STRINGSTRING
NFE2L2 NFE2L2 ITGB8 ITGB8 SERPINE1 SERPINE1 FGF18 FGF18 PDCD6 PDCD6 LOC100989599 LOC100989599 TGFBR2 TGFBR2 BTG1 BTG1 SEMA5A SEMA5A VEGFC VEGFC HIPK2 HIPK2 RAPGEF3 RAPGEF3 KDR KDR CXCR3 CXCR3 PTGIS PTGIS CCL11 CCL11 FGF2 FGF2 VEGFD VEGFD CMA1 CMA1 ITGA5 ITGA5 PKM PKM ITGAX ITGAX ZC3H12A ZC3H12A CTSH CTSH JUP JUP FGF1 FGF1 STAT3 STAT3 TJP1 TJP1 IL1B IL1B APELA APELA PDCL3 PDCL3 TNN TNN CD40 CD40 S100A1 S100A1 HSPB6 HSPB6 GAB1 GAB1 RTN4 RTN4 NOS3 NOS3 NR2E1 NR2E1 ENSPPAP00000032115 ENSPPAP00000032115 STIM1 STIM1 CD34 CD34 ITGB1 ITGB1 VEGFB VEGFB ENSPPAP00000031546 ENSPPAP00000031546 HK2 HK2 SLC39A12 SLC39A12 PTK2B PTK2B RAMP2 RAMP2 BMPER BMPER AGO2 AGO2 SMOC2 SMOC2 ADM2 ADM2 HSPB1 HSPB1 HPSE HPSE ENSPPAP00000028879 ENSPPAP00000028879 TNFSF12 TNFSF12 PRKD2 PRKD2 PAK4 PAK4 DLL1 DLL1 PRKD1 PRKD1 ENSPPAP00000027667 ENSPPAP00000027667 TIE1 TIE1 HIPK1 HIPK1 CELA1 CELA1 ABL1 ABL1 NINJ1 NINJ1 HMOX1 HMOX1 C3 C3 AGGF1 AGGF1 CDH5 CDH5 PIK3CD PIK3CD AKT3 AKT3 ACVRL1 ACVRL1 HGF HGF ANGPTL4 ANGPTL4 MYDGF MYDGF NTRK1 NTRK1 PRKCB PRKCB SIRT6 SIRT6 TEK TEK EPHA1 EPHA1 ISL1 ISL1 AQP1 AQP1 ITGB2 ITGB2 RRAS RRAS ANXA3 ANXA3 CHI3L1 CHI3L1 GRN GRN TMIGD2 TMIGD2 FLT1 FLT1 VASH2 VASH2 F3 F3 TBXA2R TBXA2R C5 C5 WARS2 WARS2 NODAL NODAL IL1A IL1A DDAH1 DDAH1 PLCG1 PLCG1 ANGPT2 ANGPT2 SP1 SP1 PRKCA PRKCA ECM1 ECM1 TLR3 TLR3 CCBE1 CCBE1 ENG ENG PGF PGF BRCA1 BRCA1 ENSPPAP00000015671 ENSPPAP00000015671 ANGPTL3 ANGPTL3 ITGB3 ITGB3 ENSPPAP00000014225 ENSPPAP00000014225 JMJD8 JMJD8 ERAP1 ERAP1 CXCL8 CXCL8 SASH1 SASH1 GHSR GHSR TERT TERT ZNF304 ZNF304 MTDH MTDH LRG1 LRG1 ENSPPAP00000011278 ENSPPAP00000011278 HIF1A HIF1A ADAM12 ADAM12 CCL24 CCL24 JCAD JCAD CYBB CYBB ENSPPAP00000010225 ENSPPAP00000010225 ENSPPAP00000010058 ENSPPAP00000010058 XBP1 XBP1 EMILIN1 EMILIN1 ANGPT4 ANGPT4 GATA2 GATA2 SMAD1 SMAD1 C5AR1 C5AR1 WNT5A WNT5A ETS1 ETS1 VEGFA VEGFA GHRL GHRL EMILIN2 EMILIN2 SIRT1 SIRT1 CHRNA7 CHRNA7 CCR3 CCR3 RLN2 RLN2 EMP2 EMP2 SPHK1 SPHK1 MDK MDK RHOB RHOB C3AR1 C3AR1 THBS1 THBS1 JAK1 JAK1 KLF4 KLF4 GATA6 GATA6 EMC10 EMC10 GDF2 GDF2 CYSLTR1 CYSLTR1 IL10 IL10 APLNR APLNR RUNX1 RUNX1 GATA4 GATA4 ADM ADM NRP1 NRP1 FUT1 FUT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (757 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (324 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
PDCD6Uncharacterized protein. (121 aa)
LOC100989599Uncharacterized protein; Belongs to the cytochrome P450 family. (339 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
BTG1BTG anti-proliferation factor 1. (170 aa)
SEMA5ASemaphorin 5A. (1074 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
HIPK2Protein kinase domain-containing protein. (954 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (905 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (501 aa)
CCL11C-C motif chemokine. (97 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (260 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
CMA1Chymase 1; Belongs to the peptidase S1 family. (252 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1046 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1169 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
JUPJunction plakoglobin. (745 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1772 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
PDCL3Phosducin like 3. (239 aa)
TNNTenascin N. (1299 aa)
CD40CD40 molecule. (277 aa)
S100A1Protein S100; Belongs to the S-100 family. (147 aa)
HSPB6Heat shock protein family B (small) member 6. (140 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
RTN4Reticulon. (604 aa)
NOS3Nitric oxide synthase 3. (997 aa)
NR2E1Uncharacterized protein. (385 aa)
ENSPPAP00000032115Uncharacterized protein. (883 aa)
STIM1Stromal interaction molecule 1. (791 aa)
CD34CD34 molecule. (328 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (186 aa)
ENSPPAP00000031546Phosducin domain-containing protein. (220 aa)
HK2Hexokinase 2. (917 aa)
SLC39A12Solute carrier family 39 member 12. (691 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
RAMP2Receptor activity modifying protein 2. (175 aa)
BMPERBMP binding endothelial regulator. (685 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (873 aa)
SMOC2SPARC related modular calcium binding 2. (449 aa)
ADM2Adrenomedullin 2. (148 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
HPSEHeparanase. (543 aa)
