STRINGSTRING
EGFR EGFR ATRX ATRX GLI1 GLI1 EREG EREG ENSPPAP00000039065 ENSPPAP00000039065 INO80 INO80 WIZ WIZ ENDOG ENDOG STOML2 STOML2 KAT7 KAT7 NRM NRM CTC1 CTC1 NPM2 NPM2 BRPF3 BRPF3 STN1 STN1 LPIN1 LPIN1 ENSPPAP00000019077 ENSPPAP00000019077 FAF1 FAF1 PCNA PCNA DBF4B DBF4B CDK2 CDK2 E2F8 E2F8 SSBP1 SSBP1 CDT1 CDT1 GLI2 GLI2 DNA2 DNA2 ENSPPAP00000031014 ENSPPAP00000031014 ATF1 ATF1 ENSPPAP00000031824 ENSPPAP00000031824 UCN UCN EGF EGF E2F7 E2F7 MAS1 MAS1 ENSPPAP00000003540 ENSPPAP00000003540 DBF4 DBF4 TNFAIP1 TNFAIP1 CDC7 CDC7 KCTD13 KCTD13 MAP2K4 MAP2K4 SMARCA5 SMARCA5 BCAR3 BCAR3 DHX9 DHX9 CDK1 CDK1 ENSPPAP00000014328 ENSPPAP00000014328 ATAD5 ATAD5 CIZ1 CIZ1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGFRReceptor protein-tyrosine kinase. (1201 aa)
ATRXATRX chromatin remodeler. (2492 aa)
GLI1GLI family zinc finger 1. (1106 aa)
EREGEpiregulin. (169 aa)
ENSPPAP00000039065Uncharacterized protein. (350 aa)
INO80INO80 complex ATPase subunit. (1556 aa)
WIZWIZ zinc finger. (954 aa)
ENDOGEndonuclease. (188 aa)
STOML2Stomatin like 2. (361 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
NRMNurim. (262 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
NPM2Nucleophosmin/nucleoplasmin 2. (213 aa)
BRPF3Bromodomain and PHD finger containing 3. (1204 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
LPIN1Lipin 1. (929 aa)
ENSPPAP00000019077Uncharacterized protein. (54 aa)
FAF1Fas associated factor 1. (649 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
DBF4BDBF4 zinc finger B. (615 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
E2F8E2F transcription factor 8. (867 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
CDT1Chromatin licensing and DNA replication factor 1. (470 aa)
GLI2GLI family zinc finger 2. (1587 aa)
DNA2DNA replication helicase/nuclease 2. (1060 aa)
ENSPPAP00000031014Protein kinase domain-containing protein. (371 aa)
ATF1Activating transcription factor 1. (270 aa)
ENSPPAP00000031824Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (341 aa)
UCNUrocortin. (124 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
E2F7E2F transcription factor 7. (911 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
ENSPPAP00000003540Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (246 aa)
DBF4DBF4 zinc finger. (655 aa)
TNFAIP1TNF alpha induced protein 1. (316 aa)
CDC7Cell division cycle 7. (574 aa)
KCTD13Uncharacterized protein. (272 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (826 aa)
DHX9DExH-box helicase 9. (1270 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ENSPPAP00000014328BRCT domain-containing protein. (581 aa)
ATAD5ATPase family AAA domain containing 5. (1832 aa)
CIZ1CDKN1A interacting zinc finger protein 1. (947 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.