STRINGSTRING
PLA2G3 PLA2G3 PRKDC PRKDC KAT7 KAT7 ACIN1 ACIN1 MAPK14 MAPK14 IFNG IFNG ENSPPAP00000039636 ENSPPAP00000039636 PPP3CA PPP3CA CSF1 CSF1 CREB1 CREB1 LEF1 LEF1 TRAF6 TRAF6 IL23A IL23A DCSTAMP DCSTAMP IL5 IL5 IL34 IL34 TESC TESC SCIN SCIN ENSPPAP00000042728 ENSPPAP00000042728 ACVR2A ACVR2A HOXA5 HOXA5 TREM2 TREM2 STAT3 STAT3 ARNT ARNT SLC9B2 SLC9B2 OCSTAMP OCSTAMP MED1 MED1 CALCA CALCA MTURN MTURN STAT5B STAT5B STAT1 STAT1 FAXDC2 FAXDC2 TRIB1 TRIB1 ENSPPAP00000031956 ENSPPAP00000031956 ENSPPAP00000031824 ENSPPAP00000031824 NCKAP1L NCKAP1L CD74 CD74 RAB7B RAB7B IL12B IL12B ACVR1B ACVR1B INHBA INHBA NINJ1 NINJ1 SMAP1 SMAP1 PF4 PF4 FES FES POU4F2 POU4F2 PPARGC1B PPARGC1B PRMT1 PRMT1 TNFSF11 TNFSF11 GATA1 GATA1 FADD FADD CD4 CD4 ROR2 ROR2 JAG1 JAG1 ID2 ID2 EVI2B EVI2B KLF10 KLF10 GNAS-2 GNAS-2 TAL1 TAL1 ANKRD54 ANKRD54 CD101 CD101 TMEM64 TMEM64 THPO THPO PRKCA PRKCA TGFB1 TGFB1 KITLG KITLG INPP5D INPP5D PITHD1 PITHD1 CASP8 CASP8 FAM210B FAM210B ISG15 ISG15 NOTCH2 NOTCH2 ABCB10 ABCB10 MPL MPL RCOR1 RCOR1 GPR68 GPR68 ENSPPAP00000001242 ENSPPAP00000001242 RUNX1 RUNX1 RB1 RB1 LIF LIF HCLS1 HCLS1 TNF TNF IL23R IL23R ENSPPAP00000004994 ENSPPAP00000004994 FOS FOS CSF3 CSF3 CCR1 CCR1 RHEX RHEX ETS1 ETS1 ZNF16 ZNF16 ZFP36L1 ZFP36L1 CTNNBIP1 CTNNBIP1 GATA2 GATA2 RIPK1 RIPK1 BRD1 BRD1 HAX1 HAX1 HIF1A HIF1A IL17A IL17A NEDD9 NEDD9 IL20 IL20 HSF1 HSF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLA2G3Phospholipase A2 group III. (509 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
ACIN1Apoptotic chromatin condensation inducer 1. (1339 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ENSPPAP00000039636DUF1279 domain-containing protein. (209 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (549 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (469 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL34Interleukin 34. (242 aa)
TESCTescalcin. (214 aa)
SCINScinderin. (715 aa)
ENSPPAP00000042728Uncharacterized protein. (325 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
HOXA5Homeobox A5. (270 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (548 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1555 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
MTURNUncharacterized protein. (98 aa)
STAT5BSignal transducer and activator of transcription. (789 aa)
STAT1Signal transducer and activator of transcription. (759 aa)
FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (310 aa)
TRIB1Tribbles pseudokinase 1. (371 aa)
ENSPPAP00000031956HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (254 aa)
ENSPPAP00000031824Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (341 aa)
NCKAP1LNCK associated protein 1 like. (1127 aa)
CD74CD74 molecule. (296 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
INHBAInhibin subunit beta A. (426 aa)
NINJ1Ninjurin 1. (141 aa)
SMAP1Small ArfGAP 1. (496 aa)
PF4C-X-C motif chemokine. (101 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa)
POU4F2POU domain protein. (406 aa)
PPARGC1BPPARG coactivator 1 beta. (997 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
GATA1GATA binding protein 1. (413 aa)
FADDDeath domain-containing protein. (144 aa)
CD4CD4 molecule. (458 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (982 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
EVI2BEcotropic viral integration site 2B. (434 aa)
KLF10Kruppel like factor 10. (480 aa)
GNAS-2Uncharacterized protein. (245 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (291 aa)
ANKRD54ANK_REP_REGION domain-containing protein. (180 aa)
CD101CD101 molecule. (1017 aa)
TMEM64Transmembrane protein 64. (320 aa)
THPOThrombopoietin. (353 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
PITHD1PITH domain containing 1. (182 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (496 aa)
FAM210BDUF1279 domain-containing protein. (178 aa)
ISG15ISG15 ubiquitin like modifier. (165 aa)
NOTCH2Notch receptor 2. (2254 aa)
ABCB10ATP binding cassette subfamily B member 10. (609 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (646 aa)
RCOR1Uncharacterized protein. (434 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
ENSPPAP00000001242BHLH domain-containing protein. (117 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
RB1RB transcriptional corepressor 1. (911 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (484 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IL23RInterleukin 23 receptor. (629 aa)
ENSPPAP00000004994TNF receptor-associated factor. (475 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CSF3Colony stimulating factor 3. (204 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
RHEXRegulator of hemoglobinization and erythroid cell expansion. (172 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
ZNF16Zinc finger protein 16; Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis (By similarity). (673 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
GATA2GATA binding protein 2. (480 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (805 aa)
BRD1Bromodomain containing 1. (1189 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
IL17AInterleukin 17A. (155 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
IL20Interleukin 20. (176 aa)
HSF1Heat shock transcription factor 1. (490 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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