STRINGSTRING
ITGAV ITGAV ANXA11 ANXA11 ENSPPAP00000025599 ENSPPAP00000025599 MCOLN1 MCOLN1 SLC11A1 SLC11A1 LAMP1 LAMP1 PIP4P2 PIP4P2 ATP6V0A1 ATP6V0A1 AMBRA1 AMBRA1 HVCN1 HVCN1 ENSPPAP00000021549 ENSPPAP00000021549 ENSPPAP00000021390 ENSPPAP00000021390 STX4 STX4 ANXA3 ANXA3 Papa-A Papa-A RAB20 RAB20 LOC100993063 LOC100993063 GSN GSN ATP6V0D2 ATP6V0D2 VAMP7 VAMP7 ATP6V0E2 ATP6V0E2 WAS WAS SNX3 SNX3 ATP6V0A4 ATP6V0A4 LOC100993131 LOC100993131 LOC100970329 LOC100970329 RAB14 RAB14 STXBP3 STXBP3 NCF1 NCF1 CORO1A CORO1A UNC93B1 UNC93B1 ATG14 ATG14 RAB10 RAB10 ABCA1 ABCA1 RAB11FIP1 RAB11FIP1 VIM VIM ATP6V0D1 ATP6V0D1 ATP6V0B ATP6V0B MPO MPO RAB9B RAB9B CD36 CD36 DNM2 DNM2 HLA-C HLA-C CALR CALR INPP5B INPP5B ADAM8 ADAM8 RAB39A RAB39A NOD2 NOD2 STX6 STX6 HGS HGS RAB23 RAB23 STXBP1 STXBP1 CLCN3 CLCN3 ATP7A ATP7A PLD4 PLD4 PLA2G5 PLA2G5 LOC100986914 LOC100986914 SYT7 SYT7 APPL2 APPL2 RAB5A RAB5A ATP6V0C ATP6V0C STX12 STX12 SRGAP2 SRGAP2 CLEC4E CLEC4E RAB8A RAB8A ATG5 ATG5 VAMP3 VAMP3 CDC42EP2 CDC42EP2 LOC100986336 LOC100986336 TLR1 TLR1 STXBP4 STXBP4 LTF LTF ITGB5 ITGB5 OCRL OCRL MPEG1 MPEG1 RAB31 RAB31 TAPBP TAPBP RAB9A RAB9A NCF4 NCF4 SCIMP SCIMP RAB43 RAB43 MYO1C MYO1C TLR2 TLR2 SNAP23 SNAP23 VPS26B VPS26B ENSPPAP00000008146 ENSPPAP00000008146 UVRAG UVRAG RILP RILP TLR7 TLR7 KIF5B KIF5B RAB32 RAB32 CYBB CYBB PIP4P1 PIP4P1 NOD1 NOD1 RAB11B RAB11B ZYX ZYX LAMP2 LAMP2 GNLY GNLY RAB11FIP5 RAB11FIP5 ENSPPAP00000012927 ENSPPAP00000012927 HLA-B HLA-B PIK3C3 PIK3C3 TCIRG1 TCIRG1 PIK3R4 PIK3R4 RAB11A RAB11A CTSS CTSS TRIM14 TRIM14 IRGM IRGM FLNB FLNB RAB22A RAB22A RAC2 RAC2 PDIA3 PDIA3 VAMP8 VAMP8 CDC42 CDC42 SLAMF1 SLAMF1 HLA-G HLA-G SYT11 SYT11 STX8 STX8 PIKFYVE PIKFYVE ENSPPAP00000031464 ENSPPAP00000031464 FMNL1 FMNL1 NCF2 NCF2 BECN1 BECN1 APPL1 APPL1 ZDHHC5 ZDHHC5 SYK SYK RAB8B RAB8B ACTG1 ACTG1 RAB7B RAB7B RAB34 RAB34 ATP6V0E1 ATP6V0E1 RAB38 RAB38 ATG12 ATG12 ATP6V0A2 ATP6V0A2 MTOR MTOR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
ANXA11Annexin. (542 aa)
ENSPPAP00000025599Uncharacterized protein. (195 aa)
MCOLN1Mucolipin 1. (580 aa)
SLC11A1Solute carrier family 11 member 1. (550 aa)
LAMP1Lysosomal associated membrane protein 1. (465 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (243 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
HVCN1Hydrogen voltage gated channel 1. (274 aa)
ENSPPAP00000021549Uncharacterized protein. (160 aa)
ENSPPAP00000021390IGc1 domain-containing protein; Belongs to the MHC class I family. (351 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (297 aa)
ANXA3Annexin. (323 aa)
Papa-AIGc1 domain-containing protein; Belongs to the MHC class I family. (406 aa)
RAB20RAB20, member RAS oncogene family. (234 aa)
LOC100993063MACPF domain-containing protein. (701 aa)
GSNGelsolin. (784 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (260 aa)
ATP6V0E2ATPase H+ transporting V0 subunit e2. (213 aa)
WASWASP actin nucleation promoting factor. (502 aa)
SNX3Sorting nexin 3. (162 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (782 aa)
LOC100993131Cell division control protein 42 homolog. (191 aa)
LOC100970329Peptidase S1 domain-containing protein. (145 aa)
RAB14RAB14, member RAS oncogene family. (212 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (524 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (561 aa)
ATG14Autophagy related 14. (492 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
ABCA1ATP binding cassette subfamily A member 1. (2264 aa)
RAB11FIP1RAB11 family interacting protein 1. (1159 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (392 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (261 aa)
MPOMyeloperoxidase. (745 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (785 aa)
HLA-CMajor histocompatibility complex, class I, C; Belongs to the MHC class I family. (397 aa)
CALRCalreticulin. (417 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (997 aa)
ADAM8ADAM metallopeptidase domain 8. (816 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
STX6Syntaxin 6; Belongs to the syntaxin family. (255 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
RAB23RAB23, member RAS oncogene family. (237 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (594 aa)
CLCN3Chloride channel protein. (811 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
PLD4Phospholipase D family member 4. (515 aa)
PLA2G5Phospholipase A(2). (138 aa)
LOC100986914Uncharacterized protein. (210 aa)
SYT7Uncharacterized protein. (686 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (647 aa)
RAB5ARAB5A, member RAS oncogene family. (216 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
SRGAP2SLIT-ROBO Rho GTPase activating protein 2. (1071 aa)
CLEC4EC-type lectin domain-containing protein. (174 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (116 aa)
CDC42EP2Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (210 aa)
LOC100986336TIR domain-containing protein. (1033 aa)
TLR1Toll-like receptor. (786 aa)
STXBP4Syntaxin binding protein 4. (553 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (803 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (887 aa)
MPEG1Macrophage expressed 1. (716 aa)
RAB31RAB31, member RAS oncogene family. (183 aa)
TAPBPTAP binding protein. (466 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
NCF4Uncharacterized protein. (368 aa)
SCIMPSLP adaptor and CSK interacting membrane protein. (144 aa)
RAB43RAB43, member RAS oncogene family. (212 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
VPS26BVPS26, retromer complex component B. (336 aa)
ENSPPAP00000008146Uncharacterized protein. (93 aa)
UVRAGUV radiation resistance associated. (698 aa)
RILPUncharacterized protein. (348 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
RAB32RAB32, member RAS oncogene family. (220 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
RAB11BUncharacterized protein. (221 aa)
ZYXZyxin. (569 aa)
LAMP2Lysosomal associated membrane protein 2. (411 aa)
GNLYGranulysin. (173 aa)
RAB11FIP5FIP-RBD domain-containing protein. (1181 aa)
ENSPPAP00000012927Uncharacterized protein; Belongs to the actin family. (336 aa)
HLA-BIg-like domain-containing protein; Belongs to the MHC class I family. (384 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
RAB11ARAB11A, member RAS oncogene family. (216 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (331 aa)
TRIM14Tripartite motif containing 14. (442 aa)
IRGMImmunity related GTPase M. (195 aa)
FLNBFilamin B. (2633 aa)
RAB22ARAB22A, member RAS oncogene family. (194 aa)
RAC2Rac family small GTPase 2. (192 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
CDC42Uncharacterized protein. (191 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (356 aa)
HLA-GMajor histocompatibility complex, class I, G; Belongs to the MHC class I family. (355 aa)
SYT11Synaptotagmin 11. (431 aa)
STX8Syntaxin 8. (236 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
ENSPPAP00000031464Thioredoxin domain-containing protein. (484 aa)
FMNL1Formin like 1. (1018 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
BECN1Beclin 1. (450 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
ZDHHC5Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (715 aa)
SYKTyrosine-protein kinase. (635 aa)
RAB8BRAB8B, member RAS oncogene family. (207 aa)
ACTG1Actin gamma 1. (375 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
RAB34RAB34, member RAS oncogene family. (268 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
RAB38RAB38, member RAS oncogene family. (211 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (181 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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