STRINGSTRING
RB1 RB1 ENSPPAP00000001242 ENSPPAP00000001242 LIF LIF HCLS1 HCLS1 GATA2 GATA2 RIPK1 RIPK1 C1QC C1QC HSF1 HSF1 CASP8 CASP8 TGFB1 TGFB1 PRKCA PRKCA ID2 ID2 ROR2 ROR2 FADD FADD PF4 PF4 INHBA INHBA PTPN2 PTPN2 TRIB1 TRIB1 CALCA CALCA ZBTB46 ZBTB46 CSF1 CSF1 INHA INHA IL34 IL34 ADIPOQ ADIPOQ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RB1RB transcriptional corepressor 1. (911 aa)
ENSPPAP00000001242BHLH domain-containing protein. (117 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (484 aa)
GATA2GATA binding protein 2. (480 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (805 aa)
C1QCComplement C1q C chain. (245 aa)
HSF1Heat shock transcription factor 1. (490 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (496 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (982 aa)
FADDDeath domain-containing protein. (144 aa)
PF4C-X-C motif chemokine. (101 aa)
INHBAInhibin subunit beta A. (426 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (424 aa)
TRIB1Tribbles pseudokinase 1. (371 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
ZBTB46Zinc finger and BTB domain containing 46. (589 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (549 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
IL34Interleukin 34. (242 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (286 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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