDIT3 AMBRA1 AMBRA1 LOC100982269 LOC100982269 NTRK1 NTRK1 PRKN PRKN PPARGC1A PPARGC1A ENSPPAP00000023305 ENSPPAP00000023305 AGAP2 AGAP2 CDK5 CDK5 F2R F2R KDM2B KDM2B FBXW7 FBXW7 GCLC GCLC SARM1 SARM1 ENSPPAP00000024328 ENSPPAP00000024328 UNC5B UNC5B ERBB3 ERBB3 CTNNB1 CTNNB1 DRAXIN DRAXIN CLCF1 CLCF1 SNCB SNCB ZPR1 ZPR1 GRIK5 GRIK5 ADNP ADNP ITGA1 ITGA1 RETREG1 RETREG1 BRAF BRAF HMOX1 HMOX1 NES NES ASCL1 ASCL1 ABL1 ABL1 ANGPT1 ANGPT1 ENSPPAP00000026571 ENSPPAP00000026571 SYNGAP1 SYNGAP1 CX3CL1 CX3CL1 ENSPPAP00000026998 ENSPPAP00000026998 GSK3A GSK3A SIGMAR1 SIGMAR1 GRIK2 GRIK2 SNX6 SNX6 IL27RA IL27RA ITGAM ITGAM GABRA5 GABRA5 ENSPPAP00000028661 ENSPPAP00000028661 CITED1 CITED1 AXL AXL NTRK2 NTRK2 ENSPPAP00000029607 ENSPPAP00000029607 BACE1 BACE1 PTK2B PTK2B GFRAL GFRAL ENSPPAP00000030502 ENSPPAP00000030502 TFAP2D TFAP2D SOD2 SOD2 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPPAP00000031014Protein kinase domain-containing protein. (371 aa)
TRIM2Tripartite motif containing 2. (771 aa)
HDGFHeparin binding growth factor. (256 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (186 aa)
LGMNLegumain. (433 aa)
WFS1Wolframin ER transmembrane glycoprotein. (890 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (408 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (777 aa)
ARRB2Arrestin beta 2. (447 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (543 aa)
ATF4Activating transcription factor 4. (340 aa)
MEF2CMyocyte enhancer factor 2C. (482 aa)
SIX1SIX homeobox 1. (284 aa)
LANCL1LanC like 1. (399 aa)
BBC3Uncharacterized protein. (131 aa)
NGFNGF domain-containing protein; Belongs to the NGF-beta family. (123 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
NAIPNLR family apoptosis inhibitory protein. (1403 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (625 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (286 aa)
CNTFCiliary neurotrophic factor. (200 aa)
VSTM2LV-set and transmembrane domain containing 2 like. (202 aa)
SIX4SIX homeobox 4. (775 aa)
CDV3Uncharacterized protein. (156 aa)
G6PDGlucose-6-phosphate dehydrogenase. (560 aa)
PINK1PTEN induced kinase 1. (554 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
EPHA7EPH receptor A7. (974 aa)
LOC100983911BZIP domain-containing protein. (318 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1040 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
VPS54VPS54 subunit of GARP complex. (976 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase 11. (833 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (517 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SLC1A1Amino acid transporter. (524 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
GATA3GATA binding protein 3. (444 aa)
NFATC4Nuclear factor of activated T cells 4. (963 aa)
ENSPPAP00000006569Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (141 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
MDKMidkine. (143 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
DNAJC5DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
OXR1Oxidation resistance 1. (872 aa)
LOC100980724BZIP domain-containing protein. (359 aa)
NDNFNeuron derived neurotrophic factor. (568 aa)
IL6STInterleukin 6 signal transducer. (928 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
GDF5Growth differentiation factor 5. (501 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FOXB1Forkhead box B1. (325 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (594 aa)
ENSPPAP00000002562BZIP domain-containing protein. (314 aa)
BHLHB9Arm_2 domain-containing protein. (547 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
PRNPMajor prion protein; Belongs to the prion family. (253 aa)
THAP11THAP domain containing 11. (309 aa)
STAMBPSTAM binding protein. (424 aa)
PLXND1Uncharacterized protein. (52 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
PITX3Homeobox protein. (208 aa)
SRPK2SRSF protein kinase 2. (687 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1648 aa)
BCL2L1BCL2 like 1. (233 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
PPT1Palmitoyl-protein thioesterase 1. (335 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
MT3Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
CNTFRCiliary neurotrophic factor receptor. (372 aa)
MYBL2MYB proto-oncogene like 2. (700 aa)
SLC30A10Solute carrier family 30 member 10. (458 aa)
LOC100975187Uncharacterized protein. (446 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
CRLF1Cytokine receptor like factor 1. (364 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
GBE11,4-alpha-glucan branching enzyme 1. (702 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (533 aa)