ENSPPAP00000028879Pyruvate kinase; Belongs to the pyruvate kinase family. (457 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (236 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (826 aa)
PAK4P21 (RAC1) activated kinase 4. (590 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (624 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
ENSPPAP00000027667Uncharacterized protein. (98 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
HIPK1Homeodomain interacting protein kinase 1. (1210 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (258 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
NINJ1Ninjurin 1. (141 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
C3Complement C3. (1614 aa)
AGGF1Uncharacterized protein. (714 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (812 aa)
ANGPTL4Angiopoietin like 4. (406 aa)
MYDGFMyeloid derived growth factor. (173 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
SIRT6Sirtuin 6. (355 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
EPHA1EPH receptor A1. (965 aa)
ISL1ISL LIM homeobox 1. (349 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
ITGB2Integrin beta. (806 aa)
RRASRAS related. (176 aa)
ANXA3Annexin. (323 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (389 aa)
GRNGranulin precursor. (593 aa)
TMIGD2Transmembrane and immunoglobulin domain containing 2. (282 aa)
FLT1Uncharacterized protein. (736 aa)
VASH2Vasohibin 2. (290 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (389 aa)
C5Complement C5. (1676 aa)
WARS2Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (360 aa)
NODALNodal growth differentiation factor. (347 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
DDAH1Uncharacterized protein. (182 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1248 aa)
ANGPT2Angiopoietin 2. (495 aa)
SP1Sp1 transcription factor. (786 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
ECM1Extracellular matrix protein 1. (540 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
ENGEndoglin. (658 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (221 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1849 aa)
ENSPPAP00000015671Protein kinase domain-containing protein. (414 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (814 aa)
ENSPPAP00000014225Protein kinase domain-containing protein. (433 aa)
JMJD8Jumonji domain containing 8. (270 aa)
ERAP1Aminopeptidase. (941 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
SASH1SAM and SH3 domain containing 1. (1251 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1040 aa)
ZNF304Zinc finger protein 304. (705 aa)
MTDHMetadherin. (567 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
ENSPPAP00000011278Protein kinase domain-containing protein. (351 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
ADAM12ADAM metallopeptidase domain 12. (874 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
JCADJunctional cadherin 5 associated. (1352 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
ENSPPAP00000010225Pyruvate kinase; Belongs to the pyruvate kinase family. (504 aa)
ENSPPAP00000010058Uncharacterized protein. (165 aa)
XBP1BZIP domain-containing protein. (380 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
ANGPT4Angiopoietin 4. (503 aa)
GATA2GATA binding protein 2. (480 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (372 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
EMILIN2Elastin microfibril interfacer 2. (1021 aa)
SIRT1Sirtuin 1. (693 aa)
CHRNA7Uncharacterized protein. (511 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
RLN2Relaxin 2. (185 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
SPHK1Sphingosine kinase 1. (470 aa)
MDKMidkine. (143 aa)
RHOBRas homolog family member B. (196 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (482 aa)
THBS1Thrombospondin 1. (1173 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
KLF4Kruppel like factor 4. (477 aa)
GATA6Uncharacterized protein. (402 aa)
EMC10Uncharacterized protein. (378 aa)
GDF2Growth differentiation factor 2. (429 aa)
CYSLTR1Cysteinyl leukotriene receptor 1. (337 aa)
IL10Interleukin 10. (178 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
GATA4GATA binding protein 4. (396 aa)
ADMAdrenomedullin. (185 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (366 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.