STRINGSTRING
ABRAXAS1 ABRAXAS1 ACTR8 ACTR8 POGZ POGZ FMN2 FMN2 BABAM1 BABAM1 PRKCG PRKCG WDR48 WDR48 FH FH PRKDC PRKDC DHX9 DHX9 ACTR2 ACTR2 NFRKB NFRKB BRCA1 BRCA1 ACTL6A ACTL6A SPIDR SPIDR BRD8 BRD8 NPAS2 NPAS2 YEATS4 YEATS4 ENSPPAP00000018336 ENSPPAP00000018336 WAS WAS PIAS4 PIAS4 RNF8 RNF8 EPC1 EPC1 FANCB FANCB ENSPPAP00000019066 ENSPPAP00000019066 ENSPPAP00000019077 ENSPPAP00000019077 SMARCD1 SMARCD1 ENSPPAP00000019394 ENSPPAP00000019394 PCNA PCNA ENSPPAP00000020965 ENSPPAP00000020965 SIRT6 SIRT6 SPIRE1 SPIRE1 RAD51AP1 RAD51AP1 ACTL6B ACTL6B SMARCC1 SMARCC1 FAM178B FAM178B ENSPPAP00000016729 ENSPPAP00000016729 RNF168 RNF168 EYA4 EYA4 CCDC117 CCDC117 SPIRE2 SPIRE2 SIRT1 SIRT1 DTX3L DTX3L BCL7A BCL7A RBBP8 RBBP8 CEBPG CEBPG RIF1 RIF1 PBRM1 PBRM1 ENSPPAP00000005256 ENSPPAP00000005256 EYA1 EYA1 ENSPPAP00000004806 ENSPPAP00000004806 ENSPPAP00000004466 ENSPPAP00000004466 INO80D INO80D ENSPPAP00000003540 ENSPPAP00000003540 PNKP PNKP MRGBP-2 MRGBP-2 ERCC6 ERCC6 HELQ HELQ SHLD1 SHLD1 PHF10 PHF10 TRIM28 TRIM28 ENSPPAP00000023917 ENSPPAP00000023917 ARID1A ARID1A SMARCD2 SMARCD2 ENSPPAP00000024326 ENSPPAP00000024326 TIMELESS TIMELESS MAD2L2 MAD2L2 UIMC1 UIMC1 ENSPPAP00000025554 ENSPPAP00000025554 ENSPPAP00000026193 ENSPPAP00000026193 ENSPPAP00000027030 ENSPPAP00000027030 TRRAP TRRAP YY1 YY1 DMAP1 DMAP1 ZCWPW1 ZCWPW1 MRNIP MRNIP BCL7B BCL7B OOEP OOEP DPF3 DPF3 ACTB ACTB SMCHD1 SMCHD1 VPS72 VPS72 SMARCE1 SMARCE1 EYA3 EYA3 RUVBL2 RUVBL2 BCL7C BCL7C INO80B INO80B ENSPPAP00000031361 ENSPPAP00000031361 EYA2 EYA2 KMT5B KMT5B BRD7 BRD7 BABAM2 BABAM2 SMARCA2 SMARCA2 SMARCD3 SMARCD3 MRGBP MRGBP FGF10 FGF10 ENSPPAP00000033446 ENSPPAP00000033446 SETMAR SETMAR BRCC3 BRCC3 RUVBL1 RUVBL1 EPC2 EPC2 SLF2 SLF2 MCRS1 MCRS1 PARP3 PARP3 PARP1 PARP1 HDAC10 HDAC10 EP400 EP400 WRAP53 WRAP53 TMEM161A TMEM161A ENSPPAP00000038467 ENSPPAP00000038467 TFPT TFPT KAT5 KAT5 INO80 INO80 ENSPPAP00000039065 ENSPPAP00000039065 MFSD11 MFSD11 DPF1 DPF1 LOC100987671 LOC100987671 FAM168A FAM168A ENSPPAP00000040700 ENSPPAP00000040700 DPF2 DPF2 FOXM1 FOXM1 HDGFL2 HDGFL2 UBE2V2 UBE2V2 PARP9 PARP9 INO80E INO80E KMT5C KMT5C ARID2 ARID2 SMARCA4 SMARCA4 KHDC3L KHDC3L MMS19 MMS19 SLF1 SLF1 EGFR EGFR MGMT MGMT MBTD1 MBTD1 ENSPPAP00000009290 ENSPPAP00000009290 LOC100985819 LOC100985819 UBE2N UBE2N MEAF6 MEAF6 SMARCB1 SMARCB1 SMARCC2 SMARCC2 ENSPPAP00000011209 ENSPPAP00000011209 ING3 ING3 FUS FUS TIGAR TIGAR RPS3 RPS3 UCHL5 UCHL5 ARID1B ARID1B ERCC8 ERCC8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (407 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
POGZPogo transposable element derived with ZNF domain. (1410 aa)
FMN2Uncharacterized protein. (42 aa)
BABAM1BRISC and BRCA1 A complex member 1. (317 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
WDR48WD repeat domain 48. (684 aa)
FHFumarate hydratase. (510 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
DHX9DExH-box helicase 9. (1270 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
NFRKBNuclear factor related to kappaB binding protein. (1299 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1849 aa)
ACTL6AActin like 6A; Belongs to the actin family. (430 aa)
SPIDRScaffold protein involved in DNA repair. (915 aa)
BRD8Bromodomain containing 8. (1235 aa)
NPAS2Neuronal PAS domain protein 2. (827 aa)
YEATS4YEATS domain containing 4. (227 aa)
ENSPPAP00000018336Uncharacterized protein. (311 aa)
WASWASP actin nucleation promoting factor. (502 aa)
PIAS4Protein inhibitor of activated STAT 4. (573 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa)
EPC1Enhancer of polycomb homolog. (836 aa)
FANCBFA complementation group B. (858 aa)
ENSPPAP00000019066UBIQUITIN_CONJUGAT_2 domain-containing protein. (95 aa)
ENSPPAP00000019077Uncharacterized protein. (54 aa)
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa)
ENSPPAP00000019394HMG box domain-containing protein. (174 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ENSPPAP00000020965KH type-2 domain-containing protein. (250 aa)
SIRT6Sirtuin 6. (355 aa)
SPIRE1Spire type actin nucleation factor 1. (643 aa)
RAD51AP1RAD51 associated protein 1. (355 aa)
ACTL6BActin like 6B; Belongs to the actin family. (426 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1087 aa)
FAM178BFamily with sequence similarity 178 member B. (649 aa)
ENSPPAP00000016729Ribosomal_S3_C domain-containing protein. (100 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (570 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
CCDC117Coiled-coil domain containing 117. (279 aa)
SPIRE2Spire type actin nucleation factor 2. (665 aa)
SIRT1Sirtuin 1. (693 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (740 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (200 aa)
RBBP8RB binding protein 8, endonuclease. (895 aa)
CEBPGCCAAT enhancer binding protein gamma. (150 aa)