TOX3TOX high mobility group box family member 3. (589 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (232 aa)
RAPSNReceptor associated protein of the synapse. (412 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2316 aa)
NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor. (528 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa)
HIPK2Protein kinase domain-containing protein. (954 aa)
TFAP2ATF_AP-2 domain-containing protein. (328 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
ADAM8ADAM metallopeptidase domain 8. (816 aa)
GRM4Glutamate metabotropic receptor 4. (912 aa)
PAWRPro-apoptotic WT1 regulator. (320 aa)
CDC34Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (233 aa)
CHL1Cell adhesion molecule L1 like. (1225 aa)
AKT1S1AKT1 substrate 1. (276 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
NF1Neurofibromin 1. (2839 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (729 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (362 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (351 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
ENSPPAP00000016404Uncharacterized protein. (397 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
BARHL1BarH like homeobox 1. (376 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
MAGMyelin associated glycoprotein. (626 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
DLX1Distal-less homeobox 1. (255 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
NRBP2Nuclear receptor binding protein 2. (501 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (692 aa)
BIRC5Baculoviral IAP repeat containing 5. (165 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (177 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
NONONon-POU domain containing octamer binding. (471 aa)
ENSPPAP00000019064Protein kinase domain-containing protein. (201 aa)
LIG4DNA ligase. (911 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
CCL2C-C motif chemokine. (99 aa)
HSP90AB1HATPase_c domain-containing protein. (688 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
GRNGranulin precursor. (593 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (407 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (277 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
ENSPPAP00000020911J domain-containing protein. (148 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (493 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
ISL1ISL LIM homeobox 1. (349 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
LOC100982269Uncharacterized protein. (390 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (428 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
ENSPPAP00000023305DJ-1_PfpI domain-containing protein. (168 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1021 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
KDM2BLysine demethylase 2B. (1336 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
SARM1Sterile alpha and TIR motif containing 1. (724 aa)
ENSPPAP00000024328Protein kinase domain-containing protein. (212 aa)
UNC5BUnc-5 netrin receptor B. (945 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1344 aa)
CTNNB1Catenin beta 1. (781 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
CLCF1Uncharacterized protein. (322 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (134 aa)
ZPR1ZPR1 zinc finger. (459 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (980 aa)
ADNPActivity dependent neuroprotector homeobox. (1102 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
RETREG1Uncharacterized protein. (356 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
NESNestin; Belongs to the intermediate filament family. (1620 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ANGPT1Angiopoietin 1. (498 aa)
ENSPPAP00000026571Uncharacterized protein. (67 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1346 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
ENSPPAP00000026998Uncharacterized protein. (493 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (463 aa)
SIGMAR1Uncharacterized protein. (134 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (869 aa)
SNX6Sorting nexin; Involved in several stages of intracellular trafficking. (416 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
ENSPPAP00000028661Protein kinase C. (574 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
ENSPPAP00000029607Uncharacterized protein. (252 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
GFRALGDNF family receptor alpha like. (394 aa)
ENSPPAP00000030502Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (849 aa)
TFAP2DTranscription factor AP-2 delta. (452 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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