(34 nodes) mRNA cis splicing, via spliceosome network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPPAP00000004556	Uncharacterized protein. (129 aa)
	ENSPPAP00000007658	Uncharacterized protein. (191 aa)
	ENSPPAP00000008868	Uncharacterized protein. (66 aa)
	PRPF39	Pre-mRNA processing factor 39. (669 aa)
	CACTIN	Cactin, spliceosome C complex subunit. (710 aa)
	PRPF40B	Pre-mRNA processing factor 40 homolog B. (891 aa)
	ENSPPAP00000014042	PWWP domain-containing protein. (311 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (800 aa)
	PSIP1	PC4 and SFRS1 interacting protein 1. (530 aa)
	DCPS	Decapping enzyme, scavenger. (337 aa)
	DNAJC8	DnaJ heat shock protein family (Hsp40) member C8. (253 aa)
	RBM17	RNA binding motif protein 17. (401 aa)
	CWC15	CWC15 spliceosome associated protein homolog. (229 aa)
	ENSPPAP00000021965	J domain-containing protein. (196 aa)
	RBM22	RNA binding motif protein 22. (423 aa)
	WBP4	WW domain binding protein 4. (376 aa)
	ENSPPAP00000024474	Uncharacterized protein. (137 aa)
	CLNS1A	Chloride nucleotide-sensitive channel 1A. (237 aa)
	SFSWAP	Splicing factor SWAP. (1003 aa)
	NCBP2	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (138 aa)
	DDX23	DEAD-box helicase 23. (820 aa)
	ENSPPAP00000031087	RRM_1 domain-containing protein. (107 aa)
	ENSPPAP00000031761	Uncharacterized protein; Belongs to the DEAD box helicase family. (720 aa)
	ENSPPAP00000032966	J domain-containing protein. (243 aa)
	PRPF40A	Pre-mRNA processing factor 40 homolog A. (941 aa)
	PRPF4B	Pre-mRNA processing factor 4B. (1007 aa)
	WBP11	Uncharacterized protein. (641 aa)
	ENSPPAP00000037569	Uncharacterized protein. (134 aa)
	SRSF12	Serine and arginine rich splicing factor 12. (264 aa)
	SNRNP200	Small nuclear ribonucleoprotein U5 subunit 200. (2136 aa)
	SF3A1	Splicing factor 3a subunit 1. (793 aa)
	ENSPPAP00000040276	Uncharacterized protein. (204 aa)
	SRSF1	Uncharacterized protein. (253 aa)
	SNRPC	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (159 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACTIN	CWC15	ENSPPAP00000009948	ENSPPAP00000020763	Cactin, spliceosome C complex subunit.	CWC15 spliceosome associated protein homolog.	0.758
CACTIN	RBM22	ENSPPAP00000009948	ENSPPAP00000022564	Cactin, spliceosome C complex subunit.	RNA binding motif protein 22.	0.758
CACTIN	SNRNP200	ENSPPAP00000009948	ENSPPAP00000037836	Cactin, spliceosome C complex subunit.	Small nuclear ribonucleoprotein U5 subunit 200.	0.766
CWC15	CACTIN	ENSPPAP00000020763	ENSPPAP00000009948	CWC15 spliceosome associated protein homolog.	Cactin, spliceosome C complex subunit.	0.758
CWC15	ENSPPAP00000004556	ENSPPAP00000020763	ENSPPAP00000004556	CWC15 spliceosome associated protein homolog.	Uncharacterized protein.	0.858
CWC15	ENSPPAP00000024474	ENSPPAP00000020763	ENSPPAP00000024474	CWC15 spliceosome associated protein homolog.	Uncharacterized protein.	0.858
CWC15	ENSPPAP00000031087	ENSPPAP00000020763	ENSPPAP00000031087	CWC15 spliceosome associated protein homolog.	RRM_1 domain-containing protein.	0.712
CWC15	ENSPPAP00000040276	ENSPPAP00000020763	ENSPPAP00000040276	CWC15 spliceosome associated protein homolog.	Uncharacterized protein.	0.814
CWC15	NCBP2	ENSPPAP00000020763	ENSPPAP00000027432	CWC15 spliceosome associated protein homolog.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.779
CWC15	RBM17	ENSPPAP00000020763	ENSPPAP00000018508	CWC15 spliceosome associated protein homolog.	RNA binding motif protein 17.	0.750
CWC15	RBM22	ENSPPAP00000020763	ENSPPAP00000022564	CWC15 spliceosome associated protein homolog.	RNA binding motif protein 22.	0.955
CWC15	SF3A1	ENSPPAP00000020763	ENSPPAP00000038213	CWC15 spliceosome associated protein homolog.	Splicing factor 3a subunit 1.	0.869
CWC15	SNRNP200	ENSPPAP00000020763	ENSPPAP00000037836	CWC15 spliceosome associated protein homolog.	Small nuclear ribonucleoprotein U5 subunit 200.	0.853
CWC15	SRSF1	ENSPPAP00000020763	ENSPPAP00000041588	CWC15 spliceosome associated protein homolog.	Uncharacterized protein.	0.772
CWC15	WBP11	ENSPPAP00000020763	ENSPPAP00000035960	CWC15 spliceosome associated protein homolog.	Uncharacterized protein.	0.858
DDX23	NCBP2	ENSPPAP00000029696	ENSPPAP00000027432	DEAD-box helicase 23.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.443
DDX23	PRPF39	ENSPPAP00000029696	ENSPPAP00000008940	DEAD-box helicase 23.	Pre-mRNA processing factor 39.	0.563
DDX23	PRPF4B	ENSPPAP00000029696	ENSPPAP00000034677	DEAD-box helicase 23.	Pre-mRNA processing factor 4B.	0.881
DDX23	SART1	ENSPPAP00000029696	ENSPPAP00000014256	DEAD-box helicase 23.	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP.	0.957
DDX23	SF3A1	ENSPPAP00000029696	ENSPPAP00000038213	DEAD-box helicase 23.	Splicing factor 3a subunit 1.	0.852