RIF1Replication timing regulatory factor 1. (2473 aa)
PBRM1Polybromo 1. (1690 aa)
ENSPPAP00000005256Uncharacterized protein. (83 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
ENSPPAP00000004806Uncharacterized protein. (142 aa)
ENSPPAP00000004466MPN domain-containing protein. (294 aa)
INO80DINO80 complex subunit D. (1027 aa)
ENSPPAP00000003540Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
MRGBP-2Uncharacterized protein. (146 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1491 aa)
HELQHelicase, POLQ like. (1101 aa)
SHLD1Shieldin complex subunit 1. (205 aa)
PHF10PHD finger protein 10. (469 aa)
TRIM28Tripartite motif containing 28. (736 aa)
ENSPPAP00000023917Uncharacterized protein. (311 aa)
ARID1AAT-rich interaction domain 1A. (2150 aa)
SMARCD2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (466 aa)
ENSPPAP00000024326Uncharacterized protein. (370 aa)
TIMELESSTimeless circadian regulator. (1208 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
UIMC1Ubiquitin interaction motif containing 1. (727 aa)
ENSPPAP00000025554Uncharacterized protein. (324 aa)
ENSPPAP00000026193Uncharacterized protein; Belongs to the actin family. (249 aa)
ENSPPAP00000027030DEP domain-containing protein. (1105 aa)
TRRAPTransformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3859 aa)
YY1Uncharacterized protein. (370 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (467 aa)
ZCWPW1Zinc finger CW-type and PWWP domain containing 1. (648 aa)
MRNIPMRN complex interacting protein. (343 aa)
BCL7BUncharacterized protein. (236 aa)
OOEPOocyte expressed protein. (149 aa)
DPF3Uncharacterized protein. (378 aa)
ACTBActin beta; Belongs to the actin family. (372 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (2005 aa)
VPS72Vacuolar protein sorting 72 homolog. (364 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (221 aa)
INO80BPAPA-1 domain-containing protein. (356 aa)
ENSPPAP00000031361Uncharacterized protein. (207 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
KMT5BLysine methyltransferase 5B. (885 aa)
BRD7Bromodomain containing 7. (644 aa)
BABAM2BRISC and BRCA1 A complex member 2. (415 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1566 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (430 aa)
MRGBPUncharacterized protein. (75 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSPPAP00000033446KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (253 aa)
SETMARSET domain and mariner transposase fusion gene. (684 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (317 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
EPC2Enhancer of polycomb homolog. (807 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1173 aa)
MCRS1Microspherule protein 1. (475 aa)
PARP3Poly [ADP-ribose] polymerase. (539 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
HDAC10Histone deacetylase 10. (669 aa)
EP400E1A binding protein p400. (2918 aa)
WRAP53WD repeat containing antisense to TP53. (533 aa)
TMEM161ATransmembrane protein 161A. (479 aa)
ENSPPAP00000038467FAM35_C domain-containing protein. (224 aa)
TFPTTCF3 fusion partner. (253 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
INO80INO80 complex ATPase subunit. (1556 aa)
ENSPPAP00000039065Uncharacterized protein. (350 aa)
MFSD11Major facilitator superfamily domain containing 11. (449 aa)
DPF1Double PHD fingers 1. (408 aa)
LOC100987671UBIQUITIN_CONJUGAT_2 domain-containing protein. (88 aa)
FAM168AFamily with sequence similarity 168 member A. (235 aa)
ENSPPAP00000040700UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
DPF2Double PHD fingers 2. (405 aa)
FOXM1Forkhead box M1. (763 aa)
HDGFL2HDGF like 2. (646 aa)
UBE2V2UBIQUITIN_CONJUGAT_2 domain-containing protein. (151 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (855 aa)
INO80EINO80 complex subunit E. (244 aa)
KMT5CLysine methyltransferase 5C. (390 aa)
ARID2AT-rich interaction domain 2. (1835 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
KHDC3LKH domain containing 3 like, subcortical maternal complex member. (217 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1030 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1058 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (238 aa)
MBTD1Mbt domain containing 1. (630 aa)
ENSPPAP00000009290Uncharacterized protein. (354 aa)
LOC100985819Uncharacterized protein. (377 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
MEAF6MYST/Esa1 associated factor 6. (179 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1245 aa)
ENSPPAP00000011209EP400_N domain-containing protein. (419 aa)
ING3Inhibitor of growth protein. (418 aa)
FUSFUS RNA binding protein. (523 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (368 aa)
ARID1BARID domain-containing protein. (1539 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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