(18 nodes) Autophagy of nucleus network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPPAP00000042332	Uncharacterized protein. (349 aa)
	ULK1	Protein kinase domain-containing protein. (1408 aa)
	WIPI1	WD repeat domain, phosphoinositide interacting 1. (455 aa)
	ATG13	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
	WDR45	WD repeat domain 45. (361 aa)
	ATG3	Uncharacterized protein. (158 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
	RB1CC1	RB1 inducible coiled-coil 1. (1594 aa)
	ATG2B	Autophagy related 2B. (2073 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (181 aa)
	WIPI2	WD repeat domain, phosphoinositide interacting 2. (454 aa)
	ATG2A	Autophagy related 2A. (1938 aa)
	WDR45B	Uncharacterized protein. (338 aa)
	ULK2	Unc-51 like autophagy activating kinase 2. (1007 aa)
	ATG9B	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (826 aa)
	ATG9A	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (848 aa)
	ENSPPAP00000023423	Autophagy_N domain-containing protein. (120 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG13	ENSPPAP00000028112	ENSPPAP00000039127	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	0.674
ATG12	ATG2A	ENSPPAP00000028112	ENSPPAP00000007381	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 2A.	0.457
ATG12	ATG2B	ENSPPAP00000028112	ENSPPAP00000028517	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 2B.	0.461
ATG12	ATG3	ENSPPAP00000028112	ENSPPAP00000037275	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Uncharacterized protein.	0.989
ATG12	ATG5	ENSPPAP00000028112	ENSPPAP00000035390	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	ATG7	ENSPPAP00000028112	ENSPPAP00000035158	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.993
ATG12	ATG9A	ENSPPAP00000028112	ENSPPAP00000024107	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.551
ATG12	ATG9B	ENSPPAP00000028112	ENSPPAP00000025845	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.537
ATG12	ENSPPAP00000023423	ENSPPAP00000028112	ENSPPAP00000023423	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy_N domain-containing protein.	0.978
ATG12	RB1CC1	ENSPPAP00000028112	ENSPPAP00000034694	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	RB1 inducible coiled-coil 1.	0.820
ATG12	ULK1	ENSPPAP00000028112	ENSPPAP00000040908	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Protein kinase domain-containing protein.	0.922
ATG12	ULK2	ENSPPAP00000028112	ENSPPAP00000027976	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Unc-51 like autophagy activating kinase 2.	0.847
ATG12	WIPI1	ENSPPAP00000028112	ENSPPAP00000039139	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	WD repeat domain, phosphoinositide interacting 1.	0.931
ATG12	WIPI2	ENSPPAP00000028112	ENSPPAP00000023759	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	WD repeat domain, phosphoinositide interacting 2.	0.958
ATG13	ATG12	ENSPPAP00000039127	ENSPPAP00000028112	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.674
ATG13	ATG2A	ENSPPAP00000039127	ENSPPAP00000007381	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Autophagy related 2A.	0.509
ATG13	ATG2B	ENSPPAP00000039127	ENSPPAP00000028517	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Autophagy related 2B.	0.414
ATG13	ATG3	ENSPPAP00000039127	ENSPPAP00000037275	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Uncharacterized protein.	0.536
ATG13	ATG5	ENSPPAP00000039127	ENSPPAP00000035390	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.717
ATG13	ATG7	ENSPPAP00000039127	ENSPPAP00000035158	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.585