(43 nodes) Regulation of T-helper cell differentiation network (Pan paniscus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	ZC3H12A	Zinc finger CCCH-type containing 12A. (599 aa)
	JAK3	Tyrosine-protein kinase. (1090 aa)
	CD80	CD80 molecule. (288 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1134 aa)
	NFKBID	ANK_REP_REGION domain-containing protein. (465 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (125 aa)
	MALT1	MALT1 paracaspase. (786 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1191 aa)
	ZBTB7B	Zinc finger and BTB domain containing 7B. (573 aa)
	IL12RB1	Interleukin 12 receptor subunit beta 1. (662 aa)
	NFKBIZ	NFKB inhibitor zeta. (706 aa)
	TBX21	T-box transcription factor 21. (494 aa)
	ENSPPAP00000021246	SOCS box domain-containing protein. (478 aa)
	CD86	CD86 molecule. (329 aa)
	SHB	SH2 domain-containing protein. (285 aa)
	CCL19	C-C motif chemokine. (98 aa)
	IL27	Uncharacterized protein. (154 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	MYB	MYB proto-oncogene, transcription factor. (768 aa)
	HLX	H2.0 like homeobox. (493 aa)
	SMAD7	MH2 domain-containing protein. (211 aa)
	ANXA1	Annexin. (346 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	FOXP3	Forkhead box P3. (441 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
	GATA3	GATA binding protein 3. (444 aa)
	JUNB	JunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
	IL23R	Interleukin 23 receptor. (629 aa)
	LOXL3	Lysyl oxidase like 3. (753 aa)
	ENSPPAP00000004517	Uncharacterized protein. (654 aa)
	NLRP3	NLR family pyrin domain containing 3. (1036 aa)
	TNFSF18	TNF superfamily member 18. (199 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
	RARA	Uncharacterized protein. (609 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
	IL4R	Interleukin 4 receptor. (873 aa)
	IRF4	Interferon regulatory factor 4. (392 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BATF	BCL6	ENSPPAP00000030966	ENSPPAP00000011560	Basic leucine zipper ATF-like transcription factor.	BCL6 transcription repressor.	0.703
BATF	FOXP3	ENSPPAP00000030966	ENSPPAP00000009817	Basic leucine zipper ATF-like transcription factor.	Forkhead box P3.	0.503
BATF	GATA3	ENSPPAP00000030966	ENSPPAP00000007588	Basic leucine zipper ATF-like transcription factor.	GATA binding protein 3.	0.538
BATF	IL2	ENSPPAP00000030966	ENSPPAP00000014571	Basic leucine zipper ATF-like transcription factor.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.423
BATF	IL23R	ENSPPAP00000030966	ENSPPAP00000004750	Basic leucine zipper ATF-like transcription factor.	Interleukin 23 receptor.	0.421
BATF	IRF4	ENSPPAP00000030966	ENSPPAP00000036456	Basic leucine zipper ATF-like transcription factor.	Interferon regulatory factor 4.	0.898
BATF	JUNB	ENSPPAP00000030966	ENSPPAP00000006295	Basic leucine zipper ATF-like transcription factor.	JunB proto-oncogene, AP-1 transcription factor subunit.	0.974
BATF	TBX21	ENSPPAP00000030966	ENSPPAP00000021535	Basic leucine zipper ATF-like transcription factor.	T-box transcription factor 21.	0.598
BCL6	BATF	ENSPPAP00000011560	ENSPPAP00000030966	BCL6 transcription repressor.	Basic leucine zipper ATF-like transcription factor.	0.703
BCL6	CD80	ENSPPAP00000011560	ENSPPAP00000033006	BCL6 transcription repressor.	CD80 molecule.	0.416
BCL6	CD86	ENSPPAP00000011560	ENSPPAP00000021183	BCL6 transcription repressor.	CD86 molecule.	0.420
BCL6	FOXP3	ENSPPAP00000011560	ENSPPAP00000009817	BCL6 transcription repressor.	Forkhead box P3.	0.596
BCL6	GATA3	ENSPPAP00000011560	ENSPPAP00000007588	BCL6 transcription repressor.	GATA binding protein 3.	0.606
BCL6	IL2	ENSPPAP00000011560	ENSPPAP00000014571	BCL6 transcription repressor.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.520
BCL6	IL4	ENSPPAP00000011560	ENSPPAP00000008567	BCL6 transcription repressor.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.576
BCL6	IRF4	ENSPPAP00000011560	ENSPPAP00000036456	BCL6 transcription repressor.	Interferon regulatory factor 4.	0.816
BCL6	RARA	ENSPPAP00000011560	ENSPPAP00000042640	BCL6 transcription repressor.	Uncharacterized protein.	0.485
BCL6	TBX21	ENSPPAP00000011560	ENSPPAP00000021535	BCL6 transcription repressor.	T-box transcription factor 21.	0.708
CCL19	CD80	ENSPPAP00000020066	ENSPPAP00000033006	C-C motif chemokine.	CD80 molecule.	0.434
CD80	BCL6	ENSPPAP00000033006	ENSPPAP00000011560	CD80 molecule.	BCL6 transcription repressor.	0.